Anesthesia in Parathyroidectomy for Secondary Hyperparathyroidism of Chronic Kidney Disease by ZHANG Yangyang, ZHU Bo

“…The perioperative management of such operations requires comprehensive consideration of the influence of primary disease, secondary pathophysiological changes and surgical factors, which poses a challenge to anesthesiologists. …”
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Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option by Benedikt Zujalovic, Eberhard Barth

“…It might be causal for multiple organ deterioration if it is based on cholinergic deficiency and has to be treated at his pathophysiological roots whenever possible.…”
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Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective by Jia-Jun Ju, Li-Hua Hang, Li-Hua Hang

“…Previously clinical treatments for ICH have largely been based on a single pathophysiological perspective, and there remains a lack of curative interventions. …”
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Co-existing ulcerative colitis and takayasu arteritis: A case-based review by Karan Rajgopal Kalani, Anuj Achyut Ban, Sumeet Singla

“…Both Takayasu arteritis (TAK) and ulcerative colitis (UC) are uncommon diseases with diverse pathophysiological and clinical features. Their occurrence in the same patient is highly unusual and interesting. …”
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Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…Hyperglycemia results in inhibition of cleavage of integrin-associated protein (IAP) thereby allowing it to bind to SHPS-1 which results in pathophysiologic changes in endothelial function. This study determined if an anti-rat IAP antibody directed against the SHPS-1 binding site which disrupts IAP/SHPS-1 association could inhibit these pathophysiologic changes. …”
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Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review by Fang Jia, Shun-Yi Shi, Si-Fan Fei, Min Zhou, Jian-Jun Li

“…Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. …”
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Hypertrophic Obstructive Cardiomyopathy Masked by Tako-Tsubo Syndrome: A Case Report by Y. Daralammori, M. El Garhy, M. R. Gayed, A. Farah, B. Lauer, M. A. Secknus

“…Left ventricular outflow obstruction might be part of the pathophysiological mechanism of Tako-tsubo cardiomyopathy. …”
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Choosing an Animal Model for the Study of Functional Dyspepsia by Yang Ye, Xue-Rui Wang, Yang Zheng, Jing-Wen Yang, Na-Na Yang, Guang-Xia Shi, Cun-Zhi Liu

“…Emerging evidence is beginning to unravel the pathophysiologies of FD, and new data on treatment are helping to guide evidence-based practice. …”
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Elevated CA-125 as Humoral Biomarker of Congestive Heart Failure: Illustrative Cases and a Short Review of Literature by Attila Frigy, Boglárka Belényi, Ádám Kirchmaier, Nándor Fekete, István Adorján Szabó

“…The paper presents a short review of the main biochemical, pathophysiological, and clinical data linked to CA-125, with special accent on its utility in patients with HF.…”
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Experimental methods of portal hypertension studying by D. V. Garbuzenko

“…To study complex pathophysiological disorders, innate to portal hypertension, various pilot models providing complex evaluation and development of adequate treatment methods are used. …”
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Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis by Nesreen Jaafar, Maria Khoueiry, Samia J. Khoury, Achraf Makki

“…If these two diseases are interconnected, in their pathophysiological mechanism remains a hypothesis that will need further investigation.…”
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MicroRNAs in Neurotoxicity by Prameet Kaur, Arunmozhiarasi Armugam, Kandiah Jeyaseelan

“…In this paper, we discuss some of the neuronal pathophysiological conditions that could be caused by dysregulated microRNAs.…”
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Stimulators and Activators of Soluble Guanylate Cyclase: Review and Potential Therapeutic Indications by Bobby Nossaman, Edward Pankey, Philip Kadowitz

“…Two classes of compounds have been developed that can directly activate sGC and increase cGMP formation in pathophysiologic conditions when NO formation and bioavailability are impaired or when NO tolerance has developed. …”
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Current Treatment of Heart Failure with Preserved Ejection Fraction: Should We Add Life to the Remaining Years or Add Years to the Remaining Life? by Jia Li, Peter Moritz Becher, Stefan Blankenberg, Dirk Westermann

“…In this review, we will focus on the tested as well as the promising therapeutic options that are currently studied in patients with heart failure with preserved ejection fraction, along with a brief discussion of pathophysiological mechanisms and diagnostic options that are helpful to increase our understanding of novel therapeutic strategies.…”
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Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments by Yu Xueting, He Huimei, Wen Jie, Xu Xiuyuan, Ruan Zhaojuan, Hu Rui, Wang Fang, Ju Haibing

“…This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, and future research directions of cognitive impairment in diabetes.…”
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CRISPR in 3D: Innovations in Disease Modelling and Personalized Medicine by Louis J Gautier

“…CRISPR integration with 3D culture systems such as organ-on-a-chips, as well as fast emerging commercial technologies, has encouraged translation of more complex pathophysiological modelling and personalized medicine.…”
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Exploring the Research Focus of RNA-Binding Proteins in Trauma and Burns by Sujie Xie, Yifan Liu, Wei Zhang, Jianyu Lu, Xirui Tong, Jie Huang, Yushu Zhu, Minjuan Wu, Xinya Guo, Hanlin Sun, Minyi Gu, Luofeng Jiang, Shuyuan Xian, Runzhi Huang, Zhaofan Xia, Shizhao Ji

“…Notably, we identified two primary hotspots: RBPs in the pathophysiological mechanisms of various traumatic injuries and RBPs in the processes of cutaneous wound healing. …”
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BlockingαVβ3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats by Laura A. Maile, Katherine Gollahon, Christine Wai, Paul Dunbar, Walker Busby, David Clemmons

“…This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). …”
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Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future by Marc Pauper, Andreas Hentschel, Malte Tiburcy, Sergi Beltran, Tobias Ruck, Ulrike Schara-Schmidt, Andreas Roos

“…Hence, proteomics is an excellent large-scale analytical tool for the diagnostic workup of (hereditary) muscle diseases and warrants systematic profiling of underlying pathophysiological processes. The steady development may allow to overcome existing limitations including a quenched dynamic range and quantification of different protein isoforms. …”
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Developmental Origins of Chronic Renal Disease: An Integrative Hypothesis by F. Boubred, M. Saint-Faust, C. Buffat, I. Ligi, I. Grandvuillemin, U. Simeoni

“…Reduced nephron number constitutes a “factor of vulnerability” when additional factors, in particular a rapid postnatal growth or overfeeding, promote the early onset of diseases through a complex combination of various pathophysiological pathways.…”
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