Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

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From cellular senescence towards age-related macular degeneration: the role of telomeres by L.K. Moshetova, O.I. Abramova, K.I. Turkina, O.P. Dmitrenko, N.S. Karpova

“…Karpova²</b> </p> <p> <b>¹Russian Medical Academy of Continuous Professional Education, Moscow, <br> &nbsp;Russian Federation</b> </p> <p> <b>²Institute of General Pathology and Pathophysiology, Moscow, Russian Federatio</b>s&nbsp; </p> <p> <i>Since the discovery, telomeres and telomerase have been extensively studied, at first, as a mechanism of cellular senescence, and then, as human health and disease indicators. …”
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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…The observed histological findings may contribute to our understanding of SBC pathophysiology in the context of cartilage repair procedures. …”
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High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones by Gayane Manukyan, Tomas Papajik, Zuzana Mikulkova, Renata Urbanova, Veronika Smotkova Kraiczova, Jakub Savara, Milos Kudelka, Peter Turcsanyi, Eva Kriegova

“…Contribution of CXCR3 to CLL pathophysiology and its suitability for prognostication and therapeutic exploitation deserves future investigations.…”
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Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats by Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Kohei Yuyama, Hideki Nakamura, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto

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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

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Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism by Naika Prince, Lucia N. Peralta Marzal, Léa Roussin, Magali Monnoye, Catherine Philippe, Elise Maximin, Sabbir Ahmed, Karoliina Salenius, Jake Lin, Reija Autio, Youri Adolfs, R. Jeroen Pasterkamp, Johan Garssen, Laurent Naudon, Sylvie Rabot, Aletta D. Kraneveld, Paula Perez-Pardo

“…Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. …”
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Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease... by A. A. Makarova, P. M. Melnikova, A. D. Rogachev, P. S. Demenkov, T. V. Ivanisenko, E. V. Predtechenskaya, S. Y. Karmanov, V. V. Koval, A. G. Pokrovsky, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko

“…To comprehensively analyze the pathophysiology of PD and VP, the methods of systems biology and gene network reconstruction are essential. …”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

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evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

“…Abstract Background Disease-modifying therapies targeting the diverse pathophysiology of Alzheimer’s disease (AD), including neuroinflammation, represent potentially important and novel approaches. …”
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Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism by Lucia Ciccoli, Claudio De Felice, Eugenio Paccagnini, Silvia Leoncini, Alessandra Pecorelli, Cinzia Signorini, Giuseppe Belmonte, Roberto Guerranti, Alessio Cortelazzo, Mariangela Gentile, Gloria Zollo, Thierry Durand, Giuseppe Valacchi, Marcello Rossi, Joussef Hayek

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Identification of macrophage polarisation and mitochondria-related biomarkers in diabetic retinopathy by Weifeng Liu, Bin Tong, Jian Xiong, Yanfang Zhu, Hongwei Lu, Haonan Xu, Xi Yang, Feifei Wang, Peng Yu, Yunwei Hu

“…Therefore, the common mechanism of mitochondrial related genes (MRGs) and macrophage polarisation related genes (MPRGs) in DR is explored in our study to illustrate the pathophysiology of DR. Methods In this study, using common transcriptome data, differentially expressed genes (DEGs) were firstly analysed for GSE221521, while module genes related to MPRGs were obtained by weighted gene co-expression network analysis (WGCNA), intersections of DEGs with MRGs were taken, intersections of DEGs with module genes of the MPRGs were taken. …”
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Integration of metabolomics methodologies for the development of predictive models for mortality risk in elderly patients with severe COVID-19 by Shanpeng Cui, Qiuyuan Han, Ran Zhang, Siyao Zeng, Ying Shao, Yue Li, Ming Li, Wenhua Liu, Junbo Zheng, Hongliang Wang

“…Our study addresses the critical gap in current research by utilizing current patient samples, providing fresh insights into the pathophysiology of the disease in a partially immunized global population. …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…Li Li,1– 3,&ast; Zeyu He,3– 5,&ast; Chengqian Yu,3– 5 Chao Zhang,3– 5 Yanqiu Yu,6 Yuanhong Li,3– 5 Xuegang Xu3– 5 1ShanXi Medical University, Taiyuan, People’s Republic of China; 2Department of Dermatology, The First Hospital of ShanXi Medical University, Taiyuan, 030001, People’s Republic of China; 3Department of Dermatology, The First Hospital of China Medical University, Shenyang, 030001, People’s Republic of China; 4Key Laboratory of Immunodermatology (China Medical University), Ministry of Education, Shenyang, 110001, People’s Republic of China; 5NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, 110001, People’s Republic of China; 6Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuegang Xu, Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, 110001, People’s Republic of China, Email xuxuegang2749290@163.com Li Li, Department of Dermatology, The First Hospital of ShanXi Medical University, No. 85 South Jiefang Road, Yingze District, Taiyuan, Shanxi Province, 030001, People’s Republic of China, Email lilizaimu0807@163.comBackground: Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.Objective: This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.Methods & Materials: In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. …”
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The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs) by Patrizia Cancemi, Anna Aiello, Giulia Accardi, Rosalia Caldarella, Giuseppina Candore, Calogero Caruso, Marcello Ciaccio, Laura Cristaldi, Francesca Di Gaudio, Valentina Siino, Sonya Vasto

“…Thus, in order to gain insight into the pathophysiology of ageing and to identify new markers of longevity, we analysed the activity levels of MMP-2 and MMP-9 in association with some relevant haematochemical parameters in a Sicilian population, including long-living individuals (LLIs, ≥95 years old). …”
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Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

“…As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. …”
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TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis by Joel J. Toledo Mauriño, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Rafael Barreto-Zuñiga, Braulio Martínez Benítez, Julio Granados, Jesus K. Yamamoto-Furusho

“…The TRPV subfamily clearly showed a differential expression in the UC patients compared with the controls, suggesting their role in the pathophysiology of UC.…”
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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

“…These potentially noninvasive biomarkers may facilitate understanding of FCGS pathophysiology and guide future therapeutic research.…”
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Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury by Liujun Tao, Jie Xu, Liangyan Jiang, Juntao Hu, Zhanhong Tang

“…Emerging evidence suggests a novel role for ferroptosis in the pathophysiology of ALI, though the precise mechanisms remain unclear. …”
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Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011–2018 by Yaping Deng, Yingting Luo, Yilei Shen, Yong Zhao, Wei Cao, Jie Cao, Lijuan Xu, Lin Kong

“…Furthermore, FMI was identified as a more potent mediator of the hypovitaminosis D-IR relationship compared to BMI, highlighting its importance in the pathophysiology of insulin resistance in adolescents.…”
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