Assessment of long-term changes in subvalvular aortic stenosis in patients following transcatheter aortic valve implantation by Vladlen V. Bazylev, Andrey B. Voevodin, Alexey S. Masyutin

“…BACKGROUND: The clinical course, pathophysiology, and therapeutic options for valvular and subvalvular (accompanied by hypertrophic cardiomyopathy, HCM) aortic stenosis are well known separately, but the rare combination of severe aortic stenosis (AS) and obstructive HCM presents great diagnostic and treatment challenges. …”
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Defining New Research Questions and Protocols in the Field of Traumatic Brain Injury through Public Engagement: Preliminary Results and Review of the Literature by Shumaila Hasan, Aswin Chari, Mario Ganau, Chris Uff

“…At present, we still lack a full understanding on the pathophysiology of TBI, and biomarkers represent the next frontier of breakthrough discoveries. …”
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Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies by Lorenzo Drago, Lorenzo Drago, Luigi Regenburgh De La Motte, Loredana Deflorio, Delia Francesca Sansico, Michela Salvatici, Emanuele Micaglio, Manuele Biazzo, Fabiana Giarritiello, Fabiana Giarritiello

“…In vitro, in vivo and in silico analyses were excluded to ensure a strong translational focus on human pathophysiology. Notably, miRNAs, stable and abundant in patients, are emerging as promising biomarkers of microbiome-driven inflammation. …”
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Inhibition of Tannerpin-M encoded by periodontal pathogens on serine proteases released by granulocytes by PAN Zihao, XU Jiawei, ZHOU Aiwu

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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…This review summarizes the pathophysiology underlying the proliferation of myeloid cells that occurs with incipient neoplasia and explores the role of innate immune-host interactions, specifically granulocytes and neutrophil extracellular traps, in promoting hepatic colonization by tumor cells through the formation of the “premetastatic niche”. …”
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CalciumZero: a toolbox for fluorescence calcium imaging on iPSC derived brain organoids by Xiaofu He, Yian Wang, Yutong Gao, Xuchen Wang, Zhixiong Sun, Huixiang Zhu, Kam W. Leong, Bin Xu

“…Investigating the dynamics of the calcium level in neurons is essential not just for understanding the pathophysiology of neuropsychiatric disorders but also as a quantitative gauge to evaluate the influence of drugs on neuron activities. …”
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Fourier Transform Infrared Spectroscopy Analysis as a Tool to Address Aβ Impact on Extracellular Vesicles by Margarida Vaz, Tânia Soares Martins, Kevin Leandro, Luís Pereira de Almeida, Odete A. B. da Cruz e Silva, Alexandra Nunes, Ana Gabriela Henriques

“…Despite advances, further understanding of Alzheimer’s disease pathophysiology is needed, particularly the role of Aβ neurotoxic peptide. …”
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Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 by Nathane Braga da Silva Rezende, Fernanda Gomes de Queiroz Barros-Aragão, Talita Pinto, Viviane Tavares Carvalho Crelier, Marcos Ravi Figueiredo, Carlos Otávio Brandão, Andrea Silveira de Souza, Fernanda Tovar-Moll, Gabriel R. de Freitas

“…Conclusion Encephalitis associated with severe acute respiratory syndrome coronavirus 2 infection is rare but responsible for chronic sequelae in cognitive and motor aspects. The pathophysiology seems to be associated with both the immune-mediated and inflammatory processes, and the low frequency of paraclinical findings demands a high clinical suspicion.…”
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Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/− mice by Colette Reinhold, Susanne Knorr, Rhonda L. McFleder, Lisa Harder-Rauschenberger, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip

“…The disease is caused by mutations in the THAP1 gene, although the precise mechanisms by which these mutations contribute to the pathophysiology of dystonia remain unclear. The incomplete penetrance of DYT-THAP1 dystonia, estimated at 40 to 60 %, suggests that an environmental trigger may be required for the manifestation of the disease in genetically predisposed individuals. …”
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Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia by Laure Ponthier, Chahrazed El Hamel, Perrine Coste Mazeau, Sophie Martinez, Sarah Wehbe, Rachel Froget, Catherine Yardin, Vincent Guigonis

“…Abstract Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been specifically explored. …”
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Unraveling ankylosing spondylitis: Exploring the genetic and immunological factors and latest treatment innovations by Nilasree Hazra, Sudeshna Sengupta, Dipannita Burman, Jyoti Sekhar Banerjee, Malavika Bhattacharya

“…Gut microbiota significantly affects ankylosing spondylitis (AS) pathophysiology. Environmental factors, like smoking, and genetic predispositions can worsen AS. …”
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Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia by Vijay Murali Ravi Mythili, Ramya Lakshmi Rajendran, Raksa Arun, Vasanth Kanth Thasma Loganathbabu, Danyal Reyaz, ArulJothi Kandasamy Nagarajan, Byeong-Cheol Ahn, Prakash Gangadaran

“…Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of CLI, necessitating the identification of alternative methodologies. …”
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Haploidentical stem cell transplantation with posttransplant cyclophosphamide in children with Wiskott–Aldrich syndrome: a case report by Le Nguyen Ngoc Quynh, Binh Nguyen Thanh, Lien Luong Thi, Thuy Nguyen Thi Dieu, Duong Dang Anh, Pamela P. Lee, Tung Cao Viet, Dien Tran Minh

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Genetic variability in the cholecystokinin A receptor affects lipid profile and glucose tolerance in patients with polycystic ovary syndrome by Eva Drnovsek, Mojca Jensterle, Katja Goričar, Sara Redenšek, Andrej Janež, Irina Milisav, Vita Dolžan

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Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia by Shymaa E. Ayoub, Azza M. Ahmed, Mostafa Y. Abdelwahed, Abeer A. Khalefa, Aeshah A. Awaji, Samer S. Zekry, Enas G. Ibrahim, Hana M. Eid, Shimaa M. Elasmer, Reham Fares

“…Abstract About 5% of the population suffers from fibromyalgia (FM), a chronic multi-symptom pain illness whose pathophysiology is still unknown. We aimed to be the first to investigate the possible association of sera levels of miR-217 and miR-532 in patients with fibromyalgia and correlate their expression levels to different clinical and biochemical disease criteria. …”
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Improving general practitioners’ approaches to functional somatic syndromes: a pilot training program with a focus on compassion and communication by Gonthier Ariane, Linder Audrey, Sommer Johanna, Despland Jean-Nicolas, Ambresin Gilles

“…The educational framework of the training session is multimodal and includes theory on the pathophysiology of functional somatic syndromes, communication skills, and introspective learning including an introduction to compassion meditation. 20 physicians attended the pilot training session. 10 of them participated in the qualitative study. …”
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Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma by O. V. Saik, N. A. Konovalova, P. S. Demenkov, N. V. Ivanisenko, T. V. Ivanisenko, D. E. Ivanoshchuk, O. S. Konovalova, O. A. Podkolodnaya, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko

“…However, the molecular- genetic mechanisms underlying the pathophysiology of POAG are still poorly understood. Reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, transport, etc., requires the use of methods of automated knowledge extraction from texts of scientific publications. …”
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Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia by Mian Li, Yue Wu, Yan Xu, Xin Huang, Kerun Gao, Nannan Hu, Shuangyue Zhu, Chengpeng Wang, Sugai Liang

“…This shift towards increased neurotoxic product generation suggests that the dysregulation of the TRP-KYN pathway could play a role in the pathophysiology of schizophrenia.…”
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Fibromyalgia Detection and Diagnosis: A Systematic Review of Data-Driven Approaches and Clinical Implications by Anirudh Atmakuru, Subrata Chakraborty, Massimo Salvi, Oliver Faust, Prabal Datta Barua, Makiko Kobayashi, Ru San Tan, Filippo Molinari, Abdul Hafeez-Baig, U. Rajendra Acharya

“…In this systematic review, we explore the role of artificial intelligence in understanding FMS pathophysiology, discuss the present limitations, and shed light on future research avenues, aiming to translate findings into improved clinical outcomes.…”
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Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease by Caroline Ran, Karin Wirdefeldt, Lovisa Brodin, Mehrafarin Ramezani, Marie Westerlund, Fengqing Xiang, Anna Anvret, Thomas Willows, Olof Sydow, Anders Johansson, Dagmar Galter, Per Svenningsson, Andrea Carmine Belin

“…More detailed studies on NRF2 are needed in order to elucidate how this gene affects pathophysiology of Parkinson’s disease.…”
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