Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation by Zhuocheng Li, Lei Zhang, Zhichao Zhao

“…Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. …”
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Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study by O. Malkesman, T. Asaf, L. Shbiro, A. Goldstein, R. Maayan, A. Weizman, N. Kinor, E. Okun, B. Sredni, G. Yadid, A. Weller

“…The results imply that DHEA(S) and BDNF may be involved in the pathophysiology and pharmacotherapy of childhood depression.…”
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Short-term impact of glycaemic control and intravitreal ranibizumab treatment on serum cytokine levels and diabetic macular edema in patients with unregulated blood glucose by Hürkan Kerimoğlu, İbrahim Kılınc, Bülent Savut, Mustafa Kulaksızoğlu, Günhal Şatırtav, Gülfidan Bitirgen, Emine Tınkır Kayıtmazbatır

“…The therapeutic effect of intravitreal treatment on DME supports the role of the local cytokine milieu in the pathophysiology.…”
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Sex differences in the relationship between maternal and foetal glucocorticoids in a free-ranging large mammal by Amin, Bawan, Fishman, Ruth, Quinn, Matthew, Matas, Devorah, Palme, Rupert, Koren, Lee, Ciuti, Simone

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NF-κB-94ins/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia by Jie Yu, Mingqiang Hua, Xueyun Zhao, Rui Wang, Chaoqing Zhong, Chen Zhang, Ruiqing Wang, Guosheng Li, Na He, Ming Hou, Daoxin Ma

“…However, the role of the NLRP3 inflammasome in the pathophysiology of immune thrombocytopenia (ITP) remains unclear. …”
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Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis by Carola Cavallo, Giulia Merli, Nicoletta Zini, Stefania D’Adamo, Luca Cattini, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Rosa Maria Borzì, Giuseppe Filardo

“…In the perspective of developing a cell-free advanced therapy medicinal product, a focus has been recently addressed to the ADSC secretome that lends itself to an allogeneic use and can be further dissected for the selective purification of small extracellular vesicles (sEVs). sEVs can act as “biological drug carriers” to transfer information that mirror the pathophysiology of the providing cells. This is important in the clinical perspective where many OA patients are also affected by the metabolic syndrome (MetS). …”
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Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia by Vincenzo Di Stefano, Salvatore Iacono, Andrea Gagliardo, Bruna Maggio, Giuliana Guggino, Massimo Gangitano, Roberto Monastero, Vito Renato Maggio, Nadia Bolognini, Filippo Brighina

“…Results from this study confirm that patients with FM have a VCH suggesting that the pathological changes in cortical excitability might have important roles in the pathophysiology of FM. SIFI represents a noninvasive behavioral tool for the exploration of cross-sensory functional interplay.…”
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Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability by Alicia B. Feichtenbiner, Karinn Sytsma, Ryan P. O’Boyle, Rhonda Mittenzwei, Heather Maioli, Kathryn P. Scherpelz, Daniel D. Child, Ning Li, Jeanelle Ariza Torres, Lisa Keene, Amanda Kirkland, Kimberly Howard, Caitlin Latimer, C. Dirk Keene, Christopher Ransom, Amber L. Nolan

“…However, little is known regarding the pathophysiology of human traumatic brain injury, especially in the window after acute injury and the later life development of progressive neurodegenerative disease. …”
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Promising LOX proteins for cartilage-targeting osteoarthritis therapy by Luca Morici, Eric Allémann, Olivier Jordan, Ines Nikolić

“…Lectin-like oxidized low-density lipoprotein family are receptors located at the surface of chondrocytes, which interact with their ligand, ox-LDL, activating several catabolic pathways involved in OA pathophysiology. Finally, lysyl oxidase and lysyl oxidase-like are enzymes expressed intracellularly (in chondrocytes' cytoplasm) involved in elastin biosynthesis and collagen cross-linking in cartilage extracellular matrix. …”
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First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients by Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

“… Gaining knowledge about the differences in substance P (SP) and neurokinin 1 receptor (NK1R) levels between cardiac and hypertensive patients may help clarify how these neuropeptides could be involved in the pathophysiology of cardiovascular disorders. This study aimed to investigate the levels of SP and NK1R in individuals diagnosed with hypertension and cardiac conditions. …”
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Acute management of massive pulmonary embolism in pregnancy by Shahin Qadri, Shahin Qadri, Ashwini Bilagi, Ashwini Bilagi, Abha Sinha, Derek Connolly, Derek Connolly, Derek Connolly, Richard Murrin, Shagaf Bakour, Shagaf Bakour, Shagaf Bakour

“…During the post-partum period, thrombectomy is the treatment of choice.Learning objectives•To understand the pathophysiology of massive PE.•To appreciate the treatment options in pregnancy and postpartum period and their pros and cons.…”
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Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study by FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao

“…These findings offer novel insights into the pathophysiology of BPH and identify potential biomarkers and therapeutic targets for its diagnosis and management.…”
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Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Despite decades of research, full pathophysiology, a diagnostic roadmap, and clinical management strategies for endometriosis are not yet fully elucidated. …”
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Memahami Patofisiologi dan Aspek Klinis Syok Hipovolemik: Update dan Penyegar by Hardisman Hardisman

“…<br />Keywords: shock, hypovolemic and pathophysiology</p>…”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…The evaluation of biological markers will also help in understanding the pathophysiology of BD and the mechanisms of action of tDCS.…”
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Case report: Trauma-induced Klebsiella pneumoniae invasive syndrome presenting with liver abscess, lung abscess, endophthalmitis, and purulent meningitis by Hong-qiao Chen, Zhen-hua Mo, Wu-xiao Wei

“…While extensive research has focused on the risk of KPIS in patients with underlying conditions such as diabetes, trauma-induced KPIS remains exceedingly rare, with limited understanding of its pathophysiology and clinical management. Trauma may facilitate invasive infections by disrupting immune barriers and compromising local tissue integrity, creating entry points for pathogens.Case presentationThis study reports a case of a 72-year-old male who developed multiple infections, including liver abscess, lung abscess, left endophthalmitis, and purulent meningitis, following a traumatic fall. …”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

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Ocular TGF-β, Matrix Metalloproteinases, and TIMP-1 Increase with the Development and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus by Lucia Saucedo, Isabel B. Pfister, Souska Zandi, Christin Gerhardt, Justus G. Garweg

“…Diabetic retinopathy (DR) is a sight-threatening late complication of diabetes mellitus (DM). Even though its pathophysiology has not been fully elucidated, several studies suggested a role for transforming growth factor- (TGF-) β, matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinase (TIMP) in the onset and progression of the disease. …”
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Transition from hypothyroidism to Graves’ disease, development of thyroid eye disease, progression to optic neuropathy after inpatient pulse therapy, and long-term administration o... by Koichiro Mizuochi, Yuji Hiromatsu, Yui Nakamura, Aya Sonezaki, Ayaka Adachi, Tamotsu Kato, Nobuhiko Wada, Tomohiro Kurose, Shiho Watanabe

“…In addition, MRI was useful for the evaluation of the pathophysiology of ophthalmopathy. This case report suggests that careful monitoring by both endocrinologists and ophthalmologists using CAS, ophthalmological assessments, TSAb measurement, and orbital MRI are useful for making treatment decisions for TED.…”
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Purtscher-Like Retinopathy by Rita Massa, Carolina Vale, Mafalda Macedo, Maria João Furtado, Miguel Gomes, Miguel Lume, Angelina Meireles

“…Purtscher-like retinopathy should not be neglected in complex clinical contexts. Its unclear pathophysiology determines an uncertain treatment strategy, but a meticulous follow-up is compulsory in order to avoid its severe complications.…”
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