miR-203 Expression in Exfoliated Cells of Tongue Coating Represents a Sensitive and Specific Biomarker of Gastroesophageal Reflux Disease by Xiuli Yan, Shengliang Zhu, Hui Zhang

“…MicroRNAs (miRNAs) have been implicated in the pathophysiology of numerous human diseases including gastroesophageal reflux disease (GERD). …”
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A Cyanotic Newborn with a Pink Right Upper Extremity by Matthias Beichl, Andreas Hanslik, Daniel Zimpfer, Judith Rittenschober-Boehm, Katrin Nagl, Ina Michel-Behnke

“…The special hemodynamic situation of this is discussed in terms of pathophysiology and as well as its impact on perioperative and surgical management.…”
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Comprehensive review of pollen-food allergy syndrome: Pathogenesis, epidemiology, and treatment approaches by Yukinori Kato, Taiyo Morikawa, Shigeharu Fujieda

“…This review highlights the current research landscape on the pathophysiology, epidemiology, and clinical aspects of PFAS. …”
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Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms by Z. Qu, Bernice L. Y. Cheuk, Stephen W. K. Cheng

“…Inflammation plays a key role in the pathophysiology of abdominal aortic aneurysms (AAAs). …”
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Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression by Jie Qi, Jianguo Cui, Baobin Mi, Xiaohong Yan, Wenwen Xu, Hui Ma, Qingtan Zhang, Fang Xu

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Evaluation of Serum Zonulin Level and Intestinal Permeability in Patients with Chronic Spontaneous Urticaria and the Relationship Between Serum Zonulin Level and Disease Severity by Simge Ünal, Selda Pelin Kartal, Ahmet Ozsoy, Fevzi Nuri Aydın

“…Conclusion:  The observed results suggest that increased intestinal permeability, as indicated by elevated zonulin levels, may play a crucial role in the pathophysiology of both CSU and angioedema. This association highlights the potential significance of intestinal permeability in the development and manifestation of these conditions. …”
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Association of sildenafil use with age-related macular degeneration: a retrospective cohort study by Nicola Jaime Adderley, Krishnarajah Nirantharakumar, Anuradhaa Subramanian, Alastair K Denniston, Wen Hwa Lee, Ji Eun Diana Han, Jesse Coker

“…Objective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. …”
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Stromal-Cell-Derived Factor-1 (SDF-1)/CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg Ischaemia by Teik K. Ho, X. Shiwen, D. Abraham, J. Tsui, D. Baker

“…This review will focus on the role of the SDF-1/CXCR4 system in the pathophysiology of PVD and discuss their potential as therapeutic targets for PVD.…”
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The correlation between heavy metal ions in blood and metabolic dysfunction-associated steatotic liver disease from 1999 to 2018 based on NHANES data by Haijun Ma, Ju Zhao, Jian Xu

“…These findings challenge the conventional understanding of these heavy metals as universally harmful and highlight the need for further research to unravel the complex interplay between environmental exposures and MASLD pathophysiology.…”
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An Overview of the Skin Microbiome, the Potential for Pathogen Shift, and Dysbiosis in Common Skin Pathologies by Anita Smith, Roberta Dumbrava, Noor-Ul-Huda Ghori, Rachael Foster, James Campbell, Andrew Duthie, Gerard Hoyne, Marius Rademaker, Asha C. Bowen

“…Further research using culture-independent techniques is needed for conditions involving microbial dysbiosis to advance our knowledge of skin disease pathophysiology and guide future management.…”
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Managing Chronic Neuropathic Pain: Recent Advances and New Challenges by Namrata Hange, Sujan Poudel, Saleha Ozair, Trissa Paul, Meghna Nambakkam, Rakchhya Shrestha, Farrah Greye, Sangam Shah, Yagya Raj Adhikari, Sangharsha Thapa, Pooja Patel

“…Hence, there is still a need to explore the various treatment modalities, emphasizing the cause and underlying pathophysiology of neuropathic pain. Conclusion. We recommend integrated multimodal treatment with the current treatment facility, including various medical disciplines. …”
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Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Neuroinflammation is important in the pathophysiology of several degenerative brain disorders. …”
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Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review by Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R. Wang, Peter D. Wang, Win-Ping Deng

“…In this review, we summarized the current status of stem cell therapies in OA pathophysiology and also highlighted the potential areas of further research needed in regenerative medicine.…”
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Extracellular cold-inducible RNA-binding protein in CNS injury: molecular insights and therapeutic approaches by Dmitriy Lapin, Archna Sharma, Ping Wang

“…Abstract Central nervous system (CNS) injuries, such as ischemic stroke (IS), intracerebral hemorrhage (ICH) and traumatic brain injury (TBI), are a significant global burden. The complex pathophysiology of CNS injury is comprised of primary and secondary injury. …”
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Ocular Manifestations of the Sturge–Weber Syndrome by Kiana Hassanpour, Ramin Nourinia, Ebrahim Gerami, Ghavam Mahmoudi, Hamed Esfandiari

“…Approximately, half of the patients with SWS manifest ocular involvement including glaucoma as the most common ocular abnormality followed by choroidal hemangioma (CH). The underlying pathophysiology of glaucoma in SWS has not been completely understood yet. …”
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Glyoxylate, a New Marker Metabolite of Type 2 Diabetes by Victoria J. Nikiforova, Pieter Giesbertz, Jan Wiemer, Bianca Bethan, Ralf Looser, Volker Liebenberg, Patricia Ruiz Noppinger, Hannelore Daniel, Dietrich Rein

“…Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Leprdb/db-/- mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P=0.034). …”
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Interleukin-18 and CD30 serum levels in patients with moderate-severe depression by Rosaria Alba Merendino, Antonio Enrico Di Rosa, Giuseppe Di Pasquale, Paola Lucia Minciullo, Carmela Mangraviti, Antonella Costantino, Antonella Ruello, Sebastiano Gangemi

“…These data strengthen the hypothesis that MSD disease is associated with an inflammatory response, mainly T-cell-helper type 1, and suggest an important role for IL-18 in the pathophysiology of MSD.…”
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Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis by Isabelle Linares, Kaihua Chen, Ava Saffren, Mehran Mansouri, Vinay V. Abhyankar, Benjamin L. Miller, Stefano Begolo, Hani A. Awad, James L. McGrath

“…Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. …”
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Mechanism of Transcranial Magnetic Stimulation in the Treatment of Neuropathic Pain by SUN Yu-jia, ZHANG Jun-feng, YAN Long, FAN Shi-yu, QIAN Yu-lin, CONG Shan, YU Tao

“…Neuropathic pain （NP） is a persistent and refractory chronic pain condition resulting from damage or disease within the somatosensory nervous system. Its complex pathophysiology，coupled with low clinical remission rates，significantly impairs the physical and mental well-being of affected individuals. …”
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Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension by Carmine Savoia, Lidia Sada, Luigi Zezza, Lorenzo Pucci, Francesco Maria Lauri, Alberto Befani, Alessandro Alonzo, Massimo Volpe

“…Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.…”
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