Regulation of adult-born and mature neurons in stress response and antidepressant action in the dentate gyrus of the hippocampus by Eri Segi-Nishida, Kanzo Suzuki

“…The dentate gyrus (DG) of the hippocampus has been implicated in the regulation of stress responses, and in the pathophysiology and treatment of depression. This review discusses the cellular changes caused by chronic stress and the cellular role of the DG in stress-induced behavioral changes and its antidepressant-like effects. …”
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Intestinal microbiota dysbiosis contributes to the liver damage in subchronic arsenic-exposed mice by Dong Ling, Luo Peng, Zhang Aihua

“…There is an extensive amount of evidence that links changes in the intestinal microbiota structure to the progression and pathophysiology of many liver diseases. …”
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Treatment of Medial Tibial Stress Syndrome according to the Fascial Distortion Model: A Prospective Case Control Study by Christoph Schulze, Susanne Finze, Rainer Bader, Andreas Lison

“…There is no proven theory that could explain the pathophysiology of shin splints. The therapies described so far are time-consuming and involve a high risk of relapse. …”
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Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study. by Luigi Sacchettino, Michele Costanzo, Iolanda Veneruso, Valeria D'Argenio, Maria Mayer, Francesco Napolitano, Danila d'Angelo

“…Overall, our preliminary and integrated investigations highlighted an intriguing role for the microbiome-metabolome network, allowing to further unveil the potential pathophysiology of relational issues in companion animals and paving the way for more effective therapeutical approaches.…”
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Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…Recent advancements in understanding OA pathophysiology have spurred the development of innovative therapeutic strategies targeting disease progression. …”
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Self-administration of augmentation therapy for alpha 1-antitrypsin deficiency by A. Vianello, S. Lococo, L. Corda, M. Torrazza, G. Zuccarini, P. Baderna, F. Cinetto, E. Bargagli, P. Confalonieri, S. Sanduzzi Zamparelli, L. Bertagna De Marchi, B. Molena, F. Lionello, M. Caminati, G. Guarnieri

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Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder by Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman

“…Thus, it remains unknown if there are differences in treatment outcomes between patients with and without UUI and whether these differences are driven by pathophysiological processes. This narrative review highlights what is known about the pathophysiology of urgency, how urgency affects individuals with OAB, urgency measurement and associated challenges, and assessment of urgency in clinical trials.…”
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Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and prog... by Michaela Prchal-Murphy, Julia Zehenter, Marlene Fischer, Anita Pirabe, Madeleine Themanns, Behnaz Afrashteh, Eva Maria Putz, Karoline Kollmann, José Basílio, José Basílio, Manuel Salzmann, Wolfgang Strohmaier, Günther Krumpl, Alex Farr, Veronika Sexl, Michael Freissmuth, Eva Zebedin-Brandl

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Cardiac diffusion-weighted and tensor imaging: A consensus statement from the special interest group of the Society for Cardiovascular Magnetic Resonance by Erica Dall’Armellina, Daniel B. Ennis, Leon Axel, Pierre Croisille, Pedro F. Ferreira, Alexander Gotschy, David Lohr, Kevin Moulin, Christopher T. Nguyen, Sonja Nielles-Vallespin, William Romero, Andrew D. Scott, Christian Stoeck, Irvin Teh, Elizabeth M. Tunnicliffe, Magalie Viallon, Victoria Wang, Alistair A. Young, Jürgen E. Schneider, David E. Sosnovik

“…Despite the ongoing challenges discussed in the document and the need for ongoing technical improvements, it is clear that cDTI is indeed feasible, can be accurately and reproducibly performed and, most importantly, can provide unique insights into myocardial pathophysiology.…”
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Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of <i>Crotalus durissus ruruima</i> Venom and Antivenom Efficacy by Poliana J. Demico, Isabele N. Oliveira, Vitória S. Proença-Hirata, Samuel R. Dias, Hugo A. Ghirotti, Elisangela O. Silva, Inês C. Giometti, Francis L. Pacagnelli, Kristian A. Torres-Bonilla, Stephen Hyslop, Nathália C. Galizio, Karen de Morais-Zani, Manuela B. Pucca, Anderson M. Rocha, Jéssica B. Maciel, Marco A. Sartim, Wuelton M. Monteiro, Rafael S. Floriano

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Stem cells for age-related macular degeneration by L.K. Moshetova, O.I. Abramova, I.N. Saburina, K.I. Turkina

“…</i> </p> <p> <i>³Institute of General Pathology and Pathophysiology.&nbsp;<br> 8, Baltijskaya Str., Moscow, 125315, Russian Federation.…”
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Intestinal butyric acid-mediated disruption of gut hormone secretion and lipid metabolism in vasopressin receptor-deficient mice by Kazuki Harada, Eiji Wada, Yuri Osuga, Kie Shimizu, Reiko Uenoyama, Masami Yokota Hirai, Fumihiko Maekawa, Masao Miyazaki, Yukiko K. Hayashi, Kazuaki Nakamura, Takashi Tsuboi

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Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice by Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos, Nikolas A Stevens, Masashi Hasegawa, Dan A Ganea, Chloé M Benoit, Jan Gründemann, Lia Y Min, Kalynn M Bird, Christian Schultz, Vann Bennett, Paul M Jenkins, Maren Engelhardt

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Uncovering the epigenetic regulatory clues of PRRT1 in Alzheimer’s disease: a strategy integrating multi-omics analysis with explainable machine learning by Fang Wang, Ying Liang, Qin-Wen Wang

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Metabolomic and lipidomic pathways in aneurysmal subarachnoid hemorrhage by Bosco Seong Kyu Yang, Spiros L. Blackburn, Philip L. Lorenzi, Huimahn A. Choi, Aaron M. Gusdon

“…Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. …”
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Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines by Mervin Chávez-Castillo, Victoria Núñez, Manuel Nava, Ángel Ortega, Milagros Rojas, Valmore Bermúdez, Joselyn Rojas-Quintero

“…Nevertheless, views on the pathophysiology of depression have evolved notably, and the comprehension of depression as a complex neuroendocrine disorder with important systemic implications has sparked interest in a myriad of novel neuropsychopharmacological approaches. …”
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Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications by Lili Zhang, Jinjin Chu, Wenhao Hao, Jiaojiao Zhang, Haibo Li, Chunjuan Yang, Jinghan Yang, Xiaohua Chen, Honggang Wang

“…Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). …”
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The Relevance and Potential Role of Orbital Fat in Inflammatory Orbital Diseases: Implications for Diagnosis and Treatment by Prince Dadson, Peter Ngum, Luis Eduardo Juarez-Orozco, Michael Ntodie, Piotr Loba

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The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments by Yani Liu, Yanyan He, Shizhen Lei

“…Conclusion: Our findings indicated the important role of cuproptosis and a cuproptosis-related gene, CDKN2A, in the development and progression of THCA, which might provide novel insights into the understanding of pathophysiology of THCA.…”
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The impact of two Ginseng administrations on stress from acute physical effort by Ramona-Niculina Jurcău, Dong Hun Kwak, Ioana-Marieta Jurcău, Nicolae-Alexandru Colceriu, Cezar Honceriu

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