The Enteric Nervous System and Its Emerging Role as a Therapeutic Target by Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin

“…This review will provide a general overview of the ENS to date and connect specific GI diseases including short bowel syndrome with neuronal pathophysiology and current therapies. Exciting opportunities in which the ENS could be used as a therapeutic target for common GI diseases will also be highlighted, as the further unlocking of such mechanisms could open the door to more therapy-related advances and ultimately change our treatment approach.…”
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Severe, but not moderate asthmatics share blood transcriptomic changes with post-traumatic stress disorder and depression. by Sandor Haas-Neill, Anna Dvorkin-Gheva, Paul Forsythe

“…This study reveals gene and pathway regulation that potentially drives the comorbidity between severe asthma, PTSD, and MDD and may serve as foci for future research aimed at gaining a better understanding of both the relationship between asthma and PTSD, and the pathophysiology of the individual disorders.…”
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Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome by Fei Gao, Lijun Qi, Zhongzhen Yang, Tao Yang, Yan Zhang, Hui Xu, Huan Zhao

“…Previous studies have suggested that metabolic glutamate and gamma-aminobutyric acid (GABA) receptors/circuits are two counter-balanced factors involved in FXS pathophysiology. More and more studies demonstrated that attenuated GABAergic circuits in the absence of FMRP are critical for abnormal progression of FXS. …”
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Recurrence of chronic encapsulated hematoma following cyst formation after stereotactic radiosurgery for brain arteriovenous malformations: a case report by Iñigo L. Sistiaga, Gregorio Catalán-Uribarrena, Silvia Gamba, Alejandro Carrasco, Laura Zaldumbide, Lorena Mosteiro, Iñigo Pomposo

“…The authors present a well-documented case report describing these late complications, adding evidence to the possible common pathophysiological mechanism underlying them, and illustrating an effective treatment modality when they occur. …”
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A standardized definition for right ventricular failure in cardiac surgery patients by Habib Jabagi, Alex Nantsios, Marc Ruel, Lisa M. Mielniczuk, André Y. Denault, Louise Y. Sun

“…This article provides an overview of RVF aetiology, pathophysiology, current diagnostic modalities, as well as a summary of existing RVF definitions. …”
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CEACAM5 exacerbates asthma by inducing ferroptosis and autophagy in airway epithelial cells through the JAK/STAT6-dependent pathway by Si Liu, Li Chen, Yunxiao Shang

“…This study focused on the role of bronchial epithelial cells in asthma pathophysiology.Methods Bioinformatics was used to identify key asthmarelated genes. …”
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Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats by Mohamed I. Saad, Maher A. Kamel, Mervat Y. Hanafi

“…Current theories of T2DM pathophysiology include a decline in β-cells function, a defect in insulin signaling pathways, and a dysregulation of secretory function of adipocytes. …”
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Posterior reversible encephalopathy syndrome: a case report and review of the literature by G. V. Urbonaitė, E. Audronytė, J. Valaikienė

“…Usually this condition manifests with acute neurological symptoms, such as headache, impaired consciousness, seizures and/or vision disturbances with fluctuations in arterial blood pressure, and neuroimaging abnormalities of bilateral subcortical vasogenic edema, usually seen in occipital lobes. The pathophysiology of this syndrome is still debated, however, it is thought that PRES develops due to the endothelial dysfunction. …”
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Induction of MASH in three-dimensional bioprinted human liver tissue. by Vaidehi Joshi, Dwayne Carter, Alice E Chen, Keith Murphy, J William Higgins, Mediha Gurel, Daisy Chilin Fuentes, Sara Brin Rosenthal, Kathleen M Fisch, Tatiana Kisseleva, David A Brenner

“…Additionally, the transcriptome of the MASH tissues differed significantly from the healthy tissues and more closely resembled the transcriptome of biopsies of MASH livers from patients Thus, this study has developed a MASH bioprinted liver tissue suitable for studies on pathophysiology and drug discovery.…”
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Equilibrium and Dynamic Osmotic Behaviour of Aqueous Solutions with Varied Concentration at Constant and Variable Volume by Ivan L. Minkov, Emil D. Manev, Svetla V. Sazdanova, Kiril H. Kolikov

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Interaction of GPER-1 with the endocrine signaling axis in breast cancer by Luis Molina Calistro, Yennyfer Arancibia, Marcela Alejandra Olivera, Sigrid Domke, Rodrigo Flavio Torres

“…The novel and complex relationship between GPER-1 and HPG implies a hormonal regulation with important homeostatic effects on general organ development and reproductive tissues, but also on the pathophysiology of cancer, especially breast cancer. Recent research points to a great versatility of GPER-1, interacting with classical estrogen receptors and with signaling pathways related to inflammation. …”
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WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma by Trishla Bhatnagar, Madiha Haider, Mohd Yasir Khan, Mohammad Zahid Ashraf

“…Limited studies have been done to explore the molecular pathophysiology of the disease, with rather limited studies involving transcriptomic analyzes. …”
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Posterior Reversible Encephalopathy Syndrome due to Hypomagnesemia: A Case Report and Literature Review by Mohamad Almoussa, Angelika Goertzen, Stephan Brauckmann, Barbara Fauser, Christoph W. Zimmermann

“…This case highlights the role of magnesium in the pathophysiology of PRES; thereby, underlying hypomagnesemia should be considered in every PRES case with unclear etiology.…”
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Crackle Pitch Rises Progressively during Inspiration in Pneumonia, CHF, and IPF Patients by Andrey Vyshedskiy, Raymond Murphy

“…In any case improved understanding of the mechanism of production of these common lung sounds may help improve our understanding of pathophysiology of these disorders.…”
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Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia by Anika Singh, Paul Shim, Sadaf Naeem, Shafiqur Rahman, Kabirullah Lutfy

“…Thus, understanding the mechanisms involved in the initiation and maintenance of the stress response is essential since it may reveal the underpinning pathophysiology of these disorders and may aid in the development of medication to treat stress-mediated diseases. …”
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Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis. by Fazal Shirazi, Dimitrios Farmakiotis, Yuanqing Yan, Nathaniel Albert, Kim-Anh Do, Dimitrios P Kontoyiannis

“…Fly models of obesity bear intriguing similarities to the pathophysiology of insulin resistance and diabetes in humans, and can provide new insights into the pathogenesis and treatment of infections in obese and diabetic patients.…”
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Tetanus Complicated by Dysautonomia: A Case Report and Review of Management by Nishant Sharma, Si Li, Metlapalli Venkata Sravanthi, Dan Kazmierski, Yichen Wang, Amit Sharma, Pragya Dhaubhadel

“…We also review the epidemiology, pathophysiology, and management of tetanus and discuss dysautonomia in the setting of tetanus.…”
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Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer by Xiao Li, Yanghao Tai, Shuying Liu, Yating Gao, Kaining Zhang, Jierong Yin, Huijuan Zhang, Xia Wang, Xiaofei Li, Dongfeng Zhang

“…This paved the way for future research, revealed the complex pathophysiology of gastric cancer, and introduced an effective new treatment.…”
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Posterior Reversible Encephalopathy Syndrome in a Patient with Newly Diagnosed HIV Infection and End Stage Renal Disease by Mohankumar Kurukumbi, Maria I. Castellanos, Amanda K. Crawford, Shreyas D. Gowdar, Annapurni Jayam-Trouth

“…Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome in which patients present with an acute or subacute clinical presentation of seizures, visual disturbances, headache, and altered mental status. The pathophysiology of PRES may be explained by endothelial dysfunction that leads to transudation of fluids and protein, resulting in vasogenic cerebral edema. …”
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Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications by Zach Sheffield, Priyanka Paul, Shraddha Krishnakumar, Dipanjan Pan

“…Multiplex WBSs that simultaneously target cortisol alongside other viable stress‐related biochemical markers (SBMs) can prove to be indispensable for understanding how psychological stress contributes to the pathophysiology of neuropsychiatric illnesses (NPIs) and, thus, lead to the discovery of new biomarkers and more objective clinical tools. …”
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