Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease by Tung D. Nguyen, Michael A. Winek, Mihir K. Rao, Shaiva P. Dhyani, Monica Y. Lee

“…Numerous studies attribute NE components in cytoskeletal-related cellular behaviors to insinuate dysregulation of nucleocytoskeletal feedback and nucleocytoplasmic transport as a mechanism of endothelial and vascular dysfunction, and hence implications for aging and vascular pathophysiology.…”
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Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli. by Jessica M Gilbertie, Breanna J Sheahan, Shelly L Vaden, Megan E Jacob

“…Additionally, the dog could prove to be a powerful model of IBC formation as they are natural models of UPEC-causing UTIs and have similar pathophysiology of IBC formation.…”
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Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy by Xingmei Yao, Hengjiang Guo, Mengyao Sun, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Hao Wang, Lina Xing

“…Transient receptor potential cation channel subfamily C, member 6 (TRPC6), a potential target of KL, is implicated in glomerular pathophysiology. Here, we sought to determine whether KL could protect against podocyte injury through inhibiting TRPC6 in DN. …”
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Crossroads of Neurology and Virology: The Neurological Manifestations of COVID-19 by Kirolos Eskandar

“…Relevant studies were selected based on their focus on the pathophysiology, clinical presentations, and long-term neurological outcomes of COVID-19. …”
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Modeling Musculoskeletal Disorders in Zebrafish: Advancements in Muscle and Bone Research by Luca Dalle Carbonare, Michele Braggio, Arianna Minoia, Mattia Cominacini, Maria Grazia Romanelli, João Pessoa, Natascia Tiso, Maria Teresa Valenti

“…Zebrafish (<i>Danio rerio</i>) have emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases. Key genes and biological processes in zebrafish that closely mirror those in humans, rapid development, and transparent embryos make zebrafish ideal for the in vivo studies of bone and muscle formation, as well as the molecular mechanisms underlying musculoskeletal disorders. …”
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Central Corneal Subepithelial Haze Following Keratoplasty With Interrupted Sutures: A Novel Clinical Finding by Kirat O, Hawsawi R, AlHilali S

“…Further studies are needed to better understand this complication’s pathophysiology.Keywords: keratoplasty, sutures, subepithelial, haze…”
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Secondary endolymphatic hydrops: a clinical and literature overview by Aïna Venkatasamy, Aïna Venkatasamy, Aïna Venkatasamy, Aïna Venkatasamy, Anne R. J. Péporté

“…This review provides a better understanding of the pathophysiology and etiologies of this intricate disease process, thereby facilitating the diagnosis and treatment of the affected patients.…”
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Prevention and treatment of cerebral vasospasm following aneurysmal subarachnoid hemorrhage by Kyle McGrath, Grace Hey, Ghaidaa Ebrahim, Noah Gilberstadt, David Mahan, Brandon Lucke-Wold

“…Post-hemorrhage cerebral vasospasm (PHCV) occurs through a complex pathophysiology, and numerous pharmacologic agents, including vasodilators, anti-inflammatories, and fibrinolytics, as well as endovascular techniques have been used to prevent and/or treat PHCV. …”
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Overview of multimorbidity research in India: a scoping review protocol [version 2; peer review: 2 approved] by Arpita Ghosh, Siaa Girotra, Parul Puri

“…These morbidities often have shared pathophysiology, which leads to a rise in coexisting health issues known as 'multimorbidity'. …”
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Evaluation of Tumour Necrosis Factor-Alpha and Interleukin-1beta in an Experimental Pyelonephritis Model Induced with Planktonic and Biofilms Cells of Pseudomonas aeruginosa by Rahul Mittal, Saroj Sharma, Sanjay Chhibber, Kusum Harjai

“…The findings of the present study may be relevant for the better understanding of disease pathophysiology and for the future developments of preventive strategies against pyelonephritis based on anti-inflammatory intervention.…”
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Rimegepant for the treatment of migraine by Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Migraine is a common form of primary headache, affecting up to 1 in every 6 Americans. The pathophysiology is an intricate interplay of genetic factors and environmental influence and is still being elucidated in ongoing studies. …”
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FDA’s approval of resmetirom (Rezdiffra): a breakthrough in MASH management by Muhammad Mazhar Azam, Sameen Mukhtar, Muhammad Haris, Fatima Laique, Suhaina Amir, Mubashir Mohiuddin, Bibek Giri

“…MASH is a growing global health concern, and resmetirom offers a novel therapeutic option by targeting liver pathophysiology through thyroid hormone receptor-beta activation. …”
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Role of Thyroid Hormone in Neurodegenerative Disorders of Older People by Arshag D. Mooradian, Michael J. Haas

“…In addition, there is a significant association between thyroid hormone (TH) levels and the degree of cognitive impairment in Parkinson’s disease (PD). The pathophysiology of TH-related neurodegeneration include changes in the blood–brain barrier, increased cellular stress, altered processing of β-amyloid precursor protein and the effect of TH on neuronal cell viability. …”
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Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds by Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni

“…Moreover, in the past few decades, discoveries in the pathophysiology of psychotic disorders have opened the way for experimenting with novel compounds that have alternative mechanisms of action, with some of them showing promising results in early trials. …”
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Vascular Endothelial Cell Function in Catastrophic Antiphospholipid Syndrome: A Case Report and Review of the Literature by B. Routy, T. Huynh, R. Fraser, C. Séguin

“…Discussion of the pathophysiology and avenues of future therapies in CAPS are reported.…”
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Advances in 3D printing combined with tissue engineering for nerve regeneration and repair by Weifang Liao, Yuying Shi, Zuguang Li, Xiaoping Yin

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Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis by Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti

“…Clinical implications of E-cadherin perturbations in host pathophysiology are emphasized; downregulation, proteolytic phenomena, abnormal localization/signaling and aberrant immune reactions are linked with a broad spectrum of pathology beyond infectious diseases. …”
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Kleptomania Induced by Venlafaxine by Kumi Sakurada, Masashi Nibuya, Kazuo Yamada, Seishu Nakagawa, Eiji Suzuki

“…We considered two possible mechanisms to explain the pathophysiology of kleptomania in the present case: (1) increased dopaminergic neural transmission due to the inhibited dopamine reuptake by the norepinephrine transporter with a high dose of venlafaxine or (2) enhanced serotonergic neural transmission by the inhibition of serotonin reuptake by venlafaxine. …”
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Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps. by Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Ok Sarah Shin, Il-Ho Park

“…Th2 inflammation and epithelial-mesenchymal transition (EMT) play crucial roles in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). …”
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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…Breakthroughs now allow the generation of structurally and cellularly complex intestinal models to better capture a wider range of intestinal pathophysiology. As the field develops and evolves, there is a need for standardized frameworks for generation, culture, storage, and analysis of intestinal organoids to ensure reproducibility, comparability, and interpretability of these preclinical and clinical studies to ultimately enable clinical translation.…”
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