Sarcolemma resilience and skeletal muscle health require O-mannosylation of dystroglycan by Jeffrey M. Hord, Sarah Burns, Tobias Willer, Matthew M. Goddeeris, David Venzke, Kevin P. Campbell

“…Next, we restored Pomt1 using gene transfer via AAV2/9-MCK-mPOMT1 and determined the effect on Pomt1skm pathophysiology. Results Our data showed that in Pomt1skm mice O-mannosylated DG is required for sarcolemma resilience, remodeling of muscle fibers and muscle tissue, and neuromuscular function. …”
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

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Baricitinib for the treatment of severe alopecia areata: results from a 52-week multicenter retrospective real-world study by Carlo A. Vignoli, Luigi Gargiulo, Luciano Ibba, Anna Balato, Mauro Barbareschi, Stefania Barruscotti, Giulia Bazzacco, Francesco Bellinato, Vittoria G. Bianchi, Valeria Boccaletti, Raffaele D. Caposiena Caro, Silvia M. Ferrucci, Alessandro Fraghì, Elisabetta Fulgione, Giuseppe Gallo, Paolo Gisondi, Isotta Giunipero di Corteranzo, Piergiorgio Malagoli, Angelo V. Marzano, Santo R. Mercuri, Diego Orsini, Pietro Quaglino, Simone Ribero, Antonio Costanzo, Alessandra Narcisi

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A Review of Age-related Macular Degeneration and Current Concepts in Management by Sahebaan Sethi

“…The two main subtypes of AMD, namely dry and wet, are discussed in detail, highlighting their clinical features, pathophysiology, and diagnostic techniques. The manuscript then focuses on the current management strategies for AMD. …”
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Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial by Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado

“…Research suggests that inflammation is an important mediator in the pathophysiology of anxiety disorders. In addition, women are more likely to develop an anxiety and depression disorder, in comorbidity with a wide spectrum of diseases related to the immune system. …”
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Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options by Wenjing Huang, Luwen Zhu, Wenjing Song, Mei Zhang, Lili Teng, Minmin Wu

“…This review highlights mechanistic insights on the MGBA in disease pathophysiology. This review summarizes the role of MGBA signaling in the development of stroke risk factors such as aging, hypertension, obesity, diabetes, and atherosclerosis, as well as changes in the microbiota in experimental or clinical populations. …”
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Uveitis associated with elevation of intraocular pressure – what is the optimal therapy? by Agnieszka Kubicka-Trząska

“…The aim of the article is to present the classification and contemporary knowledge about the pathophysiology and pharmacological management of uveitis associated with increased IOP.…”
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Glutaraldehyde-Polymerized Hemerythrin: Evaluation of Performance as an Oxygen Carrier in Hemorrhage Models by Anca D. Stoica, Vlad-Al. Toma, Ioana Roman, Bogdan Sevastre, Florina Scurtu, Radu Silaghi-Dumitrescu

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Longitudinal displacement in viscoelastic arteries:A novel fluid-structure interaction computational model, and experimental validation by Martina Bukač, Sunčica Čanić

“…    This work presents a first step in understanding the role of longitudinal displacement in physiology and pathophysiology of arterial wall mechanicsusing computer simulations.…”
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Mechanisms and Clinical Management of Ventricular Arrhythmias following Blunt Chest Trauma by Daniel H. Wolbrom, Aleef Rahman, Cory M. Tschabrunn

“…This review article will describe the mechanisms, pathophysiology, and treatment of ventricular arrhythmias that occur in both the acute and chronic stages following blunt chest trauma.…”
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An Unusual Presentation of Streptococcus gallolyticus in Infective Endocarditis by Laura Torres Cruz, Maryam Barkhordarian, Neenu Antony, Muhammad Yasir, Sai Priyanka Pulipaka, Ahmad Al-Awwa, Sameh Elias

“…Through our case report, we emphasize the importance of investigating uncommon sources like cellulitis when initial malignant workup is negative in streptococcus bacteremia and further elucidate the pathophysiology of streptococcus bacterial dissemination from nonmalignancy-related sources.…”
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Using cortical organoids to understand the pathogenesis of malformations of cortical development by Kellen D. Winden, Isabel Gisser, Mustafa Sahin

“…In this review, we highlight advances in understanding the pathophysiology of brain malformations using organoid models.…”
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A clinical dilemma, the diagnosis of ectopic pregnancy by Carlos Moya Toneut, Javier Cruz Rodríguez, Miguel Román Sarduy Nápoles

“…It is transcendental that the doctor knows the pathophysiology and the clinical elements in ectopic pregnancy, which can go to look in an exquisite interrogation and a detailed physical examination. …”
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Esophageal Motility Disorders: Current Concepts of Pathogenesis and Treatment by Peter J Kahrilas

“…Controlled therapeutic trials and pathophysiological observations are emphasized. Achalasia is a rare disease of failed lower sphincter relaxation and aperistalsis. …”
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SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases by Minoru Fujimoto, Tetsuji Naka

“…SOCS1 may be implicated in pathophysiology of the liver. The studies using SOCS1-deficient mice revealed that endogenous SOCS1 is critical for the prevention of liver diseases such as hepatitis, cirrhosis, and cancers. …”
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Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy by Dechuan Sun, Mona Amiri, Qi Meng, Ranjith R. Unnithan, Chris French

“…Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. Additionally, calcium functions as a ubiquitous second messenger involved in diverse cellular processes, from synaptic activity to intercellular communication, making it a potential therapeutic target. …”
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Clinical Usefulness of Atrioventricular Coupling in Cardiovascular Disease by Yang Lan, Li Zhenyi, Chen Ya, Chen Anni, Wang Xinqi, Jin Lin, Li Zhaojun

“…AV-Coupling plays a vital role in the pathophysiology and progression of cardiovascular diseases. …”
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Principles of diuretic therapy at liver cirrhosis by A. I. Dyadyk, T. Ye. Kugler, I. S. Malovichko, N. F. Yarovaya, I. V. Rakitskaya

“…Therapeutic approach for edema syndrome at LC should be based on series of fundamental steps: edema pathophysiology understanding; comprehensive investigation of patients; assessment of edema severity and presence of complications; awareness of pharmacological features of diuretic drugs, their interaction and side effects; albumin or plasma substitutes administration, use of vasoconstrictors, transjugular intrahepatic portosystemic shunting and liver transplantation when required.…”
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Hypertensive Crisis in Pregnancy with COVID19: Confirmed with rt-PCR for Nasopharyngeal Swab by Sajith Bandara, Anura Ruwanpathirana, Dhammika Nagodawithana, Samantha Alwis

“…The activation of RAAM plays a pivotal role in the pathophysiology of hypertensive emergencies. Hence, there is a theoretical possibility of hypertensive crisis associated with ACE2/RAAM dysfunction in pregnant mothers who have COVID19. …”
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Alcohol and Suicide: Neurobiological and Clinical Aspects by Leo Sher

“…Dopaminergic dysfunction may play an important role in the pathophysiology of suicidal behavior in alcoholism. Brain damage and neurobehavioral deficits are associated with alcohol use disorders and may contribute to suicidal behavior in persons with alcohol dependence or abuse. …”
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