The Complexity of Pain Management in Children Affected by Mucopolysaccharidoses by Sabrina Congedi, Chiara Di Pede, Maurizio Scarpa, Angelica Rampazzo, Franca Benini

“…Pain is a common feature in mucopolysaccharidoses. However, the pathophysiology of pain in this group of diseases is still unclear and genesis of pain is multifactorial. …”
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Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials by Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas, Fabio Facchinetti

“…Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5–10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. …”
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Nosocomial Methemoglobinemia Resulting from Self-Administration of Benzocaine Spray by Christopher Hoffman, Hawa Abubakar, Pramood Kalikiri, Michael Green

“…We review this case in detail in addition to discussing methemoglobinemia and its relevant biochemistry, pathophysiology, clinical presentation, and medical management. …”
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Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases by David H. Tian, Chamini J. Perera, Gila Moalem-Taylor

“…Animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) mimic many aspects of MS and GBS, respectively, and are well suited to study the pathophysiology of these autoimmune diseases. However, while much attention has been devoted to curative options, research into neuropathic pain mechanisms and relief has been somewhat lacking. …”
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Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? by Arunotai Siriussawakul, Lucinda I. Chen, John D. Lang

“…This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. …”
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Contemporary Evaluation and Management of the Diabetic Foot by Bauer E. Sumpio

“…Ulcers are breaks in the dermal barrier with subsequent erosion of underlying subcutaneous tissue that may extend to muscle and bone, and superimposed infection is a frequent and costly complication. The pathophysiology of diabetic foot disease is multifactorial and includes neuropathy, infection, ischemia, and abnormal foot structure and biomechanics. …”
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Heat Stroke in Physical Activity and Sports (English original version) by Yuri Hosokawa, William M Adams, Rebecca L Stearns, Douglas J Casa

“…This document provides a review of the current best medical practices and evidence on the epidemiology, pathophysiology, risk factors, recognition, treatment, prevention, and return to play recommendations for EHS, specifically as they relate to sport and physical activity.…”
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Prospective Five-Year Follow-Up of Patients with Schizophrenia Suspected with Parkinson’s Disease by Asako Yoritaka, Tetsuo Hayashi, Keiko Fusegi, Rie Inami, Nobutaka Hattori

“…This prospective study aimed at determining the underlying pathophysiology using detailed clinical and psychological assessments. …”
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Impact of Incretin-Based Therapies on Adipokines and Adiponectin by Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. …”
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Heat Stroke in the Era of Global Warming: A Call for Urgent Action by Ayesha Khan, Manahil Mubeen

“…This article reviews the pathophysiology, effects, treatment, and preventive strategies of HS management. …”
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CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…Chemokines and their receptors play important roles in the pathophysiology of many diseases by regulating the cellular migration of major inflammatory and immune players. …”
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Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose by Jorge Rico-Fontalvo, José Correa-Guerrero, María Cristina Martínez-Ávila, Rodrigo Daza-Arnedo, Tomás Rodriguez-Yanez, Amilkar Almanza-Hurtado, José Cabrales, Carmen Julia Mendoza-Paternina, Alvaro Frías-Salazar, Julio Morales-Fernández

“…The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients.…”
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TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury by Shubhayu Bhattacharyay, Florian D. van Leeuwen, Erta Beqiri, Cecilia A. I. Åkerlund, Lindsay Wilson, Ewout W. Steyerberg, David W. Nelson, Andrew I. R. Maas, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants

“…At the same time, specific dynamic markers of pathophysiology associated strongly with changes in treatment intensity and, upon mechanistic investigation, may improve the timing and personalised targeting of future care.…”
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Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT by Luisa Müller, Venkata A. S. Dabbiru, Lucy Rutten, Rinke Bos, Roland Zahn, Stefan Handtke, Thomas Thiele, Marta Palicio, Olga Esteban, Marta Broto, Tom Paul Gordon, Andreas Greinacher, Jing Jing Wang, Linda Schönborn

“…Therefore, these rAbs offer an attractive new option to study VITT pathophysiology.…”
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Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus by Stephen A. Myers, Alex Nield, Mark Myers

“…This previously unexplored concept would raise a whole new area of research into the pathophysiology of insulin resistance and introduce a new class of drug target with utility for diabetes pharmacotherapy.…”
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A Roadmap to the Brittle Bones of Cystic Fibrosis by Ashwini P. Gore, Soon Ho Kwon, Antine E. Stenbit

“…This article will review the pathophysiology, current clinical practice guidelines, and potential future therapies for treating CF-related bone disease.…”
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Strategies in the Surgical Management of Atrial Fibrillation by Leanne Harling, Thanos Athanasiou, Hutan Ashrafian, Justin Nowell, Antonios Kourliouros

“…An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. …”
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The impact of cardiac complications on COVID-19 outcomes by Yu. V. Rudenko, V. I. Mazur

“…The data from 65 articles published from 2020 to 2023 were reviewed, except one study on the pathophysiology of the coronavirus published in 2015. …”
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Nanomaterials in wound infeetion care for senile diabetes: current research and developments by Yiran Liu, Xue Bai, Hui Ren, Baofeng Guo

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Response to Plasmapheresis Measured by Angiogenic Factors in a Woman with Antiphospholipid Syndrome in Pregnancy by Karoline Mayer-Pickel, Sabine Horn, Uwe Lang, Mila Cervar-Zivkovic

“…An imbalance of angiogenic and antiangiogenic placental factors such as endoglin and soluble fms-like tyrosine kinase 1 has been implicated in the pathophysiology of preeclampsia. Extraction of these substances by plasmapheresis might be a therapeutical approach in cases of severe early-onset preeclampsia. …”
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