Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
Get full text

Memory Functioning in Obsessive-Compulsive Disorder by M. Abbruzzese, L. Bellodi, S. Ferri, S. Scarone

“…Our results do not demonstrate significant memory impairment in OCD patients but point to the possibility of frontal lobe dysfunction as a factor in the pathophysiology of OCD.…”
Get full text

Parkinson's Disease and Sleep/Wake Disturbances by Todd J. Swick

“…A discussion of the clinical aspects, pathophysiology, evaluation techniques, and treatment options for the sleep disorders that are encountered with PD is presented.…”
Get full text

Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications by Luke J Janssen

“…The tools used to study ion channels in ASM are described, and the investigations of the roles of ion channels in ASM physiology (autacoid-evoked depolarization and hyperpolarization) and pathophysiology (airway hyperresponsiveness) are summarized. …”
Get full text

The Utilization of Diagnostic Musculoskeletal Ultrasound in the Evaluation for Ischiofemoral Impingement: A Perspective for Rehabilitation Providers by Robert C. Manske, Chris Wolfe, Phil Page, Michael Voight, Beth Bardowski

“…This article reviews the anatomy of the IFS, the pathophysiology of IFI, and the use of MSKUS in diagnosing IFI, equipping rehabilitation professionals with the knowledge to integrate this valuable diagnostic tool into clinical practice.…”
Get full text

The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells by Tao Du, Ying-Jian Zhu

“…Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. …”
Get full text

In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders by Harry Pantazopoulos, Sabina Berretta

“…Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. …”
Get full text

Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish by Hui Lv, Bo Liu, Yongwen Qin

“…Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis. …”
Get full text

Alzheimer’s Type Neuropathological Changes in a Patient with Depression and Anxiety: A Case Report and Literature Review of Neuropathological Correlates of Neuropsychiatric Symptom... by Sumit Das

“…The author hopes that such a case will promote more in-depth studies into the pathophysiology of neuropsychiatric manifestations in AD.…”
Get full text

Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD by Kristy A. Fisher, Heidi Kiziah, Clara L. Villalba Alvarez

“…Despite its representation throughout literature, the pathophysiology of PTSD remains incompletely understood, thus contributing to broad, variable, and at times, experimental treatment options. …”
Get full text

Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders by Shihan Zhang, Shasha Tang, Yalei Liu, Binghua Xue, Qinyuan Xie, Lingyun Zhao, Huijuan Yuan

“…This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment.…”
Get full text

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration by Zhangfu Li, Honghao Yang, Yong Hai, Yunzhong Cheng

“…For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. …”
Get full text

Current Concepts of Immunology and Diagnosis in Amniotic Fluid Embolism by Michael D. Benson

“…Current thinking about pathophysiology has shifted away from embolism toward a maternal immune response to the fetus. …”
Get full text

Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update by Shane O’Sullivan, John F. Gilmer, Carlos Medina

“…This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition.…”
Get full text

One in a Million: A Case Report of Stiff Person Syndrome by Ruchi Yadav, Neeraj Abrol, Sima Terebelo

“…Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylase antibody (anti-GAD Ab) are strongly associated with this disease. …”
Get full text

Transdiaphragmatic Intercostal Herniation following Blunt Trauma by Debkumar Sarkar, Melissa Warta, Jason Solomon

“…The presentation, pathophysiology, and management of this rare clinical entity are discussed.…”
Get full text

Distribution and neurochemical characterisation of neurons containing neuregulin 1 in the enteric nervous system within the porcine small intestine by Puchała Łukasz, Gonkowski Sławomir, Rytel Liliana, Wojtkiewicz Joanna, Grzegorzewski Waldemar Jarosław

Get full text

Prevention and Regression of Atherosclerosis: Emerging Treatments by Aliosvi Rodríguez Rodríguez, Gretchen Rodríguez Jaime

“…Atherosclerosis destabilizes the normal protective mechanism provided by the endothelium and this mechanism has been involved in the pathophysiology of acute coronary disease and brain stroke. …”
Get full text

Serum Voriconazole Level Variability in Patients with Hematological Malignancies Receiving Voriconazole Therapy by Lalit Saini, Jack T Seki, Deepali Kumar, Eshetu G Atenafu, David EC Cole, Betty YL Wong, Andrea Božović, Joseph M Brandwein

Get full text

Cortical laminar necrosis triggered by hepatic encephalopathy and post-traumatic subarachnoid hemorrhage: Case report by Inas AL CHARE, Mickaël BONNAN

“…This finding refines the pathophysiology of metabolic CLN.…”
Get full text