Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations. Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
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Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population by Min Jin Go, Joo-Yeon Hwang, Dong-Joon Kim, Hye-Ja Lee, Han Byul Jang, Kyung-Hee Park, Jihyun Song, Jong-Young Lee

“…Post-GWAS functional characterization of these variants is further required to elucidate their pathophysiological roles and biological mechanisms.…”
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Bilateral Symptomatic Mucoid Degeneration of the Anterior Cruciate Ligament with Anterior Knee Pain but No Limited Knee Flexion by Koshiro Shimasaki, Tomokazu Yoshioka, Akihiro Kanamori, Masashi Yamazaki

“…Some case reports have been published; however, it is difficult to diagnose and is often underdiagnosed or misdiagnosed because of its pathophysiological ambiguity. We report a rare case of a patient diagnosed with bilateral mucoid degeneration of the ACL with AKP and no limited joint range of motion (ROM). …”
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Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction by Guoxing Li, Huilin Zhao, Zhe Cheng, Junjin Liu, Gang Li, Yongzheng Guo

“…Introduction: Despite the high morbidity and mortality, the effective therapies for heart failure with preserved fraction (HFpEF) are limited as the poor understand of its pathophysiological basis. Objective: This study was aimed to characterize the cellular heterogeneity and potential mechanisms of HFpEF at single-cell resolution. …”
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Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population by M. Hannich, H. Wallaschofski, M. Nauck, M. Reincke, C. Adolf, H. Völzke, R. Rettig, A. Hannemann

“…Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. …”
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Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity by Xiaochen Tang, Yanyan Wei, Jiaoyan Pang, Lihua Xu, Huiru Cui, Xu Liu, Yegang Hu, Mingliang Ju, Yingying Tang, Bin Long, Wei Liu, Min Su, Tianhong Zhang, Jijun Wang

“…The identification of CHR biotypes provides compelling evidence for the early manifestation of heterogeneity within the psychosis spectrum, suggesting that distinct pathophysiological mechanisms may underlie these subgroups.…”
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Assessment of XCI skewing and demonstration of XCI escape region based on single-cell RNA sequencing: comparison between female Grave’s disease and control by In-Cheol Baek, Soo Yeun Sim, Byung-Kyu Suh, Tai-Gyu Kim, Won Kyoung Cho

“…Conclusions These results could aid in understanding the immunogenetics of gender differences in various autoimmune disease pathophysiologies.…”
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Drug-Induced Myoclonus: A Systematic Review by Jamir Pitton Rissardo, Ana Letícia Fornari Caprara, Nidhi Bhal, Rishikulya Repudi, Lea Zlatin, Ian M. Walker

“…Based on the main clinical constellation of symptoms and pathophysiological mechanisms found in this study, DIM can be categorized into three types: type 1 (serotonin syndrome), type 2 (non-serotonin syndrome), and type 3 (unknown).…”
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Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review by Pietro Cappelletto, Claudia Accolla, Martina Preti, Tiziana Pisano, Carmen Barba, Renzo Guerrini

“…In addition, we provide insights into the current knowledge of the pathophysiological bases of psychiatric symptoms in children and adolescents with TLE. …”
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Electroencephalographic markers in Major Depressive Disorder: insights from absolute, relative power, and asymmetry analyses by Mehmet Akif Özçoban, Oğuz Tan

“…Despite extensive research, the pathophysiological mechanisms and effects of MDD on the brain remain unclear. …”
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Exploring the mechanism of berberine treatment for atherosclerosis combined with non-alcoholic fatty liver disease based on bioinformatic and experimental study. by Shushu Wang, Kachun Lu, Liwen Lin, Gaijie Li, Yuxin Han, Zhichao Lin, Qingmin Chu, Kunsheng Wu, Peijian Liu, Guiting Zhou, Rui Peng, Chuanjin Luo

“…Both conditions share common pathophysiological pathways including abnormal lipid metabolism and inflammation. …”
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Alpha synuclein overexpression can drive microbiome dysbiosis in mice by Timothy R. Sampson, Zachary D Wallen, Woong-Jai Won, David G. Standaert, Haydeh Payami, Ashley S. Harms

“…As such, several experimental rodent and non-human primate models of α-syn overexpression recapitulate some of the hallmark pathophysiologies of PD. These animal models provide an opportunity to assess how the gut microbiome changes with age under disease-relevant conditions. …”
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Cohort profile: the Halland osteoarthritis (HALLOA) cohort–from knee pain to osteoarthritis: a longitudinal observational study in Sweden by Ann Bremander, Maria L E Andersson, S Bergman, Katarina Aili, Emma Haglund

“…We also found that modifiable factors as increased visceral fat and total body fat were associated with increased pain sensitivity among individuals with knee pain.Future plans By studying possible pathophysiological mechanisms of OA over time, we aim to provide new insights on OA progression, identify usable preventive measures helping the clinicians in the management of the disease and improve health for the patients. …”
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Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations by Nelly Joseph-Mathurin, Olene Dorieux, Audrey Kraska, Anne Bertrand, Mathieu Santin, Nadine El Tannir El Tayara, Marc Dhenain

“…However these models do not mimic all the pathophysiological aspects of human diseases. Complementary models such as non-human primates are phylogenetically close to humans and thus more predictive of drug efficiency in humans. …”
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System Pharmacological Approach to Investigate and Validate Multitargeted and Therapeutic Effect of Furocoumarins of Apium graveolens L. for Treatment of Kidney Disease by null Yasheshwar, null Gaurav, Rustam Ekkbal, Prem Gupta, Rajendra Gyawali

“…Furocoumarins reduce kidney dysfunction and associated pathophysiological complications via the reduction of glomerular vascular rigidity, diabetic nephropathy, and oxidative and inflammatory stress. …”
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Diagnostic Utility of Serum Ascites Lipid and Protein Gradients in Differentiation of Ascites by Mukhyaprana Prabhu, Rahul Sai Gangula, Weena Stanley

“…To study the diagnostic utility of serum ascites lipid gradients and serum ascites protein gradients in pathophysiological differentiation of ascites. Settings and Design. …”
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Elevated troponin levels in an athlete: Myocardial infarction or a physiological reaction? by Janković Tamara, Đorđević Stefan

“…It has been recorded for years that intense physical activity is also linked to the release of troponin, even though the pathophysiological mechanism had not yet been described. …”
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Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis by Zhang Q, Zhao YX, Li LF, Fan QQ, Huang BB, Du HZ, Li C, Li W

“…This condition contributes to the formation of a distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by its unique pathophysiological mechanisms and clinical presentation. …”
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Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. by Meimei Xu, Shan Yuan, Xing Luo, Mengsi Xu, Guangze Hu, Zhe He, Xinyuan Yang, Rui Gao

“…These findings highlight the role of lncRNAs as multi-level regulators in the complex network of post-stroke mechanisms, providing novel insights into the pathophysiological processes of stroke.…”
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Progress in the Application of Resting-State Functional Magnetic Resonance Imaging in Chronic Nonspecific Low Back Pain by XU Ting, XUE Qin, LÜ Ying, TU Jianchun, DAI Dechun

“…The high incidence, recurrence rate, and disability rate of CNLBP prompt continuous exploration of its pathophysiological mechanisms. Resting-state functional magnetic resonance imaging (rs-fMRI) can reflect the intensity of neuronal activity to acertain extent and has unique advantages in the study of central mechanisms of CNLBP. …”
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