Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test by Tatyana Strekalova, Nataliia Markova, Elena Shevtsova, Olga Zubareva, Anastassia Bakhmet, Harry M. Steinbusch, Sergey Bachurin, Klaus-Peter Lesch

“…While deficient brain plasticity is a well-established pathophysiologic feature of depression, little is known about disorder-associated enhanced cognitive processing. …”
Get full text

MFG-E8 Knockout Aggravated Nonalcoholic Steatohepatitis by Promoting the Activation of TLR4/NF-κB Signaling in Mice by Jun Hu, Hui Du, Yinglin Yuan, Peipei Guo, Junxia Yang, Xinru Yin, Jin Liu, Shengwang Wu, Jingyuan Wan, Xia Gong

“…Nonalcoholic steatohepatitis (NASH) is the common liver disease characterized by hepatic steatosis, inflammation, and fibrosis; there are no approved drugs to treat this disease because of incomplete understanding of pathophysiological mechanisms of NASH. Milk fat globule-epidermal growth factor-factor 8 (MFG-E8), a multifunctional glycoprotein, has shown anti-inflammation and antifibrosis. …”
Get full text

Hypermethylation of Hif3a and Ifltd1 is associated with atrial remodeling in pressure-overload murine model by Keiko Abe, Tetsuo Sasano, Yurie Soejima, Haruhisa Fukayama, Shigeru Maeda, Tetsushi Furukawa

“…Abstract Atrial remodeling is a major pathophysiological mechanism of atrial fibrillation (AF). …”
Get full text

Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep a... by Liang Wang, Yuanqi Wang, Tiantian Jiao, Linghao Xu, Endong Ji, Sakibur Rahman Tapu, Yehong Liu, Jiming Li

“…Abstract Background Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism by which CPAP treatment improves the prognosis of patients with CHD and OSA remains unclear. …”
Get full text

Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery by Leslie M. Rickey, Liyuan Huang, David D. Rahn, Yvonne Hsu, Heather J. Litman, Elizabeth R. Mueller

“…Further research is necessary to elucidate the pathophysiologic mechanisms that explain the associations between these medical conditions and bladder function.…”
Get full text

Topical steroids as alternative to systemic hormonal treatment for inflammatory bowel diseases in pediatric practice by E. N. Fedulova, O. V. Shumilova, O. V. Fedorova, O. A. Tutina, G. V. Medyantseva

“…Etiopathogenesis of IBD represents the cascade of self-maintaining pathophysiological reactions: adaptive microcirculational, hypoxicmetabolic, autoimmune inflammatory and dysbiotic disorders emerging on a background of genetic features of the body under the effect of unfavorable environmental factors. …”
Get full text

Extracellular vesicle-mediated approaches for the diagnosis and therapy of MASLD: current advances and future prospective by Swasthika Gurjar, Ramanarayana Bhat A, Raghavendra Upadhya, Revathi P. Shenoy

“…With this aim, this review emphasizes an in-depth understanding of the origin of EVs and the pathophysiological alterations of these ectosomes and exosomes in various liver diseases. …”
Get full text

Investigation of the Pulmonary Artery Hypertension Using an Ad Hoc OpenFOAM CFD Solver by Francesco Duronio, Paola Marchetti

“…The analysis of the data confirmed the importance of CFD as a supportive tool in understanding, diagnosing, and monitoring the pathophysiological mechanisms underlying cardiovascular diseases, proving to be a powerful means for personalizing surgical treatments.…”
Get full text

Generalized Extension of Referred Trigeminal Pain due to Greater Occipital Nerve Entrapment by Jung-woo Hyung, Byung-chul Son

“…Generalized extension of referred pain due to GON entrapment is thought to involve two possible pathophysiologies. One is the possibility that generalized pain is caused by sensitization of third-order nociceptive neurons in the thalamus. …”
Get full text

Télémonitorage des grandes fonctions physiologiques chez les primates vigiles by Guy Germain

“…These systems should help characterizing the trends of certain physiological states (ethophysiological studies, field studies) or pathophysiologic states (pathology, pharmacology) quickly enough to alert the observers so that they can apply feedback corrective actions when necessary. …”
Get full text

Noninvasive Near-infrared Imaging of Fluorochromes within the Brains of Live Mice: An In Vivo Phantom Study by Jan Klohs, Jens Steinbrink, Till Nierhaus, Riad Bourayou, Ute Lindauer, Peyman Bahmani, Ulrich Dirnagl, Andreas Wunder

“…Near-infrared fluorescence (NIRF) imaging has great potential for studying physiological and pathophysiological processes noninvasively in several locations of the body. …”
Get full text

Clinical Characteristics of Children with Acute Post-Streptococcal Glomerulonephritis and Re-Evaluation of Patients with Artificial Intelligence by Emre LEVENTOGLU, Mustafa SORAN

“…Questions assessing the definition, epidemiologic characteristics, pathophysiologic mechanisms, diagnosis, and treatment of APSGN were answered correctly by ChatGPT 3.5. …”
Get full text

Auditory function in humans at high altitude. A scoping review. by Michela Masè, Andrea Viziano, Giacomo Strapazzon, Marco Alessandrini, Alessandro Micarelli

“…Future studies in larger populations, using standardized protocols and multi-technique auditory function evaluation, are needed to further characterize the spatio-temporal pattern of HA effects along the auditory pathways and clarify the pathophysiological implications and reversibility of the observed changes.…”
Get full text

Systemic immune-inflammation index and the short-term mortality of patients with sepsis: A meta-analysis by Lingbo Liang, Qiaoli Su

“… The systemic immune-inflammation index (SII) is a novel biomarker that reflects the balance between the host immune response and inflammation, two key pathophysiological processes involved in sepsis. This meta-analysis aimed to evaluate the relationship between SII at admission and short-term mortality in patients with sepsis. …”
Get full text

The Predictive Significance of Platelet‐to‐Lymphocyte Ratio for Miscarriage: A Systematic Review and Meta‐Analysis by Xiaoyi Wang, Yanfang Zhao, Yangyang Fan, Yun Liu

“…ABSTRACT Background Miscarriage is a common complication of pregnancy, and its underlying pathophysiologic mechanisms remains unclear. The platelet‐to‐lymphocyte ratio (PLR), a prothrombotic and inflammatory marker, has been controversially discussed as a potential predictor of miscarriage. …”
Get full text

Protective Effect of Hydroalcoholic Extract of Stachys pilifera on Oxidant-Antioxidant Status in Renal Ischemia/Reperfusion Injuries in Male Rats by Zahra Moslemi, Izadpanah Gheitasi, Amir Hossein Doustimotlagh

“…Reactive oxygen species are considered the major constituents involved in the biochemical and pathophysiological changes that were shown during kidney I/R. …”
Get full text

The role of TASK-1 and TRPV1 channels in the male reproductive system by Dawon Kang, Eun-A Ko

“…Therefore, we aim to discuss the critical role of ion channels, specifically focusing on TASK-1 and TRPV1 channels, in the physiological and pathophysiological functions of testicular cells.…”
Get full text

p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice by Kun Hou, Zhi-cheng Xiao, Hai-Long Dai

“…Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. …”
Get full text

Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…We focus on the pathophysiological aspects of atrial cardiomyopathy, the impact of gut microbiota dysbiosis on atrial structure and function, and therapeutic strategies exploring modulation of the microbiota for the treatment of atrial cardiomyopathy. …”
Get full text

Unusual Presentation of Type 1 Idiopathic Macular Telangiectasia by Zaïnab Bentaleb Machkour, Philippe Denis, Laurent Kodjikian

“…The description of more cases of bilateral type 1 IMT should be helpful to more precisely define the pathophysiologic mechanism that could be different from a localized Coats’ disease of the macula area.…”
Get full text