The first cases of collagenous sprue successfully treated with thioguanine by Chris J J Mulder, Gerd Bouma, Tom van Gils, Tine van de Donk, Foke van Delft, E Andra Neefjes-Borst

“…Evaluation of small bowel biopsies was performed by an expert pathologist.Results None of the patients had ever had coeliac-specific antibodies, and all were negative for HLA-DQ2 and HLA-DQ8 phenotype. …”
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Can Gastric Cancer Patients with High Mandard Score Benefit from Neoadjuvant Chemotherapy? by Wen-Zhe Kang, Bing-Zhi Wang, Deng-Feng Li, Zhi-Chao Jiang, Jian-Ping Xiong, Yang Li, Peng Jin, Xin-Xin Shao, Hai-Tao Hu, Yan-Tao Tian

“…The results were reviewed by a professional pathologist. The radiologist compared the tumor regression before and after chemotherapy by computed tomography (CT). …”
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Idiopathic giant cell myocarditis or cardiac sarcoidosis? A retrospective audit of a nationwide case series by Kaj Ekström, Anne Räisänen‐Sokolowski, Jukka Lehtonen, Hanna‐Kaisa Nordenswan, Mikko I. Mäyränpää, Markku Kupari

“…Conclusions Recognizing granulomas in or outside the heart remains a challenge for the pathologist. Given that CS and GCM are considered distinct diseases and granulomas exclusive of GCM, many cases of GCM, if thoroughly scrutinized, may need reclassification as CS. …”
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Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy by Waraphon Thongsang, Sompop Kuljarusnont, Suchanan Hanamornroongruang, Irene Ruengkhachorn

“…An expert gynecologic pathologist reviewed pathological slides. Data collected from medical records included demographic and gynecologic information, sonographic findings, and surgical and pathological outcomes. …”
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Concurrent Viewing of H&E and Multiplex Immunohistochemistry in Clinical Specimens by Larry E. Morrison, Tania M. Larrinaga, Brian D. Kelly, Mark R. Lefever, Rachel C. Beck, Daniel R. Bauer

“…<b>Conclusions:</b> Simultaneous staining and detection, as described here, provides the pathologist a means to evaluate complex multiplexed assays, while seated at the microscope, with the added multispectral imaging capability to support digital pathology and artificial intelligence workflows of the future.…”
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Gastric Precancerous Lesions: From Progenitor Cell and Microsatellite Instability to Clinical Interpretation of Gastric Cancer Risk by A. V. Kononov, V. A. Rubtsov, M. N. Parygina, A. G. Shimanskaya, S. I. Mozgovoi, E. G. Pomorgailo, M. V. Markelova, Yu. A. Fedotova

“…Determination of MSI can be used as an auxiliary study within a panel of biomarkers aimed to support the decision-making of a pathologist in the alternative of “indefinite for dysplasia” or “definite dysplasia — obligate precancer”.…”
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Prognostic role of mesangial IgM deposition in IgA nephropathy: a long-term cohort study by Gabriel Stefan, Simona Stancu, Adrian Zugravu, George Terinte-Balcan

“…They were followed until end-stage kidney disease (ESKD), death, or until the end of the study in January 2021, with a median follow-up of 7 years. An independent pathologist evaluated the IgM immunofluorescence pattern, Oxford MEST-C score, and transmission electron microscopy (TEM) lesions following a comprehensive protocol.Results In our cohort, 70% had mesangial IgM-positive deposits, while 30% were IgM-negative. …”
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Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer by Christian Arstad, Kristin Taskén, Paulo Refinetti, Ulrika Axcrona, Karl-Erik Giercksky, Per Olaf Ekstrøm

“…Mutations can be detected in areas before changes in tissue histopathology are evident to the pathologist.…”
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Patient‐Reported Fatigue Associated with Joint Histopathology in Rheumatoid Arthritis by Diyu Pearce‐Fisher, Melanie H. Smith, Bella Y. Mehta, Edoardo Spolaore, Edward DiCarlo, Dongmei Sun, Susan M. Goodman

“…Hematoxylin and eosin stains of sectioned synovium were systematically scored by a pathologist. Relationships between fatigue and studied variables were evaluated with Kendall's tau. …”
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Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…Based on pathology slide findings, a pathologist reclassified the diagnoses. Clinical presentation, tumor characteristics, and clinical outcomes of breast ‘NENS’ were reviewed retrospectively. …”
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Multifocality and Detectability of Prostate Cancer with 3-Tesla Multiparametric Magnetic Resonance Imaging: Correlation with Radical Prostatectomy Mapping Histopathology by Serdar Karadağ, Deniz Noyan Özlü, Ahmet Hacıislamoğlu, Ömer Yıldız, Halil Fırat Baytekin, Mithat Ekşi, Hakan Polat, Alper Bitkin, Ali İhsan Taşçı

“…All cases were evaluated histopathologically by a pathologist with ten years of experience in uropathology. …”
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Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis: Experimental Model by Blanca Martínez Soriano, Antonio Güemes, Guillermo Pola, Azucena Gonzalo, Pilar Palacios Gasós, Ana C. Navarro, Roberto Martínez-Beamonte, Jesús Osada, José J. García

“…We analyze the parameters of oxidative stress: malondialdehyde (MDA), 4-hydroxyalkenals (4-HDA), and carbonyls, degree of fat infiltration (analyzed by direct vision by a pathologist and by means of a computer program of image treatment), and serological parameters of lipid metabolism and hepatic damage. …”
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Relationship Between Short‐Term Outcomes and PD‐L1 Expression Based on Combined Positive Score and Tumor Proportion Score in Recurrent or Metastatic Head and Neck Cancers Treated W... by Akihiro Ohara, Taisuke Mori, Mai Itoyama, Kazuki Yokoyama, Shun Yamamoto, Ken Kato, Yoshitaka Honma

“…Methods R/M‐HNSCC patients receiving APA monotherapy from 2018 to 2021 with available samples were enrolled. An experienced pathologist evaluated CPS and TPS utilizing the PD‐L1 IHC 22C3 pharmDx assay. …”
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Histomorphological Study of Rodenticide Poisoning: An Autopsy-based Crosssectional Study from a Tertiary Care Centre, Krishnagiri, Tamil Nadu, India by P Narmadha Priya, Jayalakshmy Pechimuthu, V Palaniappan, Teleflo Boopathy, Jeevanandham Anbazhagan, Jeevitha Muniraj

“…Autopsy specimens, including the heart, lungs, kidneys, liver, spleen and brain, were preserved in formalin and subjected to gross and microscopic examination by a pathologist. Histopathological sections were stained with Haematoxylin and Eosin (H&E). …”
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Validation of the Polish version of the Functional Oral Intake Scale against flexible endoscopic evaluation of swallowing and the International Dysphagia Diet Standardization Initi... by Magdalena Milewska, Barbara Jamroz, Mariusz Panczyk, Joanna Chmielewska-Walczak, Tomasz Czernicki, Marta Dabrowska-Bender, Marcin Folwarski, Marcin Folwarski, Dorota Szostak-Wegierek

“…Inter-rater reliability between evaluations conducted by a dietitian (FOIS I) and a speech-language pathologist (FOIS II) demonstrated high consistency (tau = 0.995; p &lt; 0.001). …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…The accuracy in diagnosing IDH-mutant astrocytoma, oligodendroglioma, and IDH-wild-type glioblastoma was 0.66, surpassing the human pathologist average of 0.62 (0.54–0.67). In conclusion, GLISP is a two-stage AI framework for histology-based prediction of genetic events in adult gliomas, which is helpful in providing essential information for WHO 2021 molecular diagnoses.…”
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High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…Subtypes were classified, and the Ki67 interobserver diagnostic agreement between Counting Pathologist 1 (CP1) and CP2 was calculated using Cohen’s kappa coefficient at various cutoff values.ResultsThe Cohen’s kappa coefficient for interobserver agreement between CP1 and CP2 was κ = 0.586, indicating moderate agreement. …”
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Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
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Case Reports: The core of practice-based evidence by Antonio Villa

“…In the NEJM, there is a section called ‘Clinical Problem Solving’ in which the case is presented by an experienced clinician, whereas in the section ‘Case Records of the Massachusetts General Hospital’ the case is shown and discussed with a pathologist. The Lancet, publishes case reports in the section ‘Clinical Picture’, in which case reports are described with a simple presentation. …”
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