Use of Diagnostic Algorithms for *NTRK* Fusion-Positive Tumors in Pathology Institutes in Switzerland by Holger Moch, Gieri Cathomas, Milo Frattini, Wolfram Jochum, Erik Vassella, Laurence de Leval, Joachim Diebold, Christian Britschgi, Thomas McKee, Lukas Bubendorf

“…As the detection of *NTRK* gene fusion opens up new treatment options for patients, it is vital to ensure that the detection methods and diagnostic algorithms in pathology institutes are optimized and of high quality. Detection can be performed by immunohistochemistry, next-generation sequencing or by fluorescence *in situ* hybridization. …”
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How to Introduce Virtual Microscopy (VM) in Routine Diagnostic Pathology: Constraints, Ideas, and Solutions by Klaus Kayser, Stephan Borkenfeld, Gian Kayser

“…Until today, only a few pathology institutions take use of this new technology, although it is available since several years. …”
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Assessing the suitability of formalin-fixed paraffin-embedded (FFPE) tissue for genome-wide association studies (GWAS) by Julian Reingruber, Maximilian J. Krämer, Jessica Bigge, Pouria Dasmeh, Sandeep Grover, Stefanie Heilmann-Heimbach, Markus M. Nöthen, Nicole Kreuser, Ines Gockel, Lothar Veits, Michael Vieth, Paul Jank, Carsten Denkert, Carlo Maj, Timo Hess, Johannes Schumacher

“…The availability of formalin-fixed paraffin-embedded (FFPE) samples in pathology institutes provides a valuable resource for GWAS, but the use of this material poses significant challenges. …”
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Measurement system for medical ultrasonic pulse spectroscopy by K. P. RICHTER, P. LANGE, R. MILLNER, H. HEYNEMANN, M. I. RICHTER, H. PRESSLER, Th. DRESCHER, H. LETTERER

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Network quantification of EGFR signaling unveils potential for targeted combination therapy by Bertram Klinger, Anja Sieber, Raphaela Fritsche‐Guenther, Franziska Witzel, Leanne Berry, Dirk Schumacher, Yibing Yan, Pawel Durek, Mark Merchant, Reinhold Schäfer, Christine Sers, Nils Blüthgen

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Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS by Iwona Stelniec‐Klotz, Stefan Legewie, Oleg Tchernitsa, Franziska Witzel, Bertram Klinger, Christine Sers, Hanspeter Herzel, Nils Blüthgen, Reinhold Schäfer

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STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer by Di Dong, Zhe Zhou, Minglu Zhu, Zhiyuan Hou, Mo Chen, Jingjing Gong, Xuyang Zhao, Aohui Yan, Hui Liang, Yuxin Yin

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Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer by Mirvat Surakhy, Julia Matheson, David J. Barnes, Emma J. Carter, Jennifer Hughes, Claudia Bühnemann, Sabina Sanegre, Hans Morreau, Paul Metz, Charlotte J. Imianowski, Andrew Bassim Hassan

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Unilateral Hyperplasia of the Mandibular Condyle by N. N. Khanna, S. K. Gupta, P. C. Sood, S. Khanna

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Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract by Izabela Wocławek-Potocka, Paulina Rawińska, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Emilia Sinderewicz, Tomasz Waśniewski, Dariusz Jan Skarzynski

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A RUNX1: RUNX1T1 AML with a simultaneous false positive KMT2A rearrangement: FISH interpretation pitfalls by Chi Zhang, Xingping Lang, Lingfeng Liu, Nan Chen, Huafei Chen, Xiaojun Chen, Yongyan Chen, Liqin Jin, Chengyin Liu, Huan Wang, Ailin Fu, Sheng Xiao

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Unravelling efficient applications of agriculturally important microorganisms for alleviation of induced inter-cellular oxidative stress in crops by Chetan KESWANI, Hagera DILNASHIN, Hareram BIRLA, S.P. SINGH

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Risks of parasitic helminth disease outbreaks and influence of physico-chemical factors in flood prone areas of Yaoundé, Cameroon by Noura Efietngab Atembeh, Jean Patrick Molu, Jeanne Valerie Emvoutou Maboulou, Boris Fominyam, Rodrigue Nanfack Dongmo, Gabriel Bertrand Zambo, Emilie Tchinda Tiecheu, Jeannette Tombi, Lucia Nkengazong, Serge Hubert Zebaze Togouet, Jean Louis Essame Oyono

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The Number and Size of Invasion Areas in Mixed-Type Carcinoma in Female Dogs Are Associated with Regional Metastases by Fernanda Freitas Miranda, Ana Paula Vargas Garcia, Marina Possa dos Reys, Erica Almeida Viscone, Mayra Cunha Flecher, Michele Angela Rodrigues, Geovanni Dantas Cassali

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Immune-Endocrine Cross-Talk in Reproductive Biology and Pathology by António M. Galvão, Graça M. Ferreira-Dias, Anna Chełmonska-Soyta, Izabela Wocławek-Potocka, Dariusz J. Skarżyński

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Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis by Evelyn Ane Oliveira, Lize Amanda Basaglia Borges, Thaynan Cunha Vieira, Bárbara Jaime dos Santos, Fernanda Rezende Souza, Karen Yumi Ribeiro Nakagaki, Cristiana Buzelin Nunes, Geovanni Dantas Cassali

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A catalog of numerical centrosome defects in epithelial ovarian cancers by Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto

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LPS-Challenged TNFα Production, Prostaglandin Secretion, and TNFα/TNFRs Expression in the Endometrium of Domestic Cats in Estrus or Diestrus, and in Cats with Pyometra or Receiving... by Ewelina Jursza, Anna Z. Szóstek, Mariusz P. Kowalewski, Alois Boos, Kiyoshi Okuda, Marta J. Siemieniuch

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Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes by Victoria L. Haley, David J. Barnes, Ionel Sandovici, Miguel Constancia, Christopher F. Graham, Francesco Pezzella, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan

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Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence by Simon Burgermeister, Michail Orfanakis, Spiros Georgakis, Cloe Brenna, Helen Lindsay, Craig Fenwick, Giuseppe Pantaleo, Raphael Gottardo, Constantinos Petrovas

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