Epidemiology of Trypanosomiasis in Wildlife—Implications for Humans at the Wildlife Interface in Africa by Keneth Iceland, Kasozi, Zirintunda, Gerald, Ssempijja, Fred, Buyinza, Bridget, Alzahrani, Khalid J., Matama, Kevin, Nakimbugwe, Helen N., Alkazmi, Luay, Onanyang, David, Bogere, Paul, Ochieng, Juma John, Islam, Saher, Matovu, Wycliff, Nalumenya, David Paul, Batiha, Gaber El-Saber, Osuwat, Lawrence Obado, Abdelhamid, Mahmoud, Shen, Tianren, Omadang, Leonard, Welburn, Susan Christina

“…Major Trypanosoma spp. include Trypanosoma brucei rhodesiense Trypanosoma brucei gambiense, and Trypanosoma cruzi, pathogenic for humans, and Trypanosoma vivax, Trypanosoma congolense, Trypanosoma evansi, Trypanosoma brucei brucei, Trypanosoma dionisii, Trypanosoma thomasbancrofti, Trypanosma elephantis, Trypanosoma vegrandis, Trypanosoma copemani, Trypanosoma irwini, Trypanosoma copemani, Trypanosoma gilletti, Trypanosoma theileri, Trypanosoma godfreyi, Trypansoma simiae, and Trypanosoma (Megatrypanum) pestanai. …”
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Characteristics of the monkeypox virus isolate obtained from the first patient in Russia and its sensitivity to 7-[N-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo-[3.2.2.0... by Alena S. Ovchinnikova, Dmitrii A. Odnoshevsky, Alexey S. Kabanov, Sergey A. Bodnev, Oleg V. Pyankov, Oksana P. Os'kina, Maria V. Sivay, Andrey V. Bespalov, Tatyana V. Tregubchak, Larisa N. Shishkina, Oleg S. Taranov, Vladimir V. Zolin, Artemiy A. Sergeev, Alexander P. Agafonov

“…Conclusion. In this study, the pathogen of monkeypox was detected and identified using real-time PCR, NGS and electron microscopy, and the first imported case of this disease in Russia was confirmed. …”
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The role of mNGS in the diagnosis of talaromycosis and case series by Jing Zhao, Hui-Ting Su, Dong Zhang, Xue-Tong Li, Min-Ya Lu, Juan Du, Jia-Yu Guo, Yi Gao, Xin-Fei Chen, Dong-Hua Wen, Shi-Yu Jia, Yao Wang, Qi-Wen Yang

“…Emerging technologies, particularly mNGS, offer advantages such as rapid processing, high accuracy, and comprehensive pathogen coverage, significantly reducing the risk of missed diagnoses and facilitating timely intervention.…”
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Therapeutic effects of traditional Chinese medicine Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota by Xiaoxia He, Xiaofeng Yuan, Qilin Shu, Yayang Gao, Youli Chen, Yao Liu, Yao Liu, Yao Liu, Jian Xu, Jian Xu, Jian Xu, Yongping Zhang, Yongping Zhang, Yongping Zhang, Guoqiong Cao, Guoqiong Cao, Guoqiong Cao

“…It partially reversed stroke-induced intestinal barrier disruption and leakage, inflammation, dyslipidemia and oxidative stress, as well as the stroke-induced increase in pathogenic gut microbiota (e.g., Escherichia-Shigella, Enterococcus, Clostridium_innocuum_group) and decrease in beneficial microbiota (e.g., Lachnospiraceae, unclassified__f__Lachnospiracea and Ruminococcus_torques_group). …”
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Comparison of Secondary Metabolite Extraction Methods in <i>Hamelia patens</i> Jacq. and Their Inhibitory Effect on <i>Fusarium oxysporum</i> f. sp. <i>radicis-lycopersici</i> by Daniel Jafet Valle Ortiz, Dolores Guadalupe Aguila Muñoz, María del Carmen Cruz López, Diana Verónica Cortés Espinosa, Martha Rosales Castro, Fabiola Eloísa Jiménez Montejo

“…These findings highlight the importance of optimizing extraction methods and selecting specific plant parts to enhance bioactive compound efficacy, offering a sustainable approach to pathogen management.…”
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High Frequency of AIFM1 Variants and Phenotype Progression of Auditory Neuropathy in a Chinese Population by Hongyang Wang, Dan Bing, Jin Li, Linyi Xie, Fen Xiong, Lan Lan, Dayong Wang, Jing Guan, Qiuju Wang

“…To decipher the genotype-phenotype correlation of auditory neuropathy (AN) caused by AIFM1 variations, as well as the phenotype progression of these patients, exploring the potential molecular pathogenic mechanism of AN. A total of 36 families of individuals with AN (50 cases) with AIFM1 variations were recruited and identified by Sanger sequencing or next-generation sequencing; the participants included 30 patients from 16 reported families and 20 new cases. …”
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Distribution and species composition of potato viruses in the Novosibirsk region by V. S. Maslennikova, M. B. Pykhtina, K. A. Tabanyukhov, E. V. Shelikhova, K. I. Mosalev, A. V. Katokhin, A. A. Bondar, A. B. Beklemishev, M. I. Voevoda

“…As a result of monitoring, the following viruses were identified: PVY (potato virus Y), PVS (potato virus S), PVM (potato virus M) and PVX (potato virus X). The quarantine pathogen potato spindle tuber viroid (PSTVd) was not detected in any of the samples analyzed. …”
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The role of mycobacteremia screening in enhancing non-tuberculous mycobacteria detection in hospitalized persons with HIV by Mengjiao Miao, Hongyan Zhu, Ziyao Liu, Jinjin Yang, Yiting Zhang, Chenyu Ma, Jiamin Qin, Yaling Chen, Hongxia Wei, Wei Chen, Yongfeng Yang, Zhiliang Hu, Zhiliang Hu, Zhiliang Hu

“…Mycobacterium avium complex (MAC) was the predominant pathogen, representing 95% (95% CI, 86.7–98.3%) of positive blood cultures, though it accounted for only 66.2% (95% CI, 54.3–76.3%) of NTM species isolated from respiratory samples. …”
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Use of approved cefazolin based intramammary dry goat treatment and its effects on the milk microbiota by Delower Hossain, Filippo Biscarini, Valentina Monistero, Paola Cremonesi, Bianca Castiglioni, Anoar Jamai Masroure, Alessandro Marinoni, Sara Fusar Poli, Matteo Mezzetti, Maria Filippa Addis, Valerio Bronzo, Erminio Trevisi, Paolo Moroni

“…Differential abundance analyses identified non-pathogenic genera, such as Acinetobacter, Bacteroides, and Paracoccus, that varied between groups at different timepoints. …”
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Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment by Quanlong Wu, Mengyin Deng, Ruoyu Mao, Na Yang, Ya Hao, Manli Cao, Da Teng, Jianhua Wang

“…<i>Staphylococcus aureus</i>, a prevalent zoonotic pathogen, poses a significant threat to skin wound infections. …”
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Insights gained through real-time monitoring of porcine reproductive and respiratory syndrome virus and description of temporal trends based on laboratory data in Ontario, Canada by Tatiana Petukhova, Maria Spinato, Tanya Rossi, Michele T. Guerin, Cathy A. Bauman, Pauline Nelson-Smikle, Davor Ojkic, Zvonimir Poljak

“…Porcine reproductive and respiratory syndrome virus (PRRSV) is a prevalent pathogen that impacts the health of swine and is costly to the swine industry. …”
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LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress by Ying Yi, Min-Yu Wu, Kai-Tian Chen, An-Hai Chen, Lin-Qiu Li, Qin Xiong, Xian-Ren Wang, Wen-Bin Lei, Guan-Xia Xiong, Shu-Bin Fang

“…Oxidative stress-mediated damage to the stria vascularis (SV) is one of the pathogenic mechanisms of NIHL. Recent studies indicate that glycolysis plays a critical role in endothelial cells (ECs)-related diseases. …”
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Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…The third most common in all samples were sequences of the Proteobacteria type, which contains pathogenic and opportunistic bacteria. Sequences of the Actinobacteria type were, on average, the fourth most common. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…Moreover, key virulence genes such as cdtB, lpf and sef were also detected, in addition to Salmonella pathogenicity islands SPI-1 and SPI-2. This study reveals the prevalence of multidrug-resistant and virulent strains of Salmonella serovars in the markets of Yichuan city, posing a risk of human infections. …”
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Detection and subtyping of Blastocystis sp. in human and animal stool samples using high-resolution melting analysis by Ghodratollah Salehi Sangani, Ahmad Hosseini-Safa, Bibi Razieh Hosseini Farash, Pooria Salehi Sangani, Mehdi Zarean, Elham Moghaddas, Saeid Zoghdar Moghadam, Lida Jarahi, Ali Gholizadeh, Fariba Berenji

“…Transmission occurs via the fecal-oral route, with prevalence rates ranging from 20% in developed countries to over 60% in developing regions. Although the pathogenicity of Blastocystis remains debated, it has been detected in both symptomatic and asymptomatic individuals. …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…KEGG enrichment analysis of 547 differentially expressed genes (DEGs) indicated their involvement pathways related to disease resistance, including the biosynthesis of sesquiterpenes and triterpenes, JA biosynthesis, plant-pathogen interactions and the MAPK signaling pathway. …”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Compared with algorithm testing, upfront comprehensive testing detected a higher number of pathogenic molecular alterations/patient (median: five versus three, P = 0.0005), however no additional actionable alterations. …”
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Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells by Xiaoming Kang, Xiaoming Kang, Lu Ma, Lu Ma, Lu Ma, Jie Wen, Jie Wen, Wei Gong, Wei Gong, Xianlin Liu, Xianlin Liu, Yihan Hu, Yihan Hu, Zhili Feng, Zhili Feng, Qiancheng Jing, Qiancheng Jing, Yuexiang Cai, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng, Yong Feng, Yong Feng, Yong Feng, Yong Feng

“…While some studies have been conducted using animal models, its pathogenic mechanisms in humans remain unclear. TMEM43 is predominantly expressed in cochlear glia-like support cells (GLSs) and plays a vital role in gap junction intercellular communication. …”
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Invited review: Improved control of Johne's disease in dairy cattle through advancements in diagnostics, testing, and management of young stock by Larissa Martins, Karin Orsel, Razieh Eshraghisamani, Jose Miguel Hernández-Agudelo, A. Caroline Pereira, Waseem Shaukat, Ad P. Koets, John P. Bannantine, Caroline Ritter, David F. Kelton, Richard J. Whittington, Maarten F. Weber, Antonio Facciuolo, Navneet K. Dhand, Karsten Donat, Susanne Eisenberg, Miguel A. Salgado, John P. Kastelic, Jeroen De Buck, Herman W. Barkema

“…ABSTRACT: Johne's disease (JD; paratuberculosis) control programs have been regionally implemented across the globe, but few have successfully eradicated the pathogen (Mycobacterium avium ssp. paratuberculosis; MAP) causing this disease. …”
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Investigating the Pulmonary Host Response of <i>Acinetobacter baumannii</i> Infection-Associated Pneumonia by Metagenomic Next-Generation Sequencing by Mu-Jung Chou, Chih-Hung Cheng, Hui-Ching Wang, Ming-Ju Tsai, Chau-Chyun Sheu, Wei-An Chang

“…<b>Conclusions:</b> mNGS provides information not only on pathogen gene expression but also on host gene expression. …”
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