CRISPR-Based Programmable Nucleic Acid-Binding Protein Technology Can Specifically Detect Fatal Tropical Disease-Causing Pathogens by Md. Rashidur Rahman, Toma Rani Majumder, Md. Aminul Islam Apu, Alok K. Paul, Afrina Afrose, Biplab Kumar Dash

“…Diagnostic approaches capable of ultrasensitive pathogen detection from low-volume clinical samples, running without any sophisticated instrument and laboratory setup, are easily field-deployable, inexpensive, and rapid, and are considered ideal for monitoring disease progression and surveillance. …”
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Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

“…We conducted a 16S rRNA amplicon sequencing using a nanopore-based platform, alongside routine polymerase chain reaction (PCR) testing or bacterial culture, to compare its clinical performance in pathogen detection on CSF samples. Among 17 patients, nanopore-based sequencing, multiplex PCR, and bacterial culture detected potential bacterial pathogens in 47.1%, 0%, and 47.1% samples, respectively. …”
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Comment on “Mitochondrial Neurogastrointestinal Encephalomyopathy: Novel Pathogenic Mutation in Thymidine Phosphorylase Gene in a Patient from Cape Verde Islands” by Josef Finsterer

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Beyond the fever: shotgun metagenomic sequencing of stool unveils pathogenic players in HIV-infected children with non-malarial febrile illness by Patricia Nabisubi, Stephen Kanyerezi, Grace Kebirungi, Ivan Sserwadda, Mike Nsubuga, Grace Kisitu, Patricia Ntege Nahirya, Bonny Mulindwa, George P. Akabwai, Sylvia Nantongo, Adeodata Kekitiinwa, Edgar Kigozi, Nsubuga Moses Luutu, Fred Ashaba Katabazi, Leymon Kalema, Andrew Katabalwa, Daudi Jjingo, Gerald Mboowa

“…Bioinformatics analysis was conducted to identify and characterise the microbial composition and potential pathogenic taxa associated with NMFI using the CZID pipeline. …”
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Oral-Delivery Lactococcus lactis expressing cherry fusion lactoferrin peptides against infection of avian pathogenic Escherichia coli in chickens by Zhuoran Li, Xueying Wang, Dianzhong Zheng, Fuzhen Han, Yue Li, Han Zhou, Jiaxuan Li, Wen Cui, Yanping Jiang, Xiaona Wang, Weichun Xie, Lijie Tang

Subjects: “…Avian pathogenic Escherichia coli…”
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Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya by Irene N. Ogali, Paul O. Okumu, Erick O. Mungube, Jacqueline K. Lichoti, Stephen Ogada, Grace K. Moraa, Bernard R. Agwanda, Sheila C. Ommeh

“…The results showed that all three isolates are virulent, as assessed by the mean death time (MDT) and intracerebral pathogenicity index (ICPI) in specific antibody negative (SAN) embryonated eggs and 10-day-old chickens, respectively. …”
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Comment on the Recent Publication Entitled by Ellis et al. “Association Between Biliary Pathogens, Surgical Site Infection, and Pancreatic Fistula” by Marie-Julie Lardinois, Alain Pans, Jean-Noël Koch, Abdourahmane Kaba, Arnaud de Roover, Nicolas Meurisse

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Mechanisms of trematodiases pathogenicity: the presence of the secretory proteins from the liver fluke Opisthorchis felineus in the gallbladder tissues of the patients with chronic opisthorchiasis by M. Y. Pakharukova, A. V. Kovner, A. N. Trigolubov, E. N. Fedin, E. S. Mikhailova, S. G. Shtofin, A. I. Autenshlyus, V. A. Mordvinov

“…Excretory-secretory products of the parasite are considered to be key factors in host-parasite relationships and mediate pathogenic pleiotropic effects on the host organism.The aim of this study was to determine the helminthic proteins (thioredoxin peroxidase and glutathione-S-transferase) in the gallbladder tissues of the experimental animals and patients with opisthorchiasis disease. …”
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The exotic rust fungus Puccinia abrupta var. partheniicola on the invasive alien weed Parthenium hysterophorus in India: rediscovery and first report of an epiphytotic by Prakya Sreerama Kumar

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<i>Phytophthora</i> Species and Their Associations with Chaparral and Oak Woodland Vegetation in Southern California by Sebastian N. Fajardo, Tyler B. Bourret, Susan J. Frankel, David M. Rizzo

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Development of spring durum wheat cultivars resistant to stem rust in Western Siberia by V. S. Yusov, M. G. Evdokimov, L. V. Meshkova, D. A. Glushakov

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Pemberian Lyophilized Bacterial Lysat Pada Penderita Penyakit Paru Obstruktif Kronis Stabil Yang Memiliki Kolonisasi Potentialy Pathogenic Microorganism by Povi Pada Indarta, Irvan Medison, Russilawati Russilawati, Deddy Herman

“…Tujuan dari penelitian ini adalah untuk melihat efek pemberian vaksinasi Lyophilized bacterial lysat pada pasien yang telah diketahui jenis potentialy pathogenic microorganism (PPM).Metode: Desain penelitian uji klinis terbuka (open ckinical trial) pada pemberian Lyophilized bacterial lysate dibandingkan dengan Plasebo terhadap pasien PPOK dengan koloni PPM di poliklinik Paru RSUP Dr.M.Djamil Padang periode Januari sampai Juni 2017.Sampel diambil dengan teknik konsekutif (accidental sampling). …”
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Discovery of Novel Diagnostic Biomarkers for Common Pathogenic <i>Nocardia</i> Through Pan-Genome and Comparative Genome Analysis, with Preliminary Validation by Chaohong Wang, Xinmiao Jia, Ming Wei, Jun Yan, Qing Sun, Sibo Long, Maike Zheng, Yiheng Shi, Guanglu Jiang, Yan Zhao, Hairong Huang, Xinting Yang, Li Gu, Guirong Wang

“…Pathogens…”
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Extraction of Saponins from Xanthoceras sorbifolium Bunge Leaves Using Deep Eutectic Solvents and Their Inhibitory Activity against Postharvest Pathogenic Fungi by Xue LI, Xinyu CHU, Erzheng SU, Jiahong WANG

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Sotos syndrome with marked overgrowth in three Japanese patients with heterozygous likely pathogenic NSD1 variants: case reports with review of literature by Yohei Masunaga, Hiroyuki Ono, Yasuko Fujisawa, Kiyosu Taniguchi, Hirotomo Saitsu, Tsutomu Ogata

“…Thus, whole exome sequencing was performed to confirm the diagnosis, revealing a likely pathogenic c.6356A&gt;G:p.(Asp2119Gly) variant in NSD1 of patients 1 and 2, and a likely pathogenic c.6599dupT:p.…”
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Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein by Wenhui Lu, Baoli Sun, Jianyue Mo, Xiduo Zeng, Guanqun Zhang, Lianxiang Wang, Qingfeng Zhou, Ling Zhu, Zhili Li, Qingmei Xie, Yinzuo Bi, Jingyun Ma

“…The study found that QY1 had been gradually attenuated during the in vitro process. Pathogenicity study showed that pigs inoculated with QY1 P100 and P80 did not develop any significant PRRS clinic symptoms. …”
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Comparison evaluation of bacterial DNA extraction methods for improved molecular diagnostic accuracy of sepsis-causing pathogens in clinical whole blood samples by Byungjoon Na, Junghun Park, Sojin Park, Eunseon Park, Jimin Jang, Yu-Hee Kim, Jinyeop Lee, Hae-Sun Chung

“…Abstract Sepsis, a leading cause of mortality, requires rapid and accurate pathogen identification to ensure effective treatment. …”
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Characterisation of EfbA from the Endodontic Pathogen Enterococcus faecalis and Prediction of Immunodominant EfbA Epitope Peptides: An In-vitro and In-silico Study by Dev Arora, AS Smiline Girija, J Vijayashree Priyadharsini

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Hospital solid waste management strategies to prevent healthcare-associated infections from occupational exposure to bloodborne pathogens and improve occupational safety by Augusto Jorge Antonio Ibáñez-Cruz, Alejandra Micaela Elena Vergara-Florián, William C. Algoner

“…This research focused on reducing the risk of nosocomial infections in healthcare workers exposed to bloodborne pathogens. It was carried out at the private clinic and concentrated on properly managing hospital solid waste, with special attention to occupational health and safety. 400 health workers were trained online during six sessions, addressing biosafety, conditioning, segregation, storage, collection, and transportation of solid waste. …”
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Impact of COVID-19 pandemic measures on hospitalizations and epidemiological patterns of twelve respiratory pathogens in children with acute respiratory infections in southern China by Wei Wang, Xiaojuan Luo, Zhenmin Ren, Xiaoying Fu, Yunsheng Chen, WenJian Wang, Yanmin Bao, Yuejie Zheng, Ke Cao, Jiehua Chen

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