Clinical and microbiological analysis of risk factors for breakthrough bloodstream infection during Tigecycline Therapy by Sol Jin, So Yun Lim, Yun Woo Lee, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Eun Hee Song, Yong Pil Chong

“…The most frequently identified pathogen in breakthrough BSI was Klebsiella pneumoniae (22.8%), followed by Candida species (17.1%), Pseudomonas aeruginosa (16.3%), and Acinetobacter baumannii (14.6%). …”
Get full text

Resistance to causal agents of late blight and golden potato nematode of the modern cultivars of seed potatoes and their phytosanitary status in various agroclimatic zones of the E... by A. V. Khiutti, D. A. Rybakov, T. A. Gavrilenko, O. S. Afanasenko

“…The active expansion of foreign potato cultivars on the territory of the Russian Federation has led to a change in the dominant pathogen species and to the emergence of new pathotypes of causal agents of harmful potato diseases. …”
Get full text

Transmission of synthetic seed bacterial communities to radish seedlings: impact on microbiota assembly and plant phenotype by Simonin, Marie, Préveaux, Anne, Marais, Coralie, Garin, Tiffany, Arnault, Gontran, Sarniguet, Alain, Barret, Matthieu

“…These results confirm that the plant core microbiome includes pathogenic and not only commensal or mutualistic taxa. …”
Get full text

Adverse Events of the BCG (Bacillus Calmette–Guérin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity by Suleiman Al-Hammadi, Najla S. Alkuwaiti, Ghassan A. Ghatasheh, Huda Al Dhanhani, Hiba M. Shendi, Abdulghani S. Elomami, Farida Almarzooqi, Abdul-Kader Souid

“…This young infant was diagnosed at six months of age with “immunodeficiency type 19” (MIM#615617) due to homozygous nonsense variant, NM_000732.4 (CD3D):c.128G > A, p.Trp43∗ (variation ClinVar#VCV000643120.1; pathogenic). This variant creates premature stop-gain in CD3D (CD3 antigen, delta subunit, autosomal recessive; MIM#186790), resulting in loss-of-function. …”
Get full text

γ-Aminobutyric Acid (GABA) Metabolic Bypass Plays a Crucial Role in Stress Tolerance and Biofilm Formation in <i>C. sakazakii</i> ATCC 29544 by Jiangchao Wu, Yigang Yu, Fengsong Liu, Yifang Cao, Jiahao Ren, Yiting Fan, Xinglong Xiao

“…<i>Cronobacter sakazakii</i> is a foodborne pathogen characterized by its robust stress tolerance and ability to form biofilms, which facilitates its survival in powdered infant formula (PIF) processing environments for prolonged periods. …”
Get full text

Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression by Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin

“…The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. …”
Get full text

Endophytic Colletotrichum siamense for Biocontrol and Resistance Induction in Guarana Seedlings by Luana L. Casas, José O. Pereira, Pedro Q. Costa-Neto, José F. Silva, Lucas N. Almeida, Roberto A. Bianco, João L. Azevedo

“…Leaflets were randomly collected from each treatment group at 0, 48, 72, and 96 hours after pathogen inoculation and analyzed for total protein and enzyme production (POX, PAL, and CHI). …”
Get full text

Surveillance of tick-borne encephalitis virus foci in Slovakia: A seroprevalence study in ruminants combined with virus detection in ticks by Martina Ličková, Bronislava Víchová, Markéta Derdáková, Monika Sláviková, Sabína Fumačová Havlíková, Dana Zubriková, Diana Selyemová, Michal Chvostáč, Lucia Blaňarová, Viktória Čabanová, Veronika Vaňová, Lucia Šulejová, Jana Kerlik, Tomáš Szemes, Katarína Šoltys, Boris Klempa

“…The tick-borne encephalitis virus (TBEV) is an important human pathogen that causes tick-borne encephalitis, a potentially fatal neurological disease. …”
Get full text

Construction and Investigation of MicroRNA-mRNA Regulatory Network of Gastric Cancer with Helicobacter pylori Infection by Ping Yang, Junjie Liu, Tianci Yang, Lei Zhang, Peiyou Gong, Boqing Li, Xiuzhi Zhou

“…Helicobacter pylori (H. pylori) is a common human pathogen, which is closely correlated with gastric cancer (GC). …”
Get full text

Emergence of Carbapenem-Resistant <i>bla</i>_POM-1 Harboring <i>Pseudomonas otitidis</i> Isolated from River Water in Ghana by Frederick Ofosu Appiah, Samiratu Mahazu, Isaac Prah, Taira Kawamura, Yusuke Ota, Yohei Nishikawa, Mitsunori Yoshida, Masato Suzuki, Yoshihiko Hoshino, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito

“…Both strains harbored virulence factors able to induce pathogenicity through immune evasion. The efflux pump genes (<i>adeF</i>, <i>rsmA</i>, and <i>qacG</i>) were present in the genomes of all the strains used in this study. …”
Get full text

Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk by Wenxi Sun, Ping Sun, Jin Li, Qun Yang, Qing Tian, Shiting Yuan, Xueying Zhang, Peng Chen, Chuanwei Li, Xiaobin Zhang

“…This present study reveals a significant causal relationship between mitochondria-associated proteins and SCZ, offering valuable insights into the disease’s pathogenicity and identifying potential therapeutic targets for drug development.…”
Get full text

Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus by Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov

“…Respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections in children. …”
Get full text

Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons by Emma C. Robinson, Anastazja M. Gorecki, Samuel R. Pesce, Vaishali Bagda, Ryan S. Anderton, Bruno P. Meloni

“…Thereafter, this study examined the therapeutic potential of the neuroprotective CARP, R18D (18-mer of D-arginine), to prevent the aforementioned PD pathogenic processes through a cell-free thioflavin-T (ThT) assay and in cortical neurons. …”
Get full text

Antimicrobial Resistance Profile of E. coli Isolated from Raw Cow Milk and Fresh Fruit Juice in Mekelle, Tigray, Ethiopia by Haftay Abraha Tadesse, Netsenet Berhe Gidey, Kidane Workelule, Hagos Hailu, Seyfe Gidey, Abrha Bsrat, Habtamu Taddele

“…The current study supports the finding that raw milk and fruit juice can be regarded as critical source of pathogenic E. coli. This supports the need for strict monitoring and the implementation of effective hygienic and biosecurity measures in the whole food chain of these products as well as a prudent use of antimicrobials.…”
Get full text

Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…Abstract Background Lynch syndrome (LS)-associated colorectal cancer (CRC) always ascribes to pathogenic germline mutations in mismatch repair (MMR) genes. …”
Get full text

Epidemiology and Antimicrobial Resistance of Stenotrophomonas maltophilia in China, 2014–2021 by Hanli Wang, Shirong Li, Haoyu Ji, Yixin Hu, Susheng Zhou, Xingwu Chen, Zhiwei Lu, Qinghai You, Yusheng Cheng, Lei Zha

“…Abstract Introduction Stenotrophomonas maltophilia is an opportunistic pathogen associated with various nosocomial infections and is known for its intrinsic multidrug resistance. …”
Get full text

Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer by Yangfan Zhou, Liang Zhao, Meimei Cai, Doudou Luo, Yizhen Pang, Jianhao Chen, Qicong Luo, Qin Lin

“…Determining this relationship is crucial for identifying pathogenic processes and developing therapeutic strategies. …”
Get full text

Molecular Epidemiology and Genetic Evolution of Porcine Reproductive and Respiratory Syndrome Virus in Northern China During 2021–2023 by Na Yuan, Zuofeng Yang, Fengxia Lv, Lina Dou, Xiangqing Li, Baokai Zhao, Shishan Dong

“…Porcine reproductive and respiratory syndrome virus (PRRSV), an important pathogen affecting the pig industry, is an RNA virus with high genetic diversity. …”
Get full text

Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…<i>Penicillium expansum</i> is a ubiquitous pathogenic fungus that causes blue mold decay of apple fruit postharvest, and another member of the genus, <i>Penicillium chrysogenum</i>, is a well-studied saprophyte valued for antibiotic and small molecule production. …”
Get full text

Prevalence of Fabry Disease among Patients with Parkinson’s Disease by Alexandra Lackova, Christian Beetz, Sebastian Oppermann, Peter Bauer, Petra Pavelekova, Tatiana Lorincova, Miriam Ostrozovicova, Kristina Kulcsarova, Jana Cobejova, Martin Cobej, Petra Levicka, Simona Liesenerova, Daniela Sendekova, Viktoria Sukovska, Zuzana Gdovinova, Vladimir Han, Mie Rizig, Henry Houlden, Matej Skorvanek

“…Nevertheless, the GLA variant found in our cohort is classified as a variant of unknown significance. Therefore, its pathogenic causative role in the context of PD needs further elucidation, and these findings should be interpreted with caution.…”
Get full text