BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy by Feng Jiang, Jiayang Tang, Xiaoqi Wei, Hai Pan, Xinyi Fan, Peng Zhang, Shuzhen Guo

“…These two factors often interact, contributing to cardiac fibrosis, which is both a common manifestation and a pathogenic driver of adverse remodeling in DCM-induced heart failure. …”
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Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…In brief, estrogen promotes subcutaneous fat deposition over visceral fat and increases in mass via adaptive hyperplasia rather than pathogenic hypertrophy. This adipose tissue subsequently produces anti-inflammatory effects and inhibits metabolic dysfunction-associated fatty liver disease (MAFLD) and RAS activation, ultimately leading to decreased levels of hypertension in pre-menopausal females. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…Type 2 RTS patients with biallelic RECQL4 pathogenic variants have multiple skeletal anomalies and a significantly increased incidence of osteosarcoma. …”
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Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria by Jia-Hong Tian, Siyuan Huang, Ze-Han Wang, Juan-Juan Li, Xianhui Song, Ze-Tao Jiang, Bing-Sen Shi, Ying-Ying Zhao, Hui-Yan Zhang, Ke-Rang Wang, Xin-Yue Hu, Xinge Zhang, Dong-Sheng Guo

“…Abstract Pathogenic intracellular bacteria pose a significant threat to global public health due to the barriers presented by host cells hindering the timely detection of hidden bacteria and the effective delivery of therapeutic agents. …”
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Microscopic Observation of Proliferative Membranes in Fibrocontractive Retinal Disorders by Rino Frisina, Francesco Tessarolo, Ivan Marchesoni, Federico Piccoli, Emiliana Bonomi, Patrizio Caciagli, Edoardo Midena, Giandomenico Nollo

“…In this study, the authors investigated the morphological characteristics and cell composition of various types of surgically excised proliferative membranes and internal limiting membranes (ILMs), in order to provide new data supporting or challenging the pathogenic theories proposed until now. Sixty-nine specimens from 64 eyes of 64 consecutive patients were collected at surgery and subjected to a multilevel analysis by means of optical and electron microscopy. …”
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Phytochemical screening and anti-Helicobacter pylori activity of Bryophyllum pinnatum, Ocimum gratissimum and Vernonia amygdalina by Precious Egharevba, Emilia Igue, Kingsley Enerijiofi, Orhue Amengialue

“…Helicobacter pylori, a common gastrointestinal bacterial pathogenic isolate infects 50% and 90% of the global and developing nations population respectively. …”
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Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early‐Stage Nonsmoking Lung Adenocarcinoma Patients by Yaohui Sun, Zhiming Gan, Shijiancong Liu, Sheng Zhang, Wei Zhong, Jian Liu, Xiuting Huang, Wei He, Hongcheng Zhong, Qingdong Cao

“…Conclusions Our study demonstrates that the interactions between the mycobiome and transcriptome within tumors may help elucidate the pathogenic mechanisms of ES‐LUAD. Fungi, as a potential predictive tool, can be used as an additional resource for accurately detecting and discriminating individuals with ES‐LUAD.…”
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Eco-friendly management of tomato wilt disease caused by Fusarium sp. in Sindh Province, Pakistan by Gul Poussio, Manzoor Abro, Rehana Syed, Muhammad Khaskheli, Jamal Hajano

“…The twelve different aqueous plant extracts were prepared and evaluated against test pathogen in laboratory, pots and in filed conditions.Results Among the tested aqueous plant extracts the neem seed, thorn apple, garlic, neem leaves and eucalyptus were found the most effective providing highest growth inhibition percent of test fungus. …”
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Circulation of Respiratory Syncytial Virus (RSV) in Poland Between Seasons of 2009/2010 and 2022/2023 Based on SENTINEL System by Karol Szymański, Anna Poznańska, Katarzyna Kondratiuk, Ewelina Hallmann, Katarzyna Łuniewska, Aleksander Masny, Lidia B. Brydak

“…Respiratory Syncytial Virus (RSV) is a prevalent pathogen of the respiratory tract, posing a significant threat to individuals with compromised immune systems, particularly the elderly and neonates in hospital settings. …”
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Characteristics of microbial contamination of animal raw materials and products in the Russian Federation from 2015 to 2018 by I. V. Borodkina, N. B. Shadrova, O. V. Pruntova, O. I. Ruchnova, Ye. S. Yerofeeva, S. I. Danilchenko, S. G. Yerofeev

“…The analysis performed showed that the maximum number of tests was performed for the following pathogenic microorganisms: Salmonella bacteria (29.5% within official monitoring and 26.8% within official programme). …”
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Harnessing the synergy of Urochloa brizantha and Amazonian Dark Earth microbiomes for enhanced pasture recovery by Anderson Santos de Freitas, Luís Felipe Guandalin Zagatto, Gabriel Silvestre Rocha, Franciele Muchalak, Guilherme Lucio Martins, Solange dos Santos Silva-Zagatto, Rogério Eiji Hanada, Aleksander Westphal Muniz, Siu Mui Tsai

“…This balance supported plant growth and increased the general availability of beneficial bacteria in the soil, such as Chujaibacter and Curtobacterium while reducing the presence of potentially pathogenic taxa. This research provided valuable insights into the intricate dynamics of plant-soil feedback, emphasizing the potential for complementary interactions between specific plant species and unique soil environments like ADEs. …”
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Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway by Min Li, Wenjia Tong, Chao Dai, Guoping Lu, Danqun Jin, Fang Deng

“…These findings reveal the pathogenic role of PSMB8 in AKI and suggest a novel therapeutic target for the condition.…”
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TRIM8 inhibits porcine epidemic diarrhoea virus replication by targeting and ubiquitinately degrading the nucleocapsid protein by Zhenbin Bi, Wei Wang, Shanshen Gu, Yajing Zhou, Zhengchang Wu, Wenbin Bao, Haifei Wang

“…Abstract Porcine epidemic diarrhoea virus (PEDV) is an enteric pathogen that causes acute diarrhoea, dehydration and high mortality rates in suckling pigs. …”
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Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

“…Since the known pathological changes caused by FFA2 are also implicated in cardiac hypertrophy, we hypothesized that FFA2 might be pathogenic in cardiac hypertrophy. This paper showed that FFA2 expression significantly increased in cardiac hypertrophy in vivo and in vitro. …”
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Genomic insights into a clinical Salmonella Typhimurium isolate carrying plasmid-mediated blaNDM-5 by Fan Huang, Genglin Guo, Lu Feng, Tongbo Cai, Xu Huang

“…Moreover, we conducted an epidemiologic analysis and focused on studying the mechanisms of plasmid-mediated blaNDM transmission, incorporating genomes deposited in the NCBI Pathogen Detection database. Results: The clinical isolate 23S9 belonged to serovar Typhimurium, antigenic profile 4:i:-, ST34, and carried pNDM_23S9 harbouring several antimicrobial resistance genes, including aac(6′)-Ib-cr6, OXA-1, catB3, arr-3, qacEdeltal and blaNDM. …”
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NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidia <i>Vairimorpha (Nosema) ceranae</i> by Pengfei Wang, Dufu Li, Qianmin Hai, Siming Liu, Yueyue Zhang, Jun Zhang, Jinshan Xu, Zhengang Ma, Zeyang Zhou

“…<i>Vairimorpha (Nosema) ceranae</i> is a pathogen that affects <i>Apis mellifera</i> and <i>Apis ceranae</i> Fabricius, capable of spreading within and between honeybee colonies. …”
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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy by Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang

“…Increased sST2 and IL-10 but not IL-33 may be involved in the pathogenic process of IgAN.…”
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Antimicrobial Effectiveness of Clove Oil in Decontamination of Ready-to-Eat Spinach (<i>Spinacia oleracea</i> L.) by Abigail A. Armah, Kelvin F. Ofori, Kenisha Sutherland, Emmanuel Otchere, Winter A. Lewis, Wilbert Long

“…This study assessed the antimicrobial activity of 5 and 10% (<i>v</i>/<i>v</i>) clove oil-amended wash liquid (CO) using a zone of inhibition (ZIB) test and determined the time required to completely inactivate pathogenic bacteria using bacterial death curve analysis. …”
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Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…Previous studies demonstrated that high, rather than low α-defensin level could modulate the local pro-inflammatory milieu of bronchial epithelial cells and macrophages promoting chronic inflammation and lower pathogen phagocytosis. IgG-mediated phagocytosis and NTHi adherence, engulfment and phagocytosis were measured in human alveolar macrophages and monocyte-derived macrophages (MDM) isolated from patients with AATD and from healthy individuals. …”
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Establishment of an indirect ELISA method for detecting bovine coronavirus antibodies based on N protein by Qiang Liu, Xiaoxia Niu, Lingling Jiang, Gang Zhang, Pu Wang, Sinong Zhang, Weifeng Gao, Huichen Guo, Huichen Guo, Yujiong Wang, Yong Li

“…Bovine Coronavirus (BCoV) is a significant pathogen responsible for neonatal calf diarrhea, winter dysentery in adult cattle, and bovine respiratory diseases. …”
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