Use of real-time polymerase chain reaction for investigation of Senecavirus infection occurrence in Russia by M. V. Timanov, A. M. Timina, M. V. Biryuchenkova

“…This is the first report on Senecavirus detection in the Russian Federation. The threat of the pathogen introduction from other countries requires further Senecavirus infection investigation and control. …”
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Analysis of the low density lipoprotein receptor gene (<i>LDLR</i>) mutation spectrum in Russian familial hypercholesterolemia by V. B. Vasilyev, F. M. Zakharova, T. Yu. Bogoslovskaya, M. Yu. Mandelshtam

“…Other regions are poorly studied. The majority of pathogenic mutations (142 out of 203 reported here or 70 %) were revealed in single pedigrees; 61 variants of mutations were described in two or more genealogies; only 5 mutations were found in 10 or more families. …”
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Selected microwave irradiation effectively inactivates airborne avian influenza A(H5N1) virus by Pietro Bia, Margherita Losardo, Antonio Manna, Silvio Brusaferro, Gaetano P. Privitera, Alberto Sangiovanni Vincentelli

“…Abstract The highly pathogenic avian influenza A(H5N1) virus threatens animal and human health globally. …”
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The Genetic Perspective of Familial Glucocorticoid Deficiency: In Silico Analysis of Two Novel Variants by Katayoun Heshmatzad, Nejat Mahdieh, Ali Rabbani, Abdolah Didban, Bahareh Rabbani

“…A comprehensive search was conducted to find the reported variants of MC2R and MRAP genes. In silico pathogenic analysis was performed for the reported variants. …”
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In Vitro Antibacterial Activities of Methanolic Extracts of Fruits, Seeds, and Bark of Zanthoxylum armatum DC by Nirmala Phuyal, Pramod Kumar Jha, Pankaj Prasad Raturi, Sangeeta Rajbhandary

“…The fruits, seeds, and bark extracts of Z. armatum exhibited remarkable antibacterial properties against different pathogenic bacteria causing several diseases, which suggests the potential use of this plant for treating different bacterial diseases such as skin infection, urinary tract infection, dental problems, diarrhea, and dysentery.…”
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Transcription factor TCF4: structure, function, and associated diseases by R. R. Savchenko, N. A. Skryabin

“…This review focuses on the TCF4 gene that encodes a transcription factor crucial for nervous system development and functioning. Pathogenic variants in this gene have been linked to a rare genetic disorder, Pitt–Hopkins syndrome, and TCF4 polymorphic variants are associated with several socially significant diseases, including various psychiatric disorders. …”
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Severe Pulmonary Infection in a 20-Month-Old Female by Yasmeen Mann, Paul Zeller, Kristen Carrillo-Kappus, Melissa Victor, Mary Moore

“…Seven days after second VATS, a respiratory pathogen panel was positive for rhinovirus/enterovirus. …”
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Identification of G-quadruplex-forming Sequences in Nucleocapsid Gene of SARS-CoV-2 Variants of Concern: An In Silico Analysis by Saeedeh Ghazaey Zidanloo

“…Therefore, due to the loss of this important PQS or indeed an obstacle to viral replication, the Delta variant could exhibit higher reproduction and pathogenicity than other variants of concern.…”
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Unveiling the prenatal features of HADDS: A case report and literature review by Lina Hu, Dongzhi Li, Li Zhen, Yanan Wang

“…The variant is a de novo shifted code mutation, which expands the pathogenic gene spectrum of EBF3. Furthermore, we did a retrospective analysis of HADDS patients with a history of pregnancy and childbirth. …”
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Interesting Cytokine Profile Caused by Clinical Strains of Pseudomonas aeruginosa MDR Carrying the exoU Gene by Nallely S. Badillo-Larios, Edgar Alejandro Turrubiartes-Martínez, Esther Layseca-Espinosa, Roberto González-Amaro, Luis Fernando Pérez-González, Perla Niño-Moreno

“…Pseudomonas aeruginosa is an opportunistic pathogen in HAIs with two facets: the most studied is the high rate of antimicrobial resistance, and the less explored is the long list of virulence factors it possesses. …”
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Streptococcus constellatus Peritonitis and Subsequent Septic Shock following Intrauterine Device Removal by Joan Tymon-Rosario, Jessica M. Atrio, Hyun Ah Yoon, David Erlichman, Veronica Lerner

“…Streptococcus constellatus is a highly pathogenic organism once a systemic septic infection has become established that can cause an ascending genital tract infection resulting in tubo-ovarian abscess formation, peritonitis, and septic shock.…”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…Legionella pneumophila is an intracellular pathogen that can cause Legionnaire’s disease by invading alveolar epithelial cells and macrophages. …”
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Changing Landscape of Haemophilus influenzae Meningitis and Implication on Public Health by John Allonce, Mohammed Ahsan, Angelina Browne, Rebecca Witherell, Mark Rasnake

“…Haemophilus influenzae (H. influenzae) has evolved as a prominent pathogen, with nontypeable strains (NTHi) emerging as a leading cause of invasive disease, particularly among the elderly. …”
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The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines by Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab

“…However, a consensus of studies agrees that the dominant form of this response is due to innate reactivity by macrophages to implant debris where both danger (DAMP) and pathogen (PAMP) signalling elicit cytokine-based inflammatory responses. …”
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Effectiveness of a commercial LAMP technology-based kit for rapid detection of Bursaphelenchus xylophilus in Pinus pinaster by María Menéndez-Gutiérrez, Lucía Villar, Raquel Díaz

“…Don under field conditions, thus contributing to the advancement of efficient surveillance and management strategies to combat this pathogen. Material and methods: In three different experiments, the detection rate of the B. xylophilus LAMP kit was compared to the traditional Baermann funnel technique for nematode extraction. …”
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Pangenome Analysis of Helicobacter pylori Isolates from Selected Areas of Africa Indicated Diverse Antibiotic Resistance and Virulence Genes by Biigba Yakubu, Edwin Moses Appiah, Andrews Frimpong Adu

“…As a result, this study compared the genomes of selected H. pylori isolates from selected areas of Africa and evaluated their virulence and antibiotic drug resistance, those that are highly pathogenic and are associated with specific clinical outcomes and those that are less virulent and rarely associated with clinical outcomes. 146 genomes of H. pylori isolated from selected locations of Africa were sampled, and bioinformatic tools such as Abricate, CARD RGI, MLST, Prokka, Roary, Phandango, Google Sheets, and iTOLS were used to compare the isolates and their antibiotic resistance or susceptibility. …”
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease by Zhu J, Zhang Z, Chu Y, Xie Z, Zeng D, Jin L, Li L

“…Jiamin Zhu,1,&ast; Zhen Zhang,1,2,&ast; Yanhui Chu,1,&ast; Zhongyin Xie,1 Dongmei Zeng,1 Lijiao Jin,1 Luxin Li1 1Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 2School of First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Luxin Li, Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157000, People’s Republic of China, Tel +86 13763617174, Email liluxin@mdjmu.edu.cnAbstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. Currently, therapies and their efficacy for kidney diseases are limited. …”
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Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea by Patthanasak Rungsirivanich, Elvina Parlindungan, Jennifer Mahony, Witsanu Supandee, Narumol Thongwai, Douwe van Sinderen

“…The ML061-4 genome was evaluated for genes associated with complex carbohydrate metabolism, bacterial adhesion, virulence factors, pathogenicity, bacteriophages, antiviral defence systems as well as toxin- and antibiotic-resistance associated genes, and genes involved in toxin production, secondary metabolite biosynthesis and xenobiotics biodegradation. …”
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Microcephalic osteodysplastic primordial dwarfism type II in four Indian children with PCNT variants by Amit Singh, Mahak Garg, Mohammed Shariq, Preeti Khetarpal, Inusha Panigrahi

“…Conclusion All four patients had significant microcephaly and growth retardation and the new variants were found to be likely pathogenic by in silico analysis. Early detection of the syndrome is essential for early interventions, proper genetic counseling and prenatal diagnosis.…”
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Recombinant SpTransformer proteins bind to specific sites on sea urchin phagocytes and modulate SpTransformer gene expression and immune responsiveness by Ryley S. Crow, Leon Grayfer, L. Courtney Smith

“…IntroductionThe California purple sea urchin, Strongylocentrotus purpuratus, relies exclusively on an innate immune system to survive in its pathogen rich marine environment. Central to this defense is the SpTransformer (SpTrf) gene family that is unique to the euechinoid group of echinoderms. …”
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