Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma by Yujuan Sun, Nan Liu, Xiaobing Guan, Hongru Wu, Zheng Sun, Hui Zeng

“…We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. The occurrence of regulatory T-cells (Tregs) and tumor-associated macrophages (TAMs) and the expression of anti-inflammatory cytokines and proinflammatory cytokines were investigated in OLK, OLP, and OSCC tissues. …”
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Pig herd management and infection transmission dynamics: a challenge for modellers by Sicard, Vianney, Picault, Sébastien, Andraud, Mathieu

“…The control of epidemics requires a thorough understanding of the complex interactions between pathogen transmission, disease impact, and population dynamics and management. …”
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Antimicrobial peptide AP2 ameliorates Salmonella Typhimurium infection by modulating gut microbiota by Lianglan Li, Qiufen Mo, Yi Wan, Yuanhao Zhou, Weiqin Li, Weifen Li

“…Abstract Background Endogenous antimicrobial peptides and proteins are essential for shaping and maintaining a healthy gut microbiota, contributing to anti-inflammatory responses and resistance to pathogen colonization. Salmonella enterica subsp. enterica serovar Typhimurium (ST) infection is one of the most frequently reported bacterial diseases worldwide. …”
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Liver diseases: epidemiology, causes, trends and predictions by Can Gan, Yuan Yuan, Haiyuan Shen, Jinhang Gao, Xiangxin Kong, Zhaodi Che, Yangkun Guo, Hua Wang, Erdan Dong, Jia Xiao

“…Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Furthermore, RT-qPCR revealed a substantial reduction of SPAG9 gene expression at the mRNA level in the affected individuals of both families, thus supporting the pathogenic nature of the identified variant. For the first time in the literature, biallelic SPAG9 gene variation was linked to multisystem-exhibiting features like coarse facial features, albinism, cataracts, skeletal abnormalities, and developmental delay. …”
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The mutational spectrum of NRAS gene discovers a novel frameshift mutation (E49R) in Saudi colorectal cancer patients by Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Abdulrahman Sibiany, Mohammed Saad Alamri, Samer Mohammed Hassan Alqarni, Irfan A. Rather, Adeel G. Chaudhary, Sajjad Karim, Peter Natesan Pushparaj

“…The aim of this study was to identify pathogenic mutations in the NRAS gene causing colorectal cancer in the Saudi population. …”
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Large Rearrangements in Genes Responsible for Familial Adenomatous Polyposis, <i>MUTYH</i>-Associated Polyposis and Peutz–Jeghers Syndrome in Russian Patients by A. N. Loginova, Yu. A. Shelygin, V. P. Shubin, A. M. Kuzminov, D. Yu. Pikunov, T. A. Saveleva, A. S. Tsukanov

“…Routine use of MLPA method makes it possible to increase the total frequency of detection of pathogenic variants in the APC and STK11 genes above 90 %. …”
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Establishment of a Mutant Library for Infection Cushion Development and Identification of a Key Regulatory Gene in <i>Botrytis cinerea</i> by Maoyao Tang, Kexin Wang, Pan Zhang, Jie Hou, Xiaoqian Yu, Hongfu Wang, Yangyizhou Wang, Guihua Li

“…Our findings provide valuable insights into the genetic and molecular basis of IC formation and offer new targets for controlling <i>B. cinerea</i> pathogenicity.…”
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Effects of Lactiplantibacillus plantarum HNU082 intervention on fungi and bacteriophages in different intestinal segments of mice by Xinlei Liu, Zhe Han, Wenyao Ma, Weipeng Cui, Dongyu Zhen, Shuaiming Jiang, Jiachao Zhang

“…The relative abundance of pathogenic fungi, such as Candida albicans, decreased in the small intestine. …”
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Outbreak of acute diarrhea in children: Clinical manifestations, treatment, source of drinking water, and fecal microbiome analysis in region of West Sumatra Province, Indonesia by Dianne Jurnalis Yusri, Yugatama Andyan, Azka Neila, Fenobileri Nice

“…Fecal samples identified Escherichia coli as the primary pathogen responsible for the outbreak. The findings emphasize the importance of nutrition status, prompt medical treatment including probiotics and proper antibiotics as an effective treatment protocol and highlight urgent need to enhance water quality and sanitation to prevent diarrhea outbreaks in the future.…”
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Recent advances in bacterial outer membrane vesicles: Effects on the immune system, mechanisms and their usage for tumor treatment by Shuo Xiang, Qiufang Yao, Arshad Khan, Dong Wang

“…Bacterial outer membrane vesicles (OMVs) secreted by gram-negative bacteria are nanoscale lipid bilayer structures rich in bacterial antigens, pathogen-associated molecular patterns (PAMPs), various proteins, and vesicle structures. …”
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IL-34 Suppresses Candida albicans Induced TNFα Production in M1 Macrophages by Downregulating Expression of Dectin-1 and TLR2 by Rong Xu, Hong-Fan Sun, David W. Williams, Adam V. Jones, Ali Al-Hussaini, Bing Song, Xiao-Qing Wei

“…Candida albicans is a fungus that is an opportunistic pathogen of humans. Normally, C. albicans exists as a harmless commensal and does not trigger inflammatory responses by resident macrophages in skin mucosa, which may be caused by a tolerance of skin macrophage to C. albicans. …”
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Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection by Cucunawangsih Cucunawangsih, Ratna Sari Wijaya, Nata Pratama Hardjo Lugito, Ivet Suriapranata

“… Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to increased vascular permeability, coagulopathy, and platelet dysfunction, a hallmark of severe dengue. …”
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In Situ Aqueous Spice Extract-Based Antifungal Lock Strategy for Salvage of Foley’s Catheter Biofouled with <i>Candida albicans</i> Biofilm Gel by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Kalidas Shetty, Adithya Rathish, Harshala Shivkumar, Malavika Gundreddy, Nikhil Kumar Kagganti Narendra, Nethra Machamada Devaiah

“…The study will provide an impetus to the development of novel spice extract-based ALT, reducing the selection pressure on the pathogen and lowering antimicrobial resistance. Further research in this area has the potential to leverage clinical applications.…”
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Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease by Wei Qin, Ping Nie, Xuejun Hui, Fei Chen, Xingbao Hu, Wenjiao Shi, Manyu Luo, Bing Li

“…Diabetic kidney disease is one of the common complications in diabetic patients and has gradually become an important pathogenic factor in chronic kidney disease. Therefore, studying the mechanisms of its occurrence and development is of great significance for the prevention and treatment of diabetic kidney disease. …”
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Aktivitas Daya Hambat Isolat Actinomycetes dengan Lama Fermentasi yang Berbeda terhadap Pertumbuhan Klebsiella pneumoniae by Annisa Nur Insani, Meiskha Bahar, Nunuk Nugrohowati, Retno Yulianti

“…Klebsiella pneumoniae is an opportunistic bacterial pathogen causing lower respiratory tract infection. …”
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SERINC5 counters retroviruses and non-retroviruses by Jinghua Yu, Jinghua Yu, Jinghua Yu, Chunyu Liu, Xinglong Qu, Xinglin Gao, Yue Liu

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Novel Polymorphism in a Promoter of MBL2 Gene Result in Lower MBL Expression in Chronic Infection Caused by HCV by Paywast Jamal Jalal

“…The Pathogen Recognition Receptors (PRRs) is an active protein in the immune system. …”
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Metabolic disorders as a factor in pathogenesis of infectious diseases in cattle by A. D. Alekseev

“…High-yielding dairy cows with intense metabolism are especially sensitive to errors in feeding practices, because even minor nutritional or mineral deficiencies cause metabolic disorders leading to immunodeficiency conditions, reduced resistance to infectious agents and raised sensitivity to infections with pathogenic and opportunistic microorganisms. Besides some infections, for example acute respiratory diseases, also result in metabolic disorders, immunosuppression, decrease in the overall resistance of the organism and ultimately in mixed infections. …”
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Effects of Lysozyme, Proteinase K, and Cephalosporins on Biofilm Formation by Clinical Isolates of Pseudomonas aeruginosa by Mohamed Eladawy, Mohammed El-Mowafy, Mohamed Mohamed Adel El-Sokkary, Rasha Barwa

“…Pseudomonas aeruginosa is an opportunistic pathogen that can form biofilms, which confer resistance to immune clearance and antibacterial treatment. …”
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