Morphological Features and In Vitro Cytopathic Effect of Acanthamoeba griffini Trophozoites Isolated from a Clinical Case by Arturo González-Robles, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Maria Reyes-Batlle, Carmen M. Martín-Navarro, Jacob Lorenzo-Morales

“…The phylogenetical analysis as well as the sequencing of the acquired amplified product for the DF3 region of the amoebae isolate confirmed that it belongs to genotype T3, which includes other pathogenic amoebae; besides the activity of two drugs currently used against Acanthamoeba was tested on A. griffini.…”
Get full text

Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway by Hei-Yin Tam, Jiaxing Liu, Tsz-Ching Yiu, Adrian On-Wah Leung, Chang Li, Shen Gu, Owen Rennert, Boxian Huang, Hoi-Hung Cheung

“…Abstract Background Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). …”
Get full text

Acinetobacter baumannii Lipopolysaccharide Influences Adipokine Expression in 3T3-L1 Adipocytes by Yuka Unno, Yoshinori Sato, Satoshi Nishida, Akiyo Nakano, Ryuichi Nakano, Tsuneyuki Ubagai, Yasuo Ono

“…Acinetobacter baumannii is one of the most important nosocomial opportunistic pathogen worldwide. In addition, obesity has been associated with an increased risk of nosocomial infection, suggesting that there may be an association between A. baumannii and white adipose tissue. …”
Get full text

Systematic expression analysis of cysteine‐rich secretory proteins, antigen 5, and pathogenesis‐related 1 protein (CAP) superfamily in Arabidopsis by Megumi Matsuzawa, Takumi Nakayama, Masa H. Sato, Tomoko Hirano

“…Although one of the plant CAP family genes, PR‐1 is known to respond to pathogen infection in plants, the functions of other CAP family genes in Arabidopsis remain largely unknown. …”
Get full text

Comparison of Biofilm and Attachment Mechanisms of a Phytopathological and Clinical Isolate of Klebsiella pneumoniae Subsp. pneumoniae by Adriana Marcia Nicolau Korres, Gloria Maria de Farias V. Aquije, David S. Buss, Jose Aires Ventura, Patricia Machado Bueno Fernandes, Antonio Alberto Ribeiro Fernandes

“…It is almost impossible to prevent the contact of clinically pathogenic bacteria with food crops, and if they can persist there, they can reenter the human food chain and cause disease. …”
Get full text

He-Plasma Jet Generation and Its Application for E. coli Sterilization by Tiejian Liu, Yuxuan Zeng, Xin Xue, Yinyi Sui, Yingying Liang, Fushan Wang, Fada Feng

“…Atmospheric pressure plasma jet (APPJ) is a promising technique for the sterilization of pathogenic microorganisms in an ambient environment. …”
Get full text

Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis? by Thomas Bertran, Patrick Brachet, Marjolaine Vareille-Delarbre, Julie Falenta, Annie Dosgilbert, Marie-Paule Vasson, Christiane Forestier, Arlette Tridon, Bertrand Evrard

“…We investigated the interactions between G. vaginalis and human monocyte-derived DCs using a wide range of bacterial concentrations (multiplicity of infection from 0.01 to 100), and the effects of this pathogen on PHA-induced lymphocyte proliferation. As observed by electron microscopy and cytometry, G. vaginalis reduced the internalization ability of DCs by forming extracellular clusters and induced neither DC maturation, nor DC secretion of cytokines, except at the highest dose with a very early DC maturation state. …”
Get full text

Glycosylation Patterns in <i>Meccus (Triatoma) pallidipennis</i> Gut: Implications for the Development of Vector Control Strategies by Elia Torres-Gutiérrez, Frida Noelly Candelas-Otero, Olivia Alicia Reynoso-Ducoing, Berenice González-Rete, Mauro Omar Vences-Blanco, Margarita Cabrera-Bravo, Martha Irene Bucio-Torres, Paz María Silvia Salazar-Schettino

“…Understanding glycosylation patterns provides critical insights into vector–pathogen interactions that could eventually inform novel control approaches. …”
Get full text

Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion by Liguo Zhang, Zhao Li, Yajing Fu, Haoyang Tian, Ting Wang, Hongrui Liu, Jianhua Li, Hong Liu, Shaohua Ge, Baojin Ma

“…Furthermore, the nanoengineered HAp layer deters pathogenic colonization due to the low adhesion force, which can effectively prevent the formation of bacterial biofilms and infection after implantation. …”
Get full text

Efficacy of Larimichthys crocea TASOR protein-derived peptide FAM286 against Staphylococcus aureus by Ritian Jin, Guanglei Wei, Rong Lin, Wenfeng Lin, Jude Juventus Aweya, Duo Liang, Wuyin Weng, Shen Yang

“…Staphylococcus aureus (S. aureus) is a major foodborne pathogen, could lead cause of intestinal infections in humans. …”
Get full text

Parathyroid carcinoma and pheochromocytoma in a patient with neurofibromatosis type 1: a rare association by Jardelina Brena Rocha Leite, Nicole Ramalho De Freitas, Rafaella Nelice de Holanda Cardoso, Erik Trovão Diniz, Gabriel Rodrigues de Assis Ferreira, Fernão Henrique Costa e Alvim, Camila Ribeiro Coutinho Madruga, Ana Carolina Thé Garrido, Luciano Albuquerque, Patricia Sampaio Gadelha, Ruy Lyra, Lucio Vilar

“…Genetic analysis corroborated NF1 with a pathogenic variant in the NF1 gene. The patient’s clinical manifestations, coupled with the presence of café-au-lait spots and axillary freckles, supported the diagnosis of NF1. …”
Get full text

Case report: Hypoparathyroidism-sensorineural hearing loss-renal dysplasia without febrile seizures: a novel mutation in the GATA3 gene by Haibin Chen, Haibin Chen, Yudi Zhang, Xueyao Yang, Xueyao Yang, Yongzhen Li

“…The missense mutation was determined to be both pathogenic and novel.ConclusionEarly genetic testing should be prioritized, and regular monitoring of kidney development and hearing status is essential. …”
Get full text

UV-C Radiation as a Factor Reducing Microbiological Contamination of Fish Meal by Krzysztof Skowron, Justyna Bauza-Kaszewska, Zbigniew Dobrzański, Zbigniew Paluszak, Karolina Jadwiga Skowron

“…Fish meals, added to feeds as a source of protein, may contain pathogenic bacteria. Therefore, effective methods for their sanitizing, such as UV-C radiation, are needed to minimize the epidemiological risk. …”
Get full text

Agricultural Technology for Phytophage and Phytopathogen Resistant Planting Material by Evgenia A. Dyukova, Ekaterina G. Ulyanova, Maria A. Osintseva, Victoria A. Kryuk

“…The study revealed the developmental stages of pine seedlings and the effect of pesticides on pathogen count. After phytosanitary monitoring and preventive treatments, the seedlings were tested for the effectiveness of pesticides, fungicides, and insecticides as part of pre-planting seed treatment. …”
Get full text

Development of a Luciferase Immunosorbent Assay for Detecting Crimean–Congo Hemorrhagic Fever Virus IgG Antibodies Based on Nucleoprotein by Qi Chen, Yuting Fang, Ning Zhang, Chengsong Wan

“…Classified as a level 4 biosecurity risk pathogen, CCHF can be transmitted cross-species due to its aerosol infectivity and ability to cause severe hemorrhagic fever outbreaks with high morbidity and mortality. …”
Get full text

Vaginal Dysbiosis in Infertility: A Comparative Analysis Between Women with Primary and Secondary Infertility by Iliana Alejandra Cortés-Ortíz, Gustavo Acosta-Altamirano, Rafael Nambo-Venegas, Jesús Alejandro Pineda-Migranas, Oscar Giovanni Ríos-Hernández, Eduardo García-Moncada, Alejandra Yareth Bonilla-Cortés, Mónica Sierra-Martínez, Juan Carlos Bravata-Alcántara

“…Objective: The aim of this study was to characterize the vaginal microbiota of 136 Mexican women diagnosed with infertility—primary (n = 58) and secondary (n = 78)—by evaluating the presence of pathogenic bacterial species and their associations with infertility conditions. …”
Get full text

Distribution and Genetic Diversity of Salmonella enterica in the Upper Suwannee River by Masoumeh Rajabi, Melissa Jones, Michael Hubbard, Gary Rodrick, Anita C. Wright

“…However, some Suwannee River isolates (12%) were clustered with these primarily clinically-associated genogroups, supporting the hypothesis that river water can serve as a disease reservoir and that pathogenic strains may persist or possibly originate from environmental sources.…”
Get full text

Ketamine-associated upper urinary tract dysfunction: What we know from current literature by Zhihuan Zheng, Zhongyi Li, Jiazhe Yuan, Feng Han, Li Huang, Zhao Wang

“…Oxidative stress, autophagy, and microvascular injury are also potential pathogenic mechanisms. The detection of these symptoms largely depends on laboratory and imaging examinations. …”
Get full text

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice by David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann

“…Abstract The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, currently circulating H5N1 viruses contain multiple mutations within the immunodominant head domain of hemagglutinin (HA) compared to the antigens used in stockpiled vaccines. …”
Get full text

NF-κB Signaling in the Brain of Autistic Subjects by Mazhar Malik, Zujaja Tauqeer, Ashfaq M. Sheikh, Guang Wen, Amenah Nagori, Kun Yang, W. Ted Brown, Xiaohong Li

“…The NF-κB activation is also determined in the brain of BTBR mice, which is a promising animal model for study of pathogenic mechanisms responsible for autism. Our results showed that the level of IKKα kinase, which phosphorylates the inhibitory subunit IκBα, is significantly increased in the cerebellum of autistic subjects. …”
Get full text