Pantoea agglomerans Infections in Children: Report of Two Cases by Shraddha Siwakoti, Rinku Sah, Rupa Singh Rajbhandari, Basudha Khanal

“…Pantoea agglomerans, primarily an environmental and agricultural organism has been reported as both commensal and pathogen of humans. We present two case reports of P. agglomerans infections in children that involved the meninges and bloodstream. …”
Get full text

The infectivity of virus particles from Wolbachia-infected Drosophila by Angelique Asselin, Karyn Johnson

“…Measures of the physical characteristics, infectivity, pathogenicity, and replicative properties of progeny virus particles did not identify any impact of Wolbachia on either DCV or FHV. …”
Get full text

Molecular Study of Acinetobacter baumannii Isolates for Metallo-β-Lactamases and Extended-Spectrum-β-Lactamases Genes in Intensive Care Unit, Mansoura University Hospital, Egypt by Nashwa M. Alkasaby, Maysaa El Sayed Zaki

“…Acinetobacter baumannii (A. baumannii) has been known as a causative pathogen of hospital acquired infections. The aim of this study is to examine the presence of A. baumannii among clinical isolates from intensive care unit (ICU) in Mansoura University Hospital (MUH), its antibiotic resistance pattern, and prevalence of antibiotic resistance genes metallo-β-lactamases (MBLs) and extended-spectrum-β-lactamases (ESBLs) among A. baumannii isolates. …”
Get full text

Mycoketide: A CD1c-Presented Antigen with Important Implications in Mycobacterial Infection by Isamu Matsunaga, Masahiko Sugita

“…Nevertheless, recent advances in our understanding of the CD1c structure as well as the biosynthetic pathway of a CD1c-presented antigen, mannose-1, β-phosphomycoketide, expressed by pathogenic mycobacteria now unravel a new aspect of the group 1 CD1 biology that has not been appreciated in previous studies of CD1a and CD1b molecules.…”
Get full text

Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 by Alhasan Alsalman, Mohammad A. Al-Mterin, Eyad Elkord

“…Some subsets of MDSCs are expanded in the blood of COVID-19 patients; however, there is a controversy whether this expansion has pathogenic or protective effects in COVID-19 patients. …”
Get full text

VIR and Leningrad Quarantine Laboratory: 90 years of cooperation by E. V. Drugova, T. M. Ozerskaya

“…At the same time, the laboratory turned out to be an important research institution, publishing scientific works and methodological guidelines in the field of plant protection.In the course of its activities, the laboratory staff improved the existing methods and developed new ones for phytosanitary control of plant germplasm and its protection against pests, weeds, and pathogenic microorganisms. Manuals, directories, and identification guides written by the laboratory staff still remain the reference books for quarantine and plant protection experts. …”
Get full text

Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance by Alessandra Zanon, Peter P. Pramstaller, Andrew A. Hicks, Irene Pichler

“…Many mutations are clearly pathogenic in some patients while carriers of other mutations either do not develop the disease or show a delayed onset, a phenomenon known as reduced penetrance. …”
Get full text

Treatment of extrasphincter rectal fistulas with bioplastic substance application by A. M. Kuzminov, Sh. T. Minbayev, V. Yu. Korolik, L. P. Orlova, O. Yu. Fomenko, N. A. Polyakova, A. A. Safoyan, S. M. Khermez

“…Surgical treatment of extrasphincter fistulas of rectum by formation of internal fistulous ostium by bioplastic substance «Collost» is pathogenicly proven. Its application allows to achieve permanent clinical effect, to decrease rate of postoperative morbidity, to reduce terms of rehabilitation of the operated patients.…”
Get full text

VIRULENCE OF INFECTIOUS CORYZA CAUSATIVE AGENT ISOLATES by V. A. Evgrafova, A. V. Potekhin

“…Nine out of ten isolates were found pathogenic for poultry. Chicken infected with different isolates of A. paragallinarum demonstrated the same duration of the disease stages. …”
Get full text

Agr-typing of methicillin-susceptible Staphylococcus aureus (MSSA) isolated from non-human primates by V. A. Kalashnikova

“…The present study is devoted to molecular genetic testing of S. aureus isolated from different biological samples taken from monkeys and is based on typing of agr polymorphic locus which acts as a regulator of pathogenic gene expression. As a result of PCR analysis of 301 S. aureus isolates it was established that most of S. aureus belonged to agr IV (55%), and agr I (34%) was the second most group. …”
Get full text

First Case Report of a Late Onset Knee Periprosthetic Joint Infection Caused by Lactococcus garvieae by V.-I. Neagoe, S. Zytoun, H.-J. Neuhaus

“…Lactococcus garvieae is known as a Gram-positive, catalase-negative, and facultatively anaerobic fish pathogen. The association between Lactococcus spp. and human infectious diseases is described as being mainly associated with lumbar osteomyelitis, hepatic abscess, and infective endocarditis. …”
Get full text

Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“… Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavioral disturbances. The pathogenic characteristics encompass the existence of amyloid plaques outside the cells, neurofibrillary tangles inside the cells, neuroinflammation, oxidative stress, and the loss of synapses. …”
Get full text

PPARγ Signaling Mediates the Evolution, Development, Homeostasis, and Repair of the Lung by Virender K. Rehan, John S. Torday

“…By exploiting such deep cell-molecular functional homologies as targets for leveraging lung homeostasis, we have discovered that we can effectively prevent and/or reverse the deleterious effects of these pathogenic agents, demonstrating the utility of evolutionary biology for the prevention and treatment of chronic lung disease. …”
Get full text

Characterization of Erythromycin and Tetracycline Resistance in Lactobacillus fermentum Strains by Elizaveta Anisimova, Dina Yarullina

“…These bacteria may function as vehicles of antibiotic resistance genes, which can be transferred to pathogenic bacteria. Therefore, monitoring and control of transmissible antibiotic resistance determinants in these microorganisms is necessary to approve their safety status. …”
Get full text

Intraspecific variability of Puccinia triticina on hexaploid Triticum species and Aegilops trivialis by E. I. Gultyaeva, E. L. Shaydayuk, I. A. Kazartsev

“…The analysis of pathogen intraspecific differentiation is a necessary stage for the development of a strategy of wheat leaf rust resistance breeding. …”
Get full text

Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…Secondly, models show noncell autonomous signalling within the nervous system, offering the opportunity to develop our understanding of the way pathogenic signalling propagates, resembling Braak’s scheme of spreading pathology in PD. …”
Get full text

Enteropathogenic Bacterial and Intestinal Parasitic Infections among Asymptomatic Food Handlers in Rangsit University Canteens, Central Thailand by Sirima Kitvatanachai, Bajaree Jantrapanukorn, Utsanee Supcharoengoon, Chalirmporn Atasilp

“…The prevalence of enteropathogenic bacteria in stool cultures was 2.5%, and only Aeromonas spp. were detected. The pathogenic protozoa Giardia duodenalis was detected in 1.3% of samples, and nonpathogenic protozoa was found in 11.4%. …”
Get full text

Genotypes and phenotypes of neurofibromatosis type 1 patients in Japan: A Hereditary Tumor Cohort Study by Mashu Futagawa, Tetsuya Okazaki, Eiji Nakata, Chika Fukano, Risa Osumi, Fumino Kato, Yusaku Urakawa, Hideki Yamamoto, Toshifumi Ozaki, Akira Hirasawa

“…We performed sequencing and copy number assays in a clinical laboratory and analyzed the clinical data of 44 patients with suspected NF1. Germline pathogenic variants were detected in 36 patients (81.8%), and 20.7% of the variants were novel. …”
Get full text

A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
Get full text

The Role of Complement System in Septic Shock by Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang

“…This paper also discusses additional complement-related pathogenic mechanisms and intervention strategies for septic shock.…”
Get full text