Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo by Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis

“…In this study, we used Caenorhabditis elegans to screen for E3 ubiquitin ligases regulating the activity of TFEB’s homolog, HLH-30, upon pathogenic infection. We identified WWP-1 as a regulator of HLH-30-dependent immune response controlling HLH-30 stability to mediate host defense in vivo. …”
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Enteric coating of granules containing the probiotic Lactobacillus acidophilus by Pyar Hassan, Peh Kok-Khiang

“…In addition, the enteric coating using Eudragit L30D-55 could protect probiotics from the acidic gastric environment and enhance the bioactivity of probiotics along with replacement of pathogenic microbes in human intestine…”
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Escherichia coli Strains Isolated from the Uteri Horn, Mouth, and Rectum of Bitches Suffering from Pyometra: Virulence Factors, Antimicrobial Susceptibilities, and Clonal Relations... by Juliana M. A. Agostinho, Andressa de Souza, Ruben P. Schocken-Iturrino, Lívia G. Beraldo, Clarissa A. Borges, Fernando A. Ávila, José M. Marin

“…Pyometra is recognized as one of the main causes of disease and death in the bitch, and Escherichia coli is the major pathogen associated with this disease. In this study, 70 E. coli isolates from the uteri horn, mouth, and rectum of bitches suffering from the disease and 43 E. coli isolates from the rectum of clinically healthy bitches were examined for the presence of uropathogenic virulence genes and susceptibility to antimicrobial drugs. …”
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The Impact of Migraine on Posterior Ocular Structures by Süleyman Demircan, Mustafa Ataş, Sevgi Arık Yüksel, Melek D. Ulusoy, İsa Yuvacı, Hasan Basri Arifoğlu, Burhan Başkan, Gökmen Zararsız

“…These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.…”
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The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link? by Balahan Makay, Ozer Makay, Cigdem Yenisey, Gokhan Icoz, Gokhan Ozgen, Erbil Unsal, Mahir Akyildiz, Enis Yetkin

“…Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. …”
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Plant Adaptability to Improved Dredged Sediment by Shoulong Zhang, Rixiong Mo, Haorong Shi, Yuanzhen Li, Yaoyao Zhou, Chenhao Wang, Guanlong Yu

“…The main dominant fungi in the improved soil (IS1) were <i>Tausonia</i>, <i>Trichoderma</i>, and <i>Cystoflobasidium</i>, which promote soil nutrient activation and antagonize pathogenic bacteria, making the environment more conducive to plant growth. …”
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NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

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The influence of biofloc system on Vibrio composition, the growth and the gut microvilli performance of the Pacific white shrimp Penaeus vannamei by Muhamad Gustilatov, Widanarni Widanarni, Julie Ekasari, Pande Gde Sasmita Julyantoro, Diana Elizabeth Waturangi

“…Hep-1b-8 (2.26%) and V. parahaemolyticus (0.80%) known as a pathogenic bacteria dominated the control shrimp gut. …”
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Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionResearch in context by Yanan Li, Ru Xu, Fenglei Quan, Yonghua Wu, Yige Wu, Yongyuan Zhang, Yan Liang, Zhenzhong Zhang, Hua Gao, Ruijie Deng, Kaixiang Zhang, Jinghong Li

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The influence of exercise modality and intensity on ventricular arrhythmia burden and perception of effort in patients with Arrhythmogenic Right Ventricular Cardiomyopathy with pla... by Fernando G. Beltrami, Kyle G. P. J. M. Boyle, Guan Fu, Corinna Brunckhorst, Firat Duru, Christina M. Spengler, Ardan M. Saguner

“…Methods Twenty ARVC patients (8 f/12 m, age 48 ± 15 years, BMI 24 ± 3 kg/m2, resting PVC burden 4 ± 4%) with a heterozygous pathogenic/likely pathogenic plakophilin-2 (PKP-2) variant prospectively performed different exercises while monitored via 12-lead ECG. …”
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Synthesis of silver Nanoparticles@Carbon Dot nanocomposites using Aegle marmelos and Euphorbia hirta: Anti vibriocidal and antioxidant properties by Gali Raman, Sirangu Joseph, D Ramachandran, Phanindra Babu Kasi, Abhinash Marukurti, Alavala Matta Reddy, P Vijaya Nirmala, V S Manikanta, R. Lohitha Kavya, K Sarojani, Anitha Kadimi, Silpa Rani Medapalli, S B Sonia Shankar, G Dinesh Ratna, K Gayathri, P Tirupathi Rao

“…Vibrio parahaemolyticus (Vp) and Vibrio harveyi (Vh) are two pathogenic vibriosis causing agents which are prevalent in commercial aquaculture practices. …”
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The Pathology of T Cells in Systemic Lupus Erythematosus by Anselm Mak, Nien Yee Kow

“…T cells have been recognized to be crucial in the pathogenicity of SLE through their capabilities to communicate with and offer enormous help to B cells for driving autoantibody production. …”
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Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola, Franco Silvestris

“…Herein, we review the major pathogenic links between obesity and susceptibility to cancer.…”
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Hygienic Evaluation of Electrolyzed or Ozonated Water-Washed Apples Stored under Different Temperatures and Relative Humidity Conditions by Jiao Wang, Yuequi Pei, Hyejin Kim, Sung-Yong Hong, Ae-Son Om

“…The presence of spoilage and pathogenic microorganisms is a concern for the safety of apples. …”
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Novel Mutations in the MKKS, BBS7, and ALMS1 Genes in Iranian Children with Clinically Suspected Bardet–Biedl Syndrome by Roghayeh Dehghan, Mahdiyeh Behnam, Mansoor Salehi, Roya Kelishadi

“…All variants were interpreted as pathogenic according to American College of Medical Genetics and Genomics (ACMG) guidelines and confirmed through Sanger sequencing. …”
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A Curious Case of MRSA Bacteremia and Septic Pulmonary Embolism Secondary to Peripheral Venous Catheter by Joshua Twito, Syeda Sahra, Abdullah Jahangir, Neville Mobarakai

“…Peripherally inserted catheters are an important portal for pathogen entry and need periodic site assessment and frequent evaluation of their need for insertion. …”
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Early detection of sepsis using machine learning algorithms by Rasha M. Abd El-Aziz, Alanazi Rayan

“…Sepsis triggers a complicated immune reaction to pathogenic microbes, which frequently leads to septic shock and organ failure. …”
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Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets by Giovanna Morello, Antonio Gianmaria Spampinato, Sebastiano Cavallaro

“…Despite the mechanism underlying motor neuron death is not yet clarified, multiple pathogenic processes have been proposed to account for ALS. …”
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Isolation, Identification, and Resistance Test of Escherichia coli to Antibiotics in Ujung Berung Broiler Poultry by Fatia Nasyna Afifa Kantamaryana, Roostita L Balia, Wendry Setiyadi Putranto

“…Escherichia coli is commensal bacteria in the intestinal of broiler chickens with low virulence. However, mostly pathogenic and cause colibacillosis illness. Inappropriate use of antibiotics in broiler chickens has been widely reported. …”
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Regulatory Role of CD4+ T Cells in Myocarditis by Daria Vdovenko, Urs Eriksson

“…In the presence of tissue damage and innate immune activation, however, activated self-antigen-loaded dendritic cells promote CD4+ effector T cell expansion and myocarditis. So far, a direct pathogenic role has been described for both activated Th17 and Th1 effector CD4+ T cell subsets, though Th1 effector T cell-derived interferon-gamma was shown to limit myocarditis severity and prevent transition to inflammatory dilated cardiomyopathy. …”
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