Werner Syndrome Caused by Homozygous Frameshift Variant c.1578del in WRN by Jovita Patricija Druta, Gunda Petraitytė, Aušra Sasnauskienė, Eglė Preikšaitienė

“…The patient was initially diagnosed with secondary small fiber sensory polyneuropathy and myotonia, but further genetic testing revealed the homozygous pathogenic variant c.1578del in the WRN gene associated with Werner syndrome. …”
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Pyruvate-Enriched Oral Rehydration Solution Improves Glucometabolic Disorders in the Kidneys of Diabetic db/db Mice by Xiao Meng Zhang, Hao Deng, Jin Dong Tong, Yi Zhen Wang, Xu Chao Ning, Xiu Hong Yang, Fang Qiang Zhou, Hui Min Jin

“…Pyruvate is protective from glucometabolic disturbances and kidney dysfunction in various pathogenic insults. Present studies focused on oral pyruvate effects on diabetes status and DN with 0.35% pyruvate in pyruvate-enriched oral rehydration solution (Pyr-ORS) and 1% pyruvate as drinking water for 8 weeks, using the model of diabetic db/db mice. …”
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Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy by Weiran Wang, Xiang Fu, Bolin Gu, Mengxin Hu, Jiaguo Liu

“…Duck hepatitis A virus type 1 (DHAV-1) is a significant pathogen affecting ducklings, capable of causing rapid mortality and adversely impacting the development of the duck industry. …”
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The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications by Ting Ding, Chang Liu, Zhengyu Li

“…Accumulating evidence suggests a possible involvement of commensal and pathogenic fungi in cancer initiation, progression, and treatment responsiveness. …”
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Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice by Takamune Takahashi, Raymond C. Harris

“…These studies clearly defined a critical role of eNOS in DN and developed a robust animal model of this disease, which enables us to study the pathogenic mechanisms of progressive DN. Further, recent studies with this animal model have explored the novel mechanisms by which eNOS deficiency causes advanced DN and provided many new insights into the pathogenesis of DN. …”
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Solitary Pyomyositis of the Left Rhomboideus Muscle Caused by Streptococcus anginosus and Streptococcus intermedius in an Immunocompetent Person by Yasuhiro Tanaka, Kenichi Takaya, Go Yamamoto, Isaku Shinzato, Toshiro Takafuta

“…Primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with Staphylococcus aureus most often isolated as a pathogen. However, pyomyositis caused by anaerobic bacteria is rare in adults. …”
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Enterococcus faecium HDRsEf1 Protects the Intestinal Epithelium and Attenuates ETEC-Induced IL-8 Secretion in Enterocytes by Zhongyuan Tian, Xiaofang Liu, Ran Dai, Yuncai Xiao, Xiliang Wang, Dingren Bi, Deshi Shi

“…In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal pathogen, the mechanism underlying Ef1 protection against an enteropathogen was investigated. …”
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The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis by Xiao-Qing Wei, Helen Rogers, Michael A. O. Lewis, David W. Williams

“…Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. …”
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The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells by Jieqiong Qu, Michelle Schinkel, Lisa Chiggiato, Samara Rosendo Machado, Gijs J. Overheul, Pascal Miesen, Ronald P. van Rij

“…Abstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. …”
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Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation by Xihang Chen, Yunfan He, Feng Lu

“…Impairment of this process has been implicated in various diseases, in the pathogenic response to bacterial and viral infections, and in aging. …”
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Seroprevalence and Risk Factors of Chlamydia abortus Infection in Tibetan Sheep in Gansu Province, Northwest China by Si-Yuan Qin, Ming-Yang Yin, Wei Cong, Dong-Hui Zhou, Xiao-Xuan Zhang, Quan Zhao, Xing-Quan Zhu, Ji-Zhang Zhou, Ai-Dong Qian

“…Chlamydia abortus, an important pathogen in a variety of animals, is associated with abortion in sheep. …”
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Ischemic Changes in the Mucous Membrane of the Transverse Colon as a Complication of Acute Pancreatitis by D. A. Semenov, S. G. Shapovalyants, D. E. Seleznev, O. I. Yudin, S. V. Korolev, N. A. Gracheva, L. M. Mikhaleva, K. S. Paramonenko

“…Negative results of analysis for toxins A and B of Clostridioides difficile and pathogenic intestinal flora were obtained. By the means of intensive care, it was possible to achieve complete stabilization of the patient's condition, normalization of laboratory blood parameters and relief of ischemic processes in the colon wall.Conclusion. …”
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Modeling BK Virus Infection in Renal Transplant Recipients by Nicholas Myers, Dana Droz, Bruce W. Rogers, Hien Tran, Kevin B. Flores, Cliburn Chan, Stuart J. Knechtle, Annette M. Jackson, Xunrong Luo, Eileen T. Chambers, Janice M. McCarthy

“…However, these same medications leave them susceptible to opportunistic infections. One pathogen of particular concern is human polyomavirus 1, also known as BK virus (BKPyV). …”
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Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide by Kumju Youn, Chi-Tang Ho, Mira Jun

“…Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. AD has a complex pathogenic mechanism, and a single-target approach for anti-AD strategy is thus full of challenges. …”
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Ischemic heart disease and reflux-esophagitis: complexities of the differential diagnosis and treatment. by Yu. N. Belenkov, Ye. V. Privalova, A. O. Yusupova, M. V. Kozhevnikova

“…Application of prokinetics in complex treatment of RE at IHD patients is pathogenically proven. Combination of diseases requires long treatment, dictates necessity of choice of the safe agent, having no negative effect on the course of IHD.Conclusion. …”
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Simultaneous Detection and Differentiation of Highly Virulent and Classical Chinese-Type Isolation of PRRSV by Real-Time RT-PCR by Shuqi Xiao, Yaosheng Chen, Liangliang Wang, Jintao Gao, Delin Mo, Zuyong He, Xiaohong Liu

“…The PRRS epidemic situation in China has been very complicated since the unprecedented large-scale highly pathogenic PRRS (HP-PRRS) outbreaks in 2006. And now the HP-PRRS virus (HP-PRRSV) and classical North American type PRRSV strains have coexisted in China. …”
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MRSA COLONITATION DETECTION IN OBJECT NEAR PATIENTS IN BURN UNIT RSUD DR. SOETOMO - INDONESIA by Manik Retno Wahyunitisari, Melisa Indah Mustikasari, Lynda Hariani

“…Methicillin-resistant Staphylococcus aureus (MRSA) as the prototype of a nosocomial pathogen is usually transmitted through contact from the surfaces of the object to the non-intact skin. …”
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Progress in Oral Vaccination against Tuberculosis in Its Main Wildlife Reservoir in Iberia, the Eurasian Wild Boar by Beatriz Beltrán-Beck, Cristina Ballesteros, Joaquín Vicente, José de la Fuente, Christian Gortázar

“…An oral vaccination with a new heat-killed M. bovis vaccine conferred a protection similar to BCG. The study of host-pathogen interactions identified biomarkers of resistance/susceptibility to tuberculosis in wild boar such as complement component 3 (C3) and methylmalonyl coenzyme A mutase (MUT) that were used for vaccine development. …”
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Health and Safety Considerations of Fermented Sausages by Askild Holck, Lars Axelsson, Anette McLeod, Tone Mari Rode, Even Heir

“…In addition, we review the food pathogenic microorganisms relevant for fermented sausages (Escherichia coli, Salmonella enterica, Staphylococcus aureus, Listeria monocytogenes, Clostridium botulinum, and Toxoplasma gondii) and processing and postprocessing strategies to inhibit their growth and reduce their presence in the products.…”
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Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan by Chi-Neu Tsai, Yu-Chung Chang, Hsun-Ching Chao, Yi-Hsiang Hsu, Yuan-Hung Wang, Shih-Yen Chen

“…Norovirus (NoV) has been an emerging pathogen of enteric infections in the post-rotavirus vaccine era. …”
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