The large-scale whole-genome sequencing era expedited medical discovery and clinical translation by Qingxin Yang, Shuhan Duan, Yuguo Huang, Chao Liu, Mengge Wang, Guanglin He

“…This imbalance has hampered health equity and precision medicine, resulting in limited transferability of polygenic risk scores to underrepresented populations and misinterpretations of the pathogenicity of genomic variants. Recent advancements in sequencing technology have enabled the implementation of large-scale, high-quality, diverse, multi-omics, and engineered genomic projects, including the All of Us Research Program and the Trans-Omics for Precision Medicine Program. …”
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Identification of bapA in Strains of Salmonella enterica subsp. enterica Isolated from Wild Animals Kept in Captivity in Sinaloa, Mexico by Gabriela Silva-Hidalgo, Martin López-Valenzuela, Nora Cárcamo-Aréchiga, Silvia Cota-Guajardo, Mayra López-Salazar, Edith Montiel-Vázquez

“…Biofilm formation is associated with the ability to persist in different environments, which contributes to the pathogenicity of several species. We analyzed the presence of bapA in 83 strains belonging to 17 serovars of Salmonella enterica subsp. enterica from wildlife in captivity at Culiacan’s Zoo and Mazatlán’s Aquarium. …”
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Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…We use the model topredict disease progression scenarios, including primary, latency or clearance.Model analysis shows that occurrence of active disease is much attributedto the Mtb pathogen ability to persist outside the intracellular environmentand that high levels of CTLs result in latent TB, while low levels of CTLsresult in active TB. …”
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Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report by Lulu Wang, Yahui Feng, Sisi Wang, Leyao Shi, Yong Ren, Zhiya Yang, Dongmei Shi

“…The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…ABSTRACT The current situation with H5N1 highly pathogenic avian influenza virus (HPAI) is causing a worldwide concern due to multiple outbreaks in wild birds, poultry, and mammals. …”
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Deep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues by Saúl Rojas-Sánchez, Nikolay G. Kolev, Christian Tschudi

“…Abstract To regain infectivity, Trypanosoma brucei, the pathogen causing Human and Animal African trypanosomiasis, undergoes a complex developmental program within the tsetse fly known as metacyclogenesis. …”
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Prevalence of Brucellosis among Women Presenting with Abortion/Stillbirth in Huye, Rwanda by Nadine Rujeni, Léonidas Mbanzamihigo

“…More mechanistic studies will also demonstrate the pathogenicity of Brucella in human placentas.…”
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The growing challenge of autism spectrum disorder: a comprehensive review of etiology, diagnosis, and therapy in children by Chunyuan Wang, Hong Wang

“…Finally, this paper summarizes the current status of autism research, looks forward to future research directions, and calls for more research to explore the pathogenic mechanisms, diagnostic basis, and therapeutic methods of autism.…”
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The Management of Inflatable Penile Prosthesis Erosion and Infection following Iatrogenic Aspiration by Ali Baydoun, Alexander Benben, Matthew Skalak, Jordan Bilbrew, Mazen Abdelhady

“…Intraoperative cultures identified Escherichia cloacae as the causative pathogen. This case highlights the importance of thorough chart review to identify patients with IPPs before aspiration procedures and emphasizes the need for healthcare provider education regarding potential complications in this patient population. …”
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Iron depletion in “metabolic fatty liver syndromes”: a strong biological rationale with disappointing liver outcomes by Amedeo Lonardo

“…Iron plays a key role in many of the key pathogenic steps concurring in the development and progression of MFLS, notably including genetics, intestinal dysbiosis, adipositis, insulin resistance, metaflammation, oxidative stress and ferroptosis, endoplasmic reticulum stress, and hepatic fibrosis. …”
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Preparation of Copper Nanoparticles/Diatomite Nanocomposite for Improvement in Water Quality of Fishponds by Truong Thi Hanh, Nguyen Thuy Lan Chi, Nguyen Ngoc Duy

“…Antibacterial activity of CuNPs/DA nanocomposite against pathogenous bacteria for catfish such as Aeromonas hydrophila and Edwardsiella ictaluri was estimated.…”
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Preventing Foodborne Illness: E. coli O157:H7 by Keith R. Schneider, Renée Goodrich Schneider, Ploy Kurdmongkoltham, Bruna Bertoldi

“… This seven-page fact sheet discusses the common foodborne pathogen E. coli O157:H7, especially as it concerns food handlers, processors and retailers. …”
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Streptococcus intermedius Bacteremia and Liver Abscess following a Routine Dental Cleaning by Lachara V. Livingston, Elimarys Perez-Colon

“…In fact, the development of liver abscesses secondary to dental procedures is very rare in general, and there are only a few case reports in the literature describing this in relation to any pathogen. We present a rare case of S. intermedius bacteremia and liver abscess following a dental cleaning. …”
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Electroacupuncture Stimulation Suppresses Postoperative Inflammatory Response and Hippocampal Neuronal Injury by Xiang-feng Wang, Qin Lin, Guan-hui Wang, Gen-ming Zhan, Wei Liu, Zhi-wei Lin

“…These findings indicated the POCD was the synergistic outcome of anaesthesia and surgical stimulation but with different pathogenic mechanism. The surgery with mental tri-needles (surgery+MTN) group outperformed the surgery group in terms of cognitive function performance. …”
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A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials. by Maonezi Abas Hamisi, Nur Ain Mohd Asri, Aini Syahida Mat Yassim, Rapeah Suppian

“…<h4>Conclusion</h4>Factors such as population characteristics, pathogen genetic diversity, vaccine nature, strategy, and formulation were associated with slow progress of the malaria and TB vaccine candidates in sub-Saharan African clinical trials.…”
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Microevolution during Chronic Infection May Lead T. asahii to Coexist with the Host by Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang

“…Compared with the primary T. asahii strain, the microevolved strain induced much lower expression of TNF-α by mice bone marrow-derived DC and had a much superior survival rate, a total of 2212 significantly differentially expressed genes were identified in the microevolved strain, and functional analysis showed significance in the downregulated transcription and metabolic process, especially the valine, leucine, and isoleucine degradation pathways, which were associated with pathogenicity and virulence; hence, the results were highly consistent with the decreased immunogenicity and virulence of the microevolved strain. …”
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Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance? by Gloria Lopez-Castejon, Mariola J. Edelmann

“…It occurs when the immune system recognizes Pathogen-Associated Molecular Patterns (PAMPs) or Damage-Associated Molecular Pattern (DAMPs) through the activation of Pattern Recognition Receptors. …”
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Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue by Sofia Dias, Sílvia Paredes, Laura Ribeiro

“…Obesity and dyslipidemia are main features of metabolic syndrome, and both can present with adipose tissue dysfunction, involved in the pathogenic mechanisms underlying this syndrome. We revised the effects, and underlying mechanisms, of the current approved drugs for dyslipidemia and obesity (fibrates, statins, niacin, resins, ezetimibe, and orlistat; sibutramine; and diethylpropion, phentermine/topiramate, bupropion and naltrexone, and liraglutide) on adipose tissue. …”
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Green-Synthesized Sm3+-Doped ZnO Nanoparticles for Multifunctional Applications by Lavanya R., Ramakrishnappa T., Girish K. M., Suresh Kumar K., Basavaraju N., Shilpa B. M.

“…The antibacterial activity was performed against two pathogenic strains, i.e., Escherichia coli and Streptococcus aureus. …”
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Cepacia Syndrome in a Non-Cystic Fibrosis Patient by Naomi Hauser, Jose Orsini

“…The potential for this pathogen to infect non-cystic fibrosis patients is limited and its epidemiology is poorly understood. …”
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