The Role of Cell Surface Architecture of Lactobacilli in Host-Microbe Interactions in the Gastrointestinal Tract by Ranjita Sengupta, Eric Altermann, Rachel C. Anderson, Warren C. McNabb, Paul J. Moughan, Nicole C. Roy

“…Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. …”
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Survey of Traveler’s Diarrhea: Epidemiology and Testing Reveal the Source by Zhenguo Gao, Muti Mahe, Shabiremu Tuohetamu, Fang Li, Jian Zhang, Yidan Xia, Xiaona Sun, Abuzhalihan Naerkezi, Ruifang Huang, Hongbin Liu, Daxin Ni, Rong Zhang

“…Real-time fluorescent quantitative PCR, bacterial culture, and serological identification methods were used for pathogen detection and identification. Result. There were 7 cases of illness, and the attack rate was 46.67%. …”
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Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes by Nathan M Shugarts Devanapally, Aishwarya Sathya, Andrew L Yi, Winnie M Chan, Julia A Marre, Antony M Jose

“…RNAs in circulation carry sequence-specific regulatory information between cells in plant, animal, and host-pathogen systems. Such RNA can cross generational boundaries, as evidenced by somatic double-stranded RNA (dsRNA) in the nematode Caenorhabditis elegans silencing genes of matching sequence in progeny. …”
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Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells by Ryosuke Fukuda, Shiori Beppu, Daichi Hinata, Yuka Kamada, Tsukasa Okiyoneda

“…Here we report that pathogen-associated molecular patterns (PAMPs) disrupt the EPHA2-EFNA1 trans-binding in airway epithelial cells (AECs). …”
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Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways by Lisha Ye, Katarina Stoklund Dittlau, Adria Sicart, Rekin'’s Janky, Philip Van Damme, Ludo Van Den Bosch

“…The exact underlying pathogenic mechanism(s) remain elusive. This is particularly the case for sporadic ALS (sALS), representing 90 % of cases, as modelling a sporadic disease is extremely difficult. …”
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Biofabrication of brain-like living tissue: structure to intelligence by Ling Wang, Sen Wang, Yingjie Liu, Bowen Zhang, Zhaoyu Pan, Luge Bai, Siqi Yao, Chenrui Zhang, Huangfan Xie, Jiankang He, Dichen Li

“…Brain diseases are among the leading threats to human life, yet our understanding of their pathogenic mechanisms and drug development remains limited, largely due to the lack of accurate brain-like tissue models that replicate its complex structure and functions. …”
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A comprehensive method on black-legged tick larvae and nymph feeding on mice to study Lyme disease transmission and acquisition by Aaron Scholl, Bingjie Li, John Dennis, Sandip De

“…Human-driven changes in climate and ecosystems have expanded the habitat of pathogen-carrying ticks, facilitating the spread of these infections. …”
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Recent advances in the science of human milk oligosaccharides by Tadasu Urashima, Katsumi Ajisaka, Tetsuro Ujihara, Eri Nakazaki

“…Approximately 200 varieties of HMOs have been characterized.Although HMOs are not utilized as an energy source by infants, they have important protective functions, including pathogenic bacteria and viral infection inhibitors and immune modulators, among other functions, and HMOs stimulate brain-nerve development. …”
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Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome by Sz-Jiun Shiu, Ting-Ting Li, Bor-Jen Lee, Pin-Kuei Fu, Chen-Yu Wang, Sz-Iuan Shiu

“…Acute respiratory distress syndrome (ARDS) and hemophagocytic lymphohistiocytosis (HLH) are accompanied with poor outcome and high mortality when miliary tuberculosis is a causative pathogen for both of them. A patient complicated with ARDS and HLH is unusual in critical care, and few case reports are present in PudMed. …”
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Mathematical modeling of Glassy-winged sharpshooter population by Jeong-Mi Yoon, Volodymyr Hrynkiv, Lisa Morano, Anh Tuan Nguyen, Sara Wilder, Forrest Mitchell

“…Pierce's disease (PD) is a fatal disease of grapevines whichresults from an infection by the plant pathogen Xyllelafastidiosa. This bacterium grows in the xylem (water-conducting)vessels of the plant blocking movement of water. …”
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Research progress in prevention and nursing of shoulder-hand syndrome in stroke patients (中风患者肩手综合征的预防与护理进展) by GUO Linyu (郭琳宇), CHEN Ying (陈迎)

“…This article describes the clinical manifestations and pathogenic factors of shoulder-hand syndrome, and summarizes its preventive measures and clinical nursing measures in order to provide new ideas for clinical nursing. …”
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PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma by Yuehua Li, Yu Liu, Jingjing Ma, Yuqi Yang, Qiao Yue, Guannan Zhu, Weinan Guo, Tianwen Gao, Qiong Shi, Chunying Li

“…Abstract Besides the important pathogenic mechanisms of melanoma, including BRAF-driven and immunosuppressive microenvironment, genomic instability and abnormal DNA double-strand breaks (DSB) repair are significant driving forces for its occurrence and development. …”
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A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion by Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang

“…Hepatitis B virus (HBV) represents one of the major pathogenic factor that leads to chronic liver diseases and the development of hepatocellular carcinoma (HCC). …”
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Organic disinfectant using coconut shell liquid smoke in the chicken slaughterhouse wastewater treatment plant by Cortheo Donny Yuslan, Budiyono, Sutaryo

“…Wastewater treatment in Chicken Slaughterhouse is absolutely necessary because it has a very positive impact on environmental preservation and helps remove pathogenic organisms in wastewater before being discharged into the environment. …”
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Interferon-gamma rescues dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching by Amit Adlakha, Thomas J. Williams, Xinxin Shou, Anna K. Reed, Boris Lenhard, Darius Armstrong-James

“…We find that interferon gamma activates alternative transcriptional pathways to calcineurin-NFAT for the augmentation of pathogen handling. Histone modification ChIP-Seq analysis revealed dominant control by an interferon gamma induced regulatory switch from STAT3 to STAT1 transcription factor binding underpinning these observations. …”
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What’s in a name? Memory NK cells for cancer immunotherapy by William J Murphy, Robert J Canter, Sean J Judge, Megan C Purl

“…The discovery that natural killer (NK) cells can retain features of “memory” from previous stimulation and pathogen exposure was a landmark advance highlighting one of many ways in which NK cells of the innate immune system resemble T cells of the adaptive immune system. …”
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Bacillary Angiomatosis in an HIV-positive Man with Multiple Risk Factors: A Clinical and Epidemiological Puzzle by Farrah J Mateen, Jill C Newstead, Karen L McClean

“…Speciation by 16s ribosomal RNA analysis confirmed B quintana as the pathogen. Because the patient presented with skin lesions, the diagnosis was straightforward; however, skin lesions are nondiagnostic in some cases. …”
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New Hosts of Simplicimonas similis and Trichomitus batrachorum Identified by 18S Ribosomal RNA Gene Sequences by Kris Genelyn B. Dimasuay, Orlie John Y. Lavilla, Windell L. Rivera

“…The generated phylogenetic tree yielded three distinct groups mostly with relatively moderate to high bootstrap support and in agreement with the most recent classification. Pathogenic potential of the trichomonads in these hosts still needs further investigation.…”
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Ultrathin metal-organic framework nanosheets (Cu-TCPP)-based isothermal nucleic acid amplification for food allergen detection by Jiale Gao, Xiaodong Sun, Yongxin Liu, Bing Niu, Qin Chen, Xueen Fang

“…Apart from food allergens, this novel assay can be widely used in other areas, such as pathogen detection, tumor nucleic acid detection and so on.…”
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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

“…When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. …”
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