In vivo regulation of the monocyte phenotype by Mycobacterium marinum and the ESX-1 type VII secretion system by Kristina Munke, Line Wulff, Julia Lienard, Fredric Carlsson, William W. Agace

“…Abstract Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. …”
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A note on dynamics of an age-of-infection cholera model by Jinliang Wang, Ran Zhang, Toshikazu Kuniya

“…The model is incorporated with both the infection age of infectious individuals and biological age of pathogen in the environment. The basic reproduction number is proved to be a sharp threshold determining whether or not cholera dies out. …”
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Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses by Buyuan He, James T. Tran, David Jesse Sanchez

“…However, as additional studies into the function of Type I Interferons progressed, it was also seen that pathogenic viruses have coevolved to encode potent mechanisms allowing them to evade or suppress the impact of Type I Interferons on their replication. …”
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Genomic analysis of antimicrobial resistant Escherichia coli isolated from manure and manured agricultural grasslands by C. Tyrrell, C. M. Burgess, F. P. Brennan, D. Münzenmaier, D. Drissner, R. J. Leigh, F. Walsh

“…The environment can harbour Escherichia coli that are pathogenic or commensal. Escherichia coli is used as an indicator of environmental faecal contamination. …”
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Antifungal Resistance and New Strategies to Control Fungal Infections by Patrick Vandeputte, Selene Ferrari, Alix T. Coste

“…Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.…”
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The Association Between Human Cytomegalovirus and Salivary Gland Cancer: An Analytical Study and Literature Review by Hagir Abd Rahman Mahmoud, Ahmed Mohamed Suleiman, Elwaleed Mohamed Elamin, Sawsan Abdel Rahim Mohammed

“… Background: Human cytomegalovirus (HCMV) is a widespread human pathogen that triggers varying clinical symptoms depending on the host’s age and immune status. …”
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A Case of Cardiac Arrest during C1 Laminectomy for Irreducible Atlantoaxial Subluxation by Yosuke Shibao, Masao Koda, Keita Nakayama, Tomoyuki Asada, Kosuke Sato, Mamoru Kono, Fumihiko Eto, Kentaro Mataki, Hiroshi Kumagai, Katsuya Nagashima, Kousei Miura, Hiroshi Noguchi, Hiroshi Takahashi, Toru Funayama, Tetsuya Abe, Masashi Yamazaki

“…There was no postoperative worsening of neurological symptoms, and the improvement of sensory and motor palsy was favorable. The pathogenic mechanism was presumed to be trigeminocardiac reflex. …”
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Immunomagnetic Separation of Salmonella Typhimurium Based on Microfluidic Chip by JIN Yan, WANG Jingyi, CHENG Jianing, YU Lemin, ZHANG Bichen, ZHANG Yibo, XU Tongyu

“…This highly integrated immunomagnetic separation microfluidic system can enrich target bacteria from complex food matrices rapidly and accurately, thus providing an effective solution for the rapid detection of foodborne pathogenic bacteria, which is of great significance in addressing public health problems caused by foodborne diseases.…”
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Cotton (Gossypium hirsutum) Cultivars Exhibiting Tolerance to the Reniform Nematode (Rotylenchulus reniformis) by Julie A. Blessitt, Salliana R. Stetina, Ted P. Wallace, Peggy T. Smith, Gabriel L. Sciumbato

“…Though they will not suppress the reniform nematode population, these cultivars can help reduce economic losses attributed to this pathogen in the Midsouth region of the USA.…”
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Juvenile Hemochromatosis due to a Homozygous Variant in the HJV Gene by María-Belén Moreno-Risco, Manuel Méndez, María-Isabel Moreno-Carralero, Ana-María López-Moreno, José-Manuel Vagace-Valero, María-José Morán-Jiménez

“…Juvenile hemochromatosis type 2a and 2b is an autosomal recessive disease caused by pathogenic variants in HJV and HAMP genes, respectively. …”
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Classification of distinct tendinopathy subtypes for precision therapeutics by Chenqi Tang, Zetao Wang, Yuanhao Xie, Yang Fei, Junchao Luo, Canlong Wang, Yue Ying, Peiwen He, Ruojing Yan, Yangwu Chen, Jiayun Huang, Yiwen Xu, Zicheng Wang, Boon Chin Heng, Hengzhi Liu, Jianyou Li, Zi Yin, Haobo Wu, Weishan Chen, Hongwei Ouyang, Xiao Chen, Weiliang Shen

“…Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features. …”
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Strategies for the Development of Bioprotective Cultures in Food Preservation by Luana Virgínia Souza, Evandro Martins, Isabella Maria Fernandes Botelho Moreira, Antônio Fernandes de Carvalho

“…In this context, the lactic acid bacteria (LAB) have been extensively prospected as a bioprotective culture, as they have a long history in food production and their antimicrobial activity against spoilage and pathogenic microorganisms is well established. However, to make LAB cultures available in the market is not that easy, the strains should be characterized phenotypically and genotypically, and studies of safety and technological application are necessary to validate their bioprotection performance. …”
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Compound Heterozygous Mutations in TMC1 and MYO15A Are Associated with Autosomal Recessive Nonsyndromic Hearing Loss in Two Chinese Han Families by Pengcheng Xu, Jun Xu, Hu Peng, Tao Yang

“…The two novel mutations identified in this study, p.M413T in TMC1 and p.R1407T in MYO15A, are classified as likely pathogenic according to the guidelines of ACMG. Our study expanded the mutation spectrums of TMC1 and MYO15A and illustrated that genotype-phenotype correlation in combination with next-generation sequencing may improve the accuracy for genetic diagnosis of deafness.…”
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Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis by Masahito Ebina, Hiroyuki Taniguchi, Taku Miyasho, Shingo Yamada, Naoko Shibata, Hiromitsu Ohta, Shu Hisata, Shinya Ohkouchi, Tsutomu Tamada, Hidekazu Nishimura, Akitoshi Ishizaka, Ikuro Maruyama, Yoshinori Okada, Kondo Takashi, Toshihiro Nukiwa

“…These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF.…”
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Neglected Case of Human Balantidiasis: Presumed as Antibiotic-Associated Diarrhoea by Sreska Shrestha, Priyatam Khadka

“…Balantidiasis, due to its rare human incidence and nonspecific clinical presentations often neglected from the diagnosis considerations; however, a potent pathogen. Herein, we report a case of neglected balantidiasis presumed as antibiotic-associated diarrhoea. …”
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Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome by Kishan Kumar Nyati, Kashi Nath Prasad

“…Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system, mostly triggered by an aberrant immune response to an infectious pathogen. Although several infections have been implicated in the pathogenesis of GBS, not all such infected individuals develop this disease. …”
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Anaerobic Digesters for Manure Management at Livestock Operations by Rishi Prasad, George Hochmuth, Ann C. Wilkie

“…The stabilization process reduces the organic matter and water contents, unpleasant odors, concentrations of pathogenic microorganisms, and weed seeds. Anaerobic digestion (AD), which is the topic of this fact sheet, also results in the production of renewable energy in the form of methane-rich biogas. …”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. …”
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Data Mining Classification Techniques for Diabetes Prediction by Hindreen Rashid Abdulqadir, Adnan Mohsin Abdulazeez, Dilovan Assad Zebari

“…This study proposed a system biology approach to the pathogenic process to identify essential biomarkers as drug targets. …”
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Persistent and extended COVID, post-COVID-19. New reflections in 2024 by Alfredo Darío Espinosa Brito

“…Although most therapeutic approaches in patients with persistent COVID are symptomatic and supportive, based on the clinical expertise of the professionals who care for the patients, recent advances in the description of clinical phenotypes, further research into molecular research and the search to identify specific biomarkers could provide new evidence on their pathogenic mechanisms and more personalized approaches to the clinical care of these patients, who constitute a real health and occupational problem in the world today. …”
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