The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies by Hessam Yaghmaei, Amirhossein Bahanesteh, Masood Soltanipur, Sobhan Takaloo, Mahdi Rezaei, Seyed Davar Siadat

“…Therefore, the study of the effect of dysbiosis on the pathogenicity of NAFLD is important. European clinical guidelines state that the best advice for people with NAFLD is to lose weight and improve their lifestyle, but only 40% of people can achieve this goal. …”
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Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases by Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang

“…Abstract Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding of cellular prion proteins into pathogenic forms. The development of these diseases is intricately linked to oxidative stress and mitochondrial dysfunction. …”
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Antibiotic Susceptibility Patterns of Bacterial Isolates from Pus Samples in a Tertiary Care Hospital of Punjab, India by Rugira Trojan, Lovely Razdan, Nasib Singh

“…E. coli was the most prevalent pathogen (51.2%) followed by Staphylococcus aureus (21%), Klebsiella pneumoniae (11.6%), Pseudomonas aeruginosa (5.8%), Citrobacter spp. (3.5%), Acinetobacter baumannii (2.3%), Proteus mirabilis (2.3%), and Streptococcus spp. (2.3%). …”
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The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins by Minkiewicz Piotr, Sokolowska Jolanta, Darewicz Malgorzata

“…The rare pentapeptide with the DEERM sequence occurs in proteins not sharing homology with tropomyosins. Pathogenic microorganisms are the most abundant category of organisms synthesizing such proteins.…”
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Geographic variation in abundance and diversity of Acinetobacter baumannii Vieuvirus bacteriophages by Dafne Arellano-Maciel, Juan Manuel Hurtado-Ramírez, Laura Carolina Camelo-Valera, Santiago Castillo-Ramírez, Alejandro Reyes, Gamaliel López-Leal

“…IntroductionProphages play a crucial role in the genomic diversity of Acinetobacter baumannii, contributing to its pathogenicity and adaptation.MethodsIn this study, we induced and sequenced seven prophages from five isolates of A. baumannii. …”
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Porphyric encephalopathy in a 15-year-old girl: A case report by Saihari S Dukkipati, Jordan Terschluse, Drew Thodeson, Angela Beavers, Melissa Muff-Luett, Claire Ives, Sookyong Koh

“…A hydroxymethylbilane synthase (porphobilinogen deaminase) pathogenic variant was found in porphyria gene panel confirming the diagnosis of acute intermittent porphyria. …”
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Disorder of intracellular cobalamin metabolism: Importance of rapid diagnostic illustrated by a case report of early-onset methylmalonic aciduria and homocystinuria, cobalamin C ty... by Etienne Mondesert, Bastien Baud, Agathe Roubertie, Jean-François Benoist, Pierre-Edouard Grillet, Jean-Paul Cristol, Marie Céline Francois-Heude, Manuel Schiff, Stéphanie Badiou

“…Diagnosis was later confirmed by genetic analysis which identified two pathogenic variants on the MMACHC gene: c.271dupA (p.Arg91lysfs∗14) paternal allele and c.388T > C (p.Tyr130His) maternal allele. …”
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Gas Gangrene in Orthopaedic Patients by Zhimin Ying, Min Zhang, Shigui Yan, Zhong Zhu

“…Several factors, if available, were analyzed for each case: age, cause of injury, fracture location, pathogen, and outcome. Based on our case report and the literature review, emergency clinicians should be aware of this severe and potentially fatal infectious disease and should not delay treatment or prompt orthopedic surgery consultation.…”
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Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots by Dos Santos Delair Silveira, Oberger Júlia Vieira, Niero Rivaldo, Wagner Theodoro, Delle Monache Franco, Cruz Alexandre Bella, Martin-Quintal Zhelmy, Cechinel Filho Valdir

“…The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. …”
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Dysphoric spectrum of emotional disorders at irritable bowel syndrome by M. A. Morozova, G. Ye. Rupchev, A. A. Alekseyev, A. G. Beniashvili, M. V. Mayevskaya, Ye. A. Poluektova, O. Z. Okhlobystina, V. T. Ivashkin

“…Somatic manifestations of IBS are associated to dysphoric experience indicating their potential pathogenic value. Imbalance between the scope of data on emotional disorders at IBS and the number of studies devoted to psychopharmacotherapy efficacy assessment at emotional disorders was revealed. …”
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Attempts to identify the molecular cause of autoinflammatory recurrent fever by Oksana Boyarchuk, Diana Savkiv

“…We present the molecular diagnosis results of 12 children with recurrent fever, analyzing the correlation between molecular findings and clinical symptoms. No pathogenic variants confirming autoinflammatory disease were found. …”
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The ubiquitin ligase Pellino1 targets STAT3 to regulate macrophage-mediated inflammation and tumor development by Soeun Hwang, Junhee Park, Seo-Young Koo, Si-Yeon Lee, Yunju Jo, Dongryeol Ryu, Heounjeong Go, Chang-Woo Lee

“…Mechanistically, Pellino1 targets STAT3 for lysine 63-mediated ubiquitination, resulting in pathogenic activation of STAT3 signaling. Taken together, our findings reveal a macrophage-specific ubiquitination signaling axis in colitis and CAC development and suggest that Pellino1 is a potential candidate for treating chronic inflammation and inflammation-related cancer.…”
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Probiotics, metabolism and the functional condition of cardio-vascular system by Ye. A. Kashukh, V. T. Ivashkin

“…Along with traditional concepts on the risk factors of atherosclerosis and cardio-vascular diseases development one should take into account data on the new pathogenic mechanisms for these diseases. According to recent studies human gastrointestinal microbiome may increase cardiovascular risk due to bacterial production of proinflammatory proteins that both promote development of atherosclerosis and directly affect the heart and vessels. …”
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Current status and potential of bacteriocin-producing lactic acid bacteria applied in the food industry by Qingping Liang, Wei Zhou, Siyuan Peng, Ziyu Liang, Zhemin Liu, Changliang Zhu, Haijin Mou

“…Bacteriocins produced by LAB have attracted the attentions for application in the food industry as natural food bio-preservatives because of their antimicrobial activity against the food spoilage and pathogenic bacteria. With the increasing demands of consumers for more healthier food and investigations on natural food preservatives, the bioactivity of bacteriocins allows them to give the application values to the bacteriocin-producing LAB. …”
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Effectiveness of the California Mastitis Test (CMT), Reductase Test, and Alcohol Test for Dairy Cows Subclinical Mastitis Detection by Eriza Rosalina Rochmah, Dadik Raharjo, Sri Hidanah, Mustofa Helmi Effendi, Adiana Mutamsari Witaningrum, Sunaryo Hadi Warsito

“…Mastitis is an inflammation of the mammary glands caused by pathogenic bacteria Mastitis divided into 2 types, clinical mastitis which has symptoms of swelling and changes in the shape of the mammary gland, while subclinical mastitis does not indicate clear symptoms. …”
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases by Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi, Anwar Abdelnaser

“…In addition, gut microbial metabolites play crucial roles in infectious disease susceptibility and resilience, mediating immune pathways that impact pathogen resistance. By consolidating recent insights into the gut microbiota’s role in shaping disease and health, this review underscores the therapeutic potential of targeting microbiome-derived metabolites for treating GI cancers and infectious diseases and calls for further research into microbiome-based interventions.…”
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How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). …”
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Cardiopulmonary bypass associated acute kidney injury: better understanding and better prevention by Xutao Yang, Li Zhu, Hong Pan, Yi Yang

“…Finally, we explore current interventions aimed at preventing and attenuating renal impairment related to CPB, and presenting these measures from three perspectives: (1) avoiding CPB to eliminate the fundamental impact on renal function; (2) optimizing CPB by adjusting equipment parameters, optimizing surgical procedures, or using improved materials to mitigate kidney damage; (3) employing pharmacological or interventional measures targeting pathogenic factors.…”
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Peripheral proteinopathy in neurodegenerative diseases by Bin Xu, Xia Lei, Ying Yang, Jiayi Yu, Jun Chen, Zhi Xu, Keqiang Ye, Jing Zhang

“…This review summarizes the distribution, transportation pathways, and pathogenic mechanisms of several neurodegenerative disease-related pathological proteins in the periphery, proposing that targeting these peripheral pathological proteins could be a promising strategy for preventing and managing neurological diseases.…”
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Empedobacter brevis Bacteremia in a Patient Infected with HIV: Case Report and Review of Literature by Syed Bokhari, Naeem Abbas, Manisha Singh, Richard B. Cindrich, Cosmina Zeana

“…In conclusion, E. brevis is an emerging pathogen that can cause serious health care associated infections.…”
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