West Nile Virus Infection in Pregnancy by Robert D. Stewart, Stefanie N. Bryant, Jeanne S. Sheffield

“…A recent outbreak of West Nile virus has allowed for observations as to the clinical course of this emerging pathogen during pregnancy. We present three cases of West Nile virus infection during pregnancy. …”
Get full text

Vital Pulp Therapy—Current Progress of Dental Pulp Regeneration and Revascularization by Weibo Zhang, Pamela C. Yelick

“…Pulp vitality is extremely important for the tooth viability, since it provides nutrition and acts as biosensor to detect pathogenic stimuli. In the dental clinic, most dental pulp infections are irreversible due to its anatomical position and organization. …”
Get full text

Genital Abnormalities and Growth Retardation as Early Signs of Dilated Cardiomyopathy with Ataxia Syndrome by Kyriaki Papadopoulou-Legbelou, Maria Ntoumpara, Maria Kavga, Eleni P. Kotanidou, Ioannis Papoulidis, Assimina Galli-Tsinopoulou, Maria Fotoulaki

“…We describe a homozygous pathogenic variant in the DNAJC19 gene, diagnosed in Northern Greece, presenting with genital anomalies, growth failure, cardiomyopathy, and ataxia, but without increased urinary 3-methylglutaconic acid and additional presence of vitamin D disorders, hypercalciuria, and osteopenia. …”
Get full text

Malnutrition and Its Influence on Gut sIgA–Microbiota Dynamics by Monica Profir, Robert Mihai Enache, Oana Alexandra Roşu, Luciana Alexandra Pavelescu, Sanda Maria Creţoiu, Bogdan Severus Gaspar

“…Secretory immunoglobulin A (sIgA) plays an important role in maintaining and increasing beneficial intestinal microbiota populations and protecting against pathogenic species. Depletion of beneficial bacterial populations throughout life is also conditioned by malnutrition. …”
Get full text

Cardiac Tamponade from Purulent Pericarditis due to Cutibacterium acnes by Ardalon Farhat-Sabet, Robert Hull, Dustin Thomas

“…Cutibacterium acnes (formerly Propionibacterium acnes) is an anaerobic bacteria that is ubiquitous in skin flora and is commonly thought of as a culture contaminant; however, it does have pathogenic potential. We present a case of purulent pericarditis secondary to C. acnes leading to cardiac tamponade. …”
Get full text

Defective production of interferon-γ and tumour necrosis factor-α by AIDS mononuclear cells after in vitro exposure to Rhodococcus equi by S. Delia, C. M. Mastroianni, M. Lichtner, F. Mengoni, S. Moretti, V. Vullo

“…In such patients, however, the infection with R. equi, a facultative intracellular pathogen which survives and replicates within macrophages, may be responsible for the impairment in the TNF-α release, possibly enhancing the HIV-induced macrophage dysftmction.…”
Get full text

Chemostats and epidemics: Competition for nutrients/hosts by Hal L. Smith, Horst R. Thieme

“…In a chemostat, several species compete for the same nutrient, whilein an epidemic, several strains of the same pathogen may competefor the same susceptible hosts. …”
Get full text

Acholeplasma laidlawii PG8 Culture Adapted to Unfavorable Growth Conditions Shows an Expressed Phytopathogenicity by Vladislav M. Chernov, Natalia E. Moukhametshina, Yurii V. Gogolev, Tatiana N. Nesterova, Maxim V. Trushin, Olga A. Chernova

“…This resulted in more frequent appearance of various morphological alterations when plants of vinca (Vinca minor L.) were infected by adapted mycoplasma cells. The increasing pathogenicity was accompanied by changes in genome expression in these adapted cells. …”
Get full text

Effects of highland barley β-glucan on gut microbiota composition and metabolism in vitro fermentation by Yinchen Ge, Jiaci Liu, Huacheng Tang, Yanqing Zang, Yang Cao

“…The results showed that HBG could enrich microbial diversity, increase the abundance of beneficial bacteria, and inhibit the biology of pathogenic bacteria. In addition, HBG increased the content of short-chain fatty acids and decreased fermentation broth pH. …”
Get full text

A Rare Case of Mediastinal Bronchogenic Cyst Infected by Salmonella enteritidis by Jasleen Kaur, Philip J. McDonald, Ravinder D. Bhanot, Reda A. Awali, Sorabh Dhar, James Rowley

“…Gram-positive, Gram-negative, and mycobacterial infections have been reported, though frequently a pathogen is not identified. We present the case of a 46-year-old female with known history of bronchogenic cyst who presented with suspected postobstructive pneumonia. …”
Get full text

Bacteremia due to Leuconostoc pseudomesenteroides in a Patient with Acute Lymphoblastic Leukemia: Case Report and Review of the Literature by Kazuko Ino, Kazunori Nakase, Kei Suzuki, Akiko Nakamura, Atsushi Fujieda, Naoyuki Katayama

“…Physicians should be aware of Leuconostoc species as causative pathogen if they encounter Gram-positive cocci bacteremia resistant to standard antibiotics such as vancomycin and teicoplanin, especially in patients with hematologic malignancies.…”
Get full text

Bacillus cereus Typhlitis in a Patient with Acute Myelogenous Leukemia: A Case Report and Review of the Literature by James D. Denham, Sowmya Nanjappa, John N. Greene

“…Bacillus cereus is a Gram-positive rod that is now recognized as a rare cause of frank disease in the neutropenic hematologic malignancy patient. Because this pathogen is rarely isolated in clinical specimens, no large studies exist to guide the management of these acutely ill patients. …”
Get full text

Cupriavidus gilardii infection following heart failure: a case report and literature review by Yanwen Liu, Jianxin Gao, Jingyun Ye, Hui Han, Haiyan Zhu

“…Knowledge about the pathogenic characteristics of Cupriavidus gilardii is limited, especially cardiac infection with this bacterium has not been reported. …”
Get full text

Clinical Implications for the Timely Diagnosis of Mycobacterium marinum in the Age of Biologic Therapy: A Case Report and Review of the Literature by Chris J. Lata, Kelle Edgar, Stephen Vaughan

“…A detailed exposure history and high degree of suspicion for this indolent pathogen are often required for the correct diagnosis of this disease. …”
Get full text

Decoding the Genetics of Recurrent Molar Pregnancy by Sumita Mehta, Sunita Bijarnia Mahay, Abhishek Satapathy, Kiran Arora

“…We report the case of a 31-year-old woman with previous three molar pregnancies who on genetic testing was found to be compound heterozygous for pathogenic variants in the NLRP7 gene (c.2738A>G and c.2078G>C). …”
Get full text

Generation of an induced pluripotent stem cell line (UCLi026-A) from a patient with ADCY5-related disease carrying the heterozygous variant c.1253G > A; (p. Arg418Gln) by Sharmin Alhaque, Dimitri Budinger, Barbara Garavaglia, Giovanna Zorzi, Serena Barral, Manju A. Kurian

“…We generated an induced pluripotent stem cell line from the fibroblasts of an affected patient with the common heterozygous pathogenic variant, c.1253G > A (p.Arg418Gln). This line was further characterised for pluripotency, differentiation potential and genomic integrity. …”
Get full text

Lethal Bronzing Disease (LBD) by Brian W. Bahder, Ericka E. Helmick, Nigel A. Harrison, Monica L. Elliott

“…This three-page fact sheet describes the pathogen and hosts of LBD, its symptoms, how to diagnose it, and disease management practices. …”
Get full text

Pyoderma Gangrenosum Mimicking an Infected Wound following Dynamic Hip Screw Fixation by Metin Nizamoglu

“…Although debridement can offer aid in resolving lesions, this is contraindicated in the acute phase as this can cause acceleration of the pathogenic process. Biopsy of the lesion does not offer a definitive diagnosis; therefore suspicion must be maintained as the diagnosis is ultimately a clinical one. …”
Get full text

Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications by Ana-Maria Singeap, Carol Stanciu, Laura Huiban, Cristina Maria Muzica, Tudor Cuciureanu, Irina Girleanu, Stefan Chiriac, Sebastian Zenovia, Robert Nastasa, Catalin Sfarti, Camelia Cojocariu, Anca Trifan

“…Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. …”
Get full text

Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…Over the last decade, countless in-silico methods have been developed to predict the pathogenicity of point mutations on resolved structures, but no studies have evaluated their capabilities on unresolved protein structures predicted by AF2. …”
Get full text