Methylmalonic Acidemia with Novel MUT Gene Mutations by Inusha Panigrahi, Savita Bhunwal, Harish Varma, Simranjeet Singh

“…With advent of NGS, judicious use of NGS with Sanger sequencing can help identify causative possibly pathogenic mutations.…”
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Sample Collection for Ganoderma Butt Rot of Palms by Braham Dhillon, Seemanti Chakrabarti

“…But with the availability of a disease diagnostic assay, this fungal pathogen can be detected using saw dust samples collected from declining palms, several months before symptoms appear. …”
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Antimicrobial Resistance Surveillance Systems: Are Potential Biases Taken into Account? by Olivia Rempel, Johann DD. Pitout, Kevin B. Laupland

“…The objective of this study was to assess potential biases that may influence the validity of contemporary antimicrobial-resistant (AMR) pathogen surveillance systems. Although surveillance data have been widely published and used by researchers and decision makers, little attention has been devoted to the assessment of their validity. …”
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Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions by Sandip Patil, Xiaowen Chen, Feiqiu Wen

“…Pseudomonas aeruginosa, an antibiotic-resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. …”
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Ulcerative Colitis Preceding Asymptomatic Wilson’s Disease: A Case Report and Literature Review by Jun Kunizaki, Yuko Yoto, Yoshinobu Nagaoka, Akira Ishii, Tomoe Kazama, Kohei Wagatsuma, Noriyuki Akutsu, Aki Ishikawa, Toju Tanaka, Shintaro Sugita, Takeshi Tsugawa, Hiroshi Nakase

“…Genetic testing showed pathogenic variants in ATP7B allele 1: c.2004_2006delGAT (p. …”
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Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review by I. Kasiulevičiūtė

“… Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by the presence of benign tumors in many organs. The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. …”
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Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria by Vadim S. Ten, Anatoly Starkov

“…This paper focuses on current data that support a pathogenic role of ROS originating from mitochondrial respiratory chain in the promotion of secondary energy failure and proposes potential therapeutic strategy against reperfusion-driven oxidative stress following hypoxia-ischemia-reperfusion injury of the developing brain.…”
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PDE12 mediated pruning of the poly-A tail of mitochondrial DNA-encoded tRNAs is essential for survival by Chenxiao Yu, Marco Tigano, Erin L Seifert

“…A new study by Van Haute and colleagues (Van Haute et al, 2024) describes the first pathogenic variants in the human PDE12 gene. The 3 missense mutations that were identified each carry severe phenotypic consequences that correlate with the presence or not of residual PDE12 protein, show cell-type-specific adaptive responses, and specificity in the mtDNA-encoded electron transport chain subunits that are most affected. …”
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Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement by Qian Wang, Xuefei Tian, Yuyang Wang, Yan Wang, Jialin Li, Tingting Zhao, Ping Li

“…Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. …”
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Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis by Cai-yun Liu, Jie Zhu, Xiang-Yu Zheng, Chi Ma, Xu Wang

“…Anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum are characteristic features of the disease, thereby suggesting a pathogenic role in the disease. Here, we summarize recent studies that have clearly documented that both clinical manifestations and the antibodies may contribute to early diagnosis and multidisciplinary care. …”
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Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications by Alessia Alunno, Mirko Manetti, Sara Caterbi, Lidia Ibba-Manneschi, Onelia Bistoni, Elena Bartoloni, Valentina Valentini, Riccardo Terenzi, Roberto Gerli

“…In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. …”
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Mild Late-Onset Sensory Neuropathy Associated with Heterozygous Missense GDAP1 Variants by Nivedita U. Jerath

“…This study presents the clinical and electrophysiological findings of four subjects with a pathogenic heterozygous GDAP1 variant causing Charcot–Marie–Tooth disease 2K (CMT2K) and one additional subject with an uncertain GDAP1 variant and clinical findings of CMT 2K. …”
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Managing Pythium Blight in Overseeded Turf by Lawrence Datnoff, Carol Stiles, John Cisar

“…Early in the morning or when the humidity is high, the leaves may be covered with white, cobwebby mycelium of the pathogen, Pythium aphanidermatum. This document is PP-66, one of a series of the Plant Pathology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. …”
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Antibiotic Therapy for Crohn’s Disease: A Review by Simon Lal, A Hillary Steinhart

“…Increasing evidence suggests that gut bacteria play a pathogenic role in Crohn’s disease (CD), providing a rationale for the use of antibiotics in the primary treatment of the disease. …”
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Mathematical Modeling of the Transmission Dynamics of Gumboro Disease by J. S. Musaili, I. Chepkwony, W. N. Mutuku

“…A mathematical model of the transmission dynamics of Gumboro disease is developed in this paper having four compartments of chicken population and one compartment of Gumboro pathogen population. The basic reproduction number Rog is derived, and the dynamical behaviors of both the disease-free equilibrium (DFE) and endemic equilibrium are analyzed using the ordinary differential equation theory. …”
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B Cells in Autoimmune Diseases by Christiane S. Hampe

“…We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells.…”
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Pestalotia Leaf Spot and Fruit Rot of Strawberry by Juliana S. Baggio, Natalia A. Peres

“…Pestalotiopsis-like fungi cause diseases on many different species of plants worldwide, including strawberry. The pathogen is not necessarily new to strawberry and was first reported causing fruit rot in Florida and Israel in the 1970s. …”
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Pestalotia Leaf Spot and Fruit Rot of Strawberry by Juliana S. Baggio, Natalia A. Peres

“…Pestalotiopsis-like fungi cause diseases on many different species of plants worldwide, including strawberry. The pathogen is not necessarily new to strawberry and was first reported causing fruit rot in Florida and Israel in the 1970s. …”
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Managing Pythium Blight in Overseeded Turf by Lawrence Datnoff, Carol Stiles, John Cisar

“…Early in the morning or when the humidity is high, the leaves may be covered with white, cobwebby mycelium of the pathogen, Pythium aphanidermatum. This document is PP-66, one of a series of the Plant Pathology Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. …”
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Biochemistry of the Phagosome: The Challenge to Study a Transient Organelle by Oliver Nüsse

“…The latter is an intracellular organelle that is transformed into a toxic environment within minutes and disappears once the pathogen is destroyed. Reactive oxygen species and reactive nitrogen species are produced inside the phagosome. …”
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