Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning by D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider

“…A negative result of genetic screening for pathogenic variants in genes of the low-density lipoprotein receptor and its ligands does not rule out a diagnosis of familial hypercholesterolemia. …”
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The theses for MD degree by article Editorial

“…Schyokotova — Clinical and laboratory parameters and endothelial dysfunction at liver diseases, their diagnostic, prognostic value and potential of application for treatment response rate ratingA.A. Kurbatova — Pathogenic and clinical value of cytokine and claudin system at irritable bowel syndromeYe.N. …”
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Can the African weaver ant be used as a vector of entomopathogenic fungi to bolster the biological control of tephritid fruit fly pests? by Thibault Nève de Mévergnies, Samba Diop, Massamba Diakhaté, Claire Detrain, Frédéric Bouvery, Thierry Brévault, Anaïs Chailleux

“…Results showed that while M. anisopliae was intrinsically pathogenic to the weaver ants, they were able to detect its presence and adjust their behavior according to its concentration. …”
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Synergistic Enzybiotic Effect of a Bacteriophage Endolysin and an Engineered Glucose Oxidase Against <i>Listeria</i> by David Talens-Perales, José-Antonio Daròs, Julio Polaina, Julia Marín-Navarro

“…Two enzyme-based antimicrobials (enzybiotics) have been combined in a novel treatment against this pathogenic bacterium, resulting in a powerful synergistic effect. …”
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The Silent Threat of Human Metapneumovirus: Clinical Challenges and Diagnostic Insights from a Severe Pneumonia Case by Rubens Carmo Costa-Filho, Felipe Saddy, João Luiz Ferreira Costa, Leandro Reis Tavares, Hugo Caire Castro Faria Neto

“…Background: Human metapneumovirus (hMPV) is a respiratory pathogen that has gained increasing recognition due to advancements in molecular diagnostic tools, which have improved its detection and characterization. …”
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Enhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistant Aeromonas veronii by Xin Cao, Yanqiong Tang, ZhenZhang Lu, Xiang Ma, Hong Li, Xue Chi, Juanjuan Li, Zhu Liu

“…ABSTRACT Aeromonas veronii is a vital zoonotic pathogen known for its extensive drug resistance and ability to form biofilms, which contribute to its antibiotic resistance. …”
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Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China by Zhenhua Guo, Yao Jiang, Peng Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang

“…The genomic characteristics and evolutionary relationship of the pathogenic viral strain were also analyzed.ResultsThe isolate GETV-HeN202309 shared the highest nucleotide identity of 99.8% with strains from Guangdong and Sichuan province, suggesting it is an imported transmission. …”
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The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin by Jin Zeng, Fuyang Song, Yi Yang, Chenjie Ma, Guangcun Deng, Yong Li, Yujiong Wang, Xiaoming Liu

“…However, studies of its pathogenic roles and functional mechanisms have been hampered due to the difficulty of purification and lack of specific antibodies against this toxin. …”
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Personalized allele-specific antisense oligonucleotides for GNAO1-neurodevelopmental disorder by Inna Shomer, Nofar Mor, Shaul Raviv, Noga Budick-Harmelin, Tanya Matchevich, Sharon Avkin-Nachum, Yoach Rais, Rebecca Haffner-Krausz, Ariela Haimovich, Aviv Ziv, Reut Fluss, Bruria Ben-Ze’ev, Gali Heimer, Denis N. Silachev, Vladimir L. Katanaev, Dan Dominissini

“…GNAO1-associated disorders are ultra-rare autosomal dominant conditions, which can manifest, depending on the exact pathogenic variant in GNAO1, as a spectrum of neurological phenotypes, including epileptic encephalopathy, developmental delay with movement disorders, or late-onset dystonia. …”
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Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus by Jinghang Zhou, Yuqi Duan, Menglan Liu, Jinyang Liu, Zenglei Hu, Zhiqiang Duan

“…Additionally, the interactions between these polymerase-associated proteins and host proteins are closely related to the NDV’s replication and pathogenicity. Despite significant progress in understanding the unique and shared functions of NDV polymerase-associated proteins, research on these viral proteins’ structure and function is less comprehensive than other NDV proteins, and the available information is often scattered. …”
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Silver Nanoparticles: Biosynthesis Using an ATCC Reference Strain of Pseudomonas aeruginosa and Activity as Broad Spectrum Clinical Antibacterial Agents by Melisa A. Quinteros, Ivana M. Aiassa Martínez, Pablo R. Dalmasso, Paulina L. Páez

“…This work demonstrates the first helpful use of biosynthesized Ag-NPs as broad spectrum bactericidal agents for clinical strains of pathogenic multidrug-resistant bacteria such as methicillin-resistant S. aureus, A. baumannii, and E. coli. …”
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Urbanization enhances consumer protist-driven ARGs dissemination in riverine ecosystems by Bob Adyari, Lanping Zhang, Ana Maravić, Jiaxin Chen, Laiyi Li, Mahmoud Gad, Chang-Ping Yu, Anyi Hu

“…A higher total abundance of ARGs and a greater number of co-shared ARGs between pathogen and non-pathogen bacteria were observed in the more urbanized western tributary. …”
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A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 by Annejet Heida, Lisette J. M. E. van der Does, Ahmed A. Y. Ragab, Natasja M. S. de Groot

“…Genetic testing identified a mutation of the KCNH2 gene and an unclassified variant, most likely pathogenic, of the KCNE2 gene. This digenic inheritance is extremely rare.…”
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Recurrent NTM pulmonary disease despite avoidance of hot spring exposure in a plaque psoriasis patient treated with Secukinumab: a case report by Yixiao Wei, Chunlei Wang, Lingtao Chong, Xiaojing Cui

“…Conclusions There is potential association between Secukinumab, an IL-17A inhibitor, and NTM disease, echoing anti-TNF biologics’ NTM risk, indicating the urgent need for further research on pathogenic mechanisms and risk factors.…”
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Extensively drug-resistant Acinetobacter baumannii lung abscess and empyema in a patient with fulminant mycoplasma pneumoniae pneumonia by Siyu Yang, Chaojie Wei

“…Acinetobacter baumannii is a pathogen that typically causes nosocomial infections. …”
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The Promising Role of Speckle-tracking Echocardiography in Detecting the Patchy Nature of Myocarditis, Insights from Case Series in the Largest Pediatrics Tertiary Center of UAE by Antoine Fakhry AbdelMassih, Arshad Khan, Zahra Majichian, Afnan Musleh, Ashutosh Goyal, Sara M. AlDarmaki

“…STE was also able to show the specific topography of distribution of each pathogen linked to inflammation.…”
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Susceptibility of Clinical Moraxella catarrhalis Isolates in British Columbia to Six Empirically Prescribed Antibiotic Agents by Tamara Bandet, Sue Whitehead, Edith Blondel-Hill, Ken Wagner, Naowarat Cheeptham

“…BACKGROUND: Moraxella catarrhalis is a commensal organism of the respiratory tract that has emerged as an important pathogen for a variety of upper and lower respiratory tract infections including otitis media and acute exacerbations of chronic bronchitis. …”
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Preventing Foodborne Illness: E. coli O157:H7 by Keith R. Schneider, Renée M. Goodrich Schneider, Michael A. Hubbard, Alexandra Chang

“…Hubbard, and Alexandra Chang, discusses the common foodborne pathogen E. coli O157:H7, especially as it concerns food handlers, processors, and retailers. …”
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Rhodotorula Endogenous Endophthalmitis: A Novel Harbinger of the Injection Drug Epidemic in the United States by Preston M. Luong, Basilio Kalpakian, Lawrence J. Jaeger, Timothy Lahey, Christopher B. Chapman, Michael E. Zegans

“…We report the first case of endogenous endophthalmitis in the United States caused by the emerging fungal pathogen Rhodotorula in an injection drug user which led to no light perception vision (NLP). …”
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Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy and Artificial Neural Networks Applied to Differentiate Escherichia coli papG+/papG- Strains by Łukasz Lechowicz, Wioletta Adamus-Białek, Wiesław Kaca

“…Fimbriae are an important pathogenic factor of Escherichia coli during development of urinary tract infections. …”
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