Modeling dynamic changes in type 1 diabetes progression:Quantifying $\beta$-cell variation after the appearance ofislet-specific autoimmune responses by Patrick Nelson, Noah Smith, Stanca Ciupe, Weiping Zou, Gilbert S. Omenn, Massimo Pietropaolo

“…Our model is able to describe changes in the ratio of pathogenic T cells and regulatory T cells after the appearance of islet antibodies in the pancreas. …”
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Molecular detection of <i>Streptococcus agalactiae</i> in pregnant women and percentage of vertical transmission to their neonates in Babylon province by Ali D. Marhash, Zainab N. Nabat, Nawras A. Abbas

“…Since S. agalactiae is a pathogen of primary concern for public health, this research has been conducted on it. …”
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Evaluation for Retinal Therapy for RPE65 Variation Assessed in hiPSC Retinal Pigment Epithelial Cells by Benjamin M. Nash, To Ha Loi, Milan Fernando, Amin Sabri, James Robinson, Anson Cheng, Steven S. Eamegdool, Elizabeth Farnsworth, Bruce Bennetts, John R. Grigg, Seo-Kyung Chung, Anai Gonzalez-Cordero, Robyn V. Jamieson

“…Results from this study led to reclassification of the synonymous variant to a pathogenic variant, providing the affected patients with access to RPE65 gene replacement therapy.…”
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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…We identified 82 cases with pathogenic or likely pathogenic SNVs and 4 cases with pathogenic CNVs, of which one case with both SNV and CNV. …”
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Recommendation for the use of respiratory syncytial virus vaccines by Ping-Ing Lee, Yhu-Chering Huang, Ching-Chuan Liu, Shee-Uan Chen, Po-Ren Hsueh, Shih-Chi Ku, Po-Yen Chen, Chih-Jung Chen, Yi-Tsung Lin, Chun-Yi Lu, Nan-Chang Chiu, Hsin Chi, Yee-Chun Chen, Feng-Yee Chang, Muh-Yong Yen, Chin-Te Lu, Kuang-Yao Yang, Cheng-Hsun Chiu, Kao-Pin Hwang, Wen-Sen Lee, Ting-Yu Yen, Jen-Fu Hsu, Ying-Chin Lin, Ya-Li Hu, Tzou-Yien Lin

“…Respiratory syncytial virus (RSV) is the most common pathogen for young children hospitalized with bronchiolitis and pneumonia. …”
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New Concepts in the Diagnosis and Pathogenesis of Trichomonas vaginalis by Renuka Bhatt, Mary Abraham, Dino Petrin, Gary E Garber

“…Detection of the factors that are only present in the pathogenic isolates of trichomonads will lead to a better understanding of the epidemiology of this pathogen. …”
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Communication and Synchronization in Disconnected Networks with Dynamic Topology: Moving Neighborhood Networks by Joseph D. Skufca, Erik M. Bollt

“…In particular, we contend that such time-varying networks are important to model in the situation where each agent carries a pathogen (such as a disease) in which the pathogen's life-cycle has a natural time-scale which competes with the time-scale of movement of the agents, and thus with the networks communication channels.…”
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Depression and Anxiety among Patients with Epilepsy and Multiple Sclerosis: UAE Comparative Study by Taoufik Alsaadi, Khadija El Hammasi, Tarek M. Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof

“…This finding could point to the shared pathogenic mechanisms hypothesis between depression and epilepsy.…”
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The Benefits of Early versus Late Therapeutic Intervention in Fabry Disease by Mónica Furlano, Elisabet Ars, Anna Matamala, Vicens Brossa, Joan Martí, Maria del Prado-Venegas, Jaume Crespi, Esther Roe, Roser Torra

“…Fabry disease (FD) is an X-linked lysosomal storage disorder caused by pathogenic variants of the GLA gene. Heterozygous female patients may show much more variability in clinical manifestations, ranging from asymptomatic to full-blown disease. …”
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Comparative Genomic Analysis of Rhodococcus equi: An Insight into Genomic Diversity and Genome Evolution by Jianchao Ying, Jun Ye, Teng Xu, Qian Wang, Qiyu Bao, Aifang Li

“…Rhodococcus equi, a member of the Rhodococcus genus, is a gram-positive pathogenic bacterium. Rhodococcus possesses an open pan-genome that constitutes the basis of its high genomic diversity and allows for adaptation to specific niche conditions and the changing host environments. …”
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Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection by Marion M. Chan, Nagasuresh Adapala, Cui Chen

“…Infection is the outcome of a contest between a pathogen and its host. In the disease leishmaniasis, the causative protozoan parasites are harbored inside the macrophages. …”
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Sympathetic Renal Innervation and Resistant Hypertension by Vito M. Campese, Elaine Ku, Jeanie Park

“…Hypertension in chronic renal disease and renovascular disease is often resistant to therapy. Understanding the pathogenic mechanisms responsible for hypertension in these conditions may lead to improved and more targeted therapeutic interventions. …”
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Strawberry dietary intervention influences diversity and increases abundances of SCFA-producing bacteria in healthy elderly people by Franziska Meiners, Bernd Kreikemeyer, Patrick Newels, Ingmar Zude, Michael Walter, Alexander Hartmann, Daniel Palmer, Georg Fuellen, Israel Barrantes

“…Our findings suggest that a dietary intervention based on strawberries can positively alter the gut microbiota of healthy elderly people as seen in an enrichment of SCFA-producing genera, increased diversity, and a reduction in potentially pathogenic bacteria.IMPORTANCEAging is often associated with changes in the gut microbiome, including a decline in beneficial bacteria and an increase in potentially pathogenic species. …”
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Genome-wide identification of short-chain dehydrogenases/reductases genes and functional characterization of ApSDR53C2 in melanin biosynthesis in Arthrinium phaeospermum by Jiao Liao, Yisi Wang, Han Liu, Sijia Liu, Peng Yan, Hang Chen, Shujiang Li, Shujiang Li

“…Still, the relationship with melanin biosynthesis of A. phaeospermum is not clear.MethodsWe aimed to predict the biological function of the SDR gene family in A. phaeospermum, identify key ApSDR genes with pathogenic roles, and explore the pathogenic mechanism. …”
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Resistance of potato cultivars and hybrid clones from the VIR collection to the northwestern population of <i>Phytophthora infestans</i> by N. M. Zoteyeva, O. S. Kosareva, E. V. Rogozina, N. A. Chalaya

“…Phytophthora infestans (Mont.) de Bary is a well-known pathogen affecting potato plants. Due to the changes in the pathogen population, the late blight disease caused by P. infestans is still difficult to manage. …”
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Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses by Yuying Zhu, Ke Wu, Hanying Wen

“…BackgroundGenomic or exome sequencing is beneficial for identifying more than one pathogenic variation causing blended atypical and/or severe phenotypes. …”
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Juvenile resistance of barleys from the East Asian center of crop origin and domestication to powdery mildew by R. A. Abdullaev, I. N. Anisimova, O. N. Kovaleva, E. E. Radchenko

“…The percentage of accessions susceptible to the studied population of the pathogen was 93.27%.…”
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Identification of novel RIPK4 variants in a Chinese patient with Arthrogryposis Multiplex Congenita (AMC) by Yi-Lei Lu, Meng-wei Liu, Jie-Yuan Jin, Ding Pan

“…Whole-exome sequencing (WES) was employed to determine the genetic etiologies of the patient’s disease. The pathogenic mechanisms of the identified variations were analyzed using protein tolerance profiling and modeling. …”
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Correlation between uterine microbiota and pregnancy outcomes of embryo transfer in overweight and obese women by Ying Yan, Ying Li, Lingling Wu, Yuxuan Zhang, Hong Guo, Yazhong Ji

“…In individuals with higher BMI, pathogenic bacteria are more likely to impair endometrial receptivity, ultimately leading to adverse pregnancy outcomes. …”
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Optimizing a low-temperature preservation technique for Bacillus anthracis strains by A. P. Rodionov, E. A. Artemeva, L. A. Melnikova, D. M. Sahibullina

“…Further research will be focused on duration of the low-temperature preservation that will ensure appropriate viability and biological properties of the pathogen.…”
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