Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris by Lei Ma, HaiBo Xue, Tianqin Gao, MeiLan Gao, YuJie Zhang

“…Notch1 signaling may contribute to the pathogenesis of PV by regulating Th17/Treg immune imbalance.…”
Get full text

Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling by Qishan Chen, Min Jin, Feng Yang, Jianhua Zhu, Qingzhong Xiao, Li Zhang

“…Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. …”
Get full text

CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Conclusion: CRISPR-Cas9 system revolutionized the therapeutic strategies in some solid malignant tumors and leukemia through targeting the key genes involved in the pathogenesis of these cancers.…”
Get full text

MicroRNA-155 Participates in the Expression of LSD1 and Proinflammatory Cytokines in Rheumatoid Synovial Cells by Ziliang Yu, Hao Liu, Jianbo Fan, Feihu Chen, Wei Liu

“…Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 are key proinflammatory cytokines implicated in the pathogenesis of RA. In our study, we investigated whether miRNA-155 participates in the expression of LSD1 and proinflammatory cytokines in rheumatoid synovial cells. …”
Get full text

Laparoscopic versus open left hemicolectomy for left-sided colon cancer: protocol for a systematic review and meta-analysis by Yang Yang, Yong Wang, Lie Yang, Qiang Du, Jianhao Zhang, Xueting Liu

“…However, the efficacy of laparoscopic left hemicolectomy remains unclear due to the differences in pathogenesis and surgical details between left and right colon cancers. …”
Get full text

TNF-α and Microalbuminuria in Patients with Type 2 Diabetes Mellitus by I.-Th. Lampropoulou, M. Stangou, A. Papagianni, T. Didangelos, F. Iliadis, G. Efstratiadis

“…Recent evidence suggests that chronic subclinical inflammation plays a key role in the pathogenesis and progression of diabetic nephropathy. …”
Get full text

Molecular Detection, Phylogenetic Analysis, and Identification of Transcription Motifs in Feline Leukemia Virus from Naturally Infected Cats in Malaysia by Faruku Bande, Siti Suri Arshad, Latiffah Hassan, Zunita Zakaria

“…Additionally, different enhancer motifs likely associated with FeLV related pathogenesis have been identified.…”
Get full text

Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis by Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, Hideo Kochi

“…These findings suggest that the E1𝛼 subunit as part of the native BCOADC complex is an immunogen, and that determinant spreading is involved in the pathogenesis of AMA production.…”
Get full text

Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L by Lakmal Ranathunga, Sachini Abesinghe, Ji-Won Cha, Niranjan Dodantenna, Kiramage Chathuranga, Asela Weerawardhana, D. K. Haluwana, Nuwan Gamage, Jong-Soo Lee

“…Taken together, these results highlight the important role of DP71L with respect to inhibition of interferon responses and provide guidance for a better understanding of ASFV pathogenesis and the development of live attenuated ASFV vaccines.…”
Get full text

Acquired hypothyroidism, iodine status and hearing impairment in adults: A pilot study. by Tereza Grimmichova, Ludmila Verespejova, Zuzana Urbaniova, Martin Chovanec, Martin Hill, Radovan Bilek

“…Despite this, knowledge of the pathogenesis, incidence and severity of hearing impairment remains greatly lacking. …”
Get full text

Enhanced infectivity of bovine viral diarrhoea virus (BVDV) in arginase-producing bovine monocyte-derived macrophages by Lucas José Barone, Nancy Patricia Cardoso, Florencia Celeste Mansilla, Mariángeles Castillo, Alejandra Victoria Capozzo

“…Macrophages are important cells of the innate immunity that play a major role in Bovine Viral Diarrhoea Virus (BVDV) pathogenesis. Macrophages are not a homogenous population; they exist in different phenotypes, typically divided into two main categories: classically (pro-inflammatory) and alternatively activated (anti-inflammatory) or M1 and M2, respectively. …”
Get full text

Application of ursodeoxycholic acid at non-alcoholic and alcohol-induced steatohepatitis by Ye. A. Fedos’ina, M. V. Mayevskaya

“…Article presents pathogenic mechanisms of the most important lesions of the liver – alcoholic and non-alcoholic steatohepatitis in pathogenesis of which the leading part belongs to accumulation of fat in cells of the organ and enhancement of lipid peroxidation processes with development of necrosis of hepatic cells. …”
Get full text

Midline Anterior Neck Inclusion Cyst in a Pediatric Patient: A Case Report and Literature Review with a Dermatologic Perspective by Noemi Brigenti, Rachele Bardelli, Giovanni Paolino, Elisabetta Danese, Paolo Gisondi, Nicola Zerbinati, Giampiero Girolomoni, Andrea Carugno

“…Further research may clarify the pathogenesis and long-term outcomes of these rare lesions.…”
Get full text

The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline by Candan Öztürk, Aynur Özge, Osman Özgür Yalın, İ. Arda Yılmaz, Nuran Delialioglu, Çilem Yıldız, Bahar Tesdelen, Cigdem Kudiaki

“…In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. …”
Get full text

Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization by Yury A. Tyurin, Svetlana A. Lissovskaya, Rustem S. Fassahov, Ilshat G. Mustafin, Anton F. Shamsutdinov, Marina A. Shilova, Albert A. Rizvanov

“…Thus, along with other clinical trials, the study performed would clarify some aspects of molecular pathogenesis of human allergic rhinitis.…”
Get full text

Genetics of Myasthenia Gravis: A Case-Control Association Study in the Hellenic Population by Zoi Zagoriti, Marianthi Georgitsi, Olga Giannakopoulou, Fotios Ntellos, Socrates J. Tzartos, George P. Patrinos, Konstantinos Poulas

“…We focused on three candidate genes which have been clearly associated with several autoimmune diseases, aiming to investigate their potential implication in MG pathogenesis. These are interferon regulatory factor 5 (IRF-5), TNFα-induced protein 3 (TNFAIP3), also known as A20, and interleukin-10 (IL-10), key molecules in the regulation of immune function. …”
Get full text

Tendon-Derived Stem Cell Differentiation in the Degenerative Tendon Microenvironment by Chang Liu, Jing-wan Luo, Ke-ke Zhang, Long-xiang Lin, Ting Liang, Zong-ping Luo, Yong-qing Zhuang, Yu-long Sun

“…Tendinopathy is prevalent in athletic and many occupational populations; nevertheless, the pathogenesis of tendinopathy remains unclear. Tendon-derived stem cells (TDSCs) were regarded as the key culprit for the development of tendinopathy. …”
Get full text

Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice... by Revathee Rajajendram, Chau Ling Tham, Mohamad Nadeem Akhtar, Mohd Roslan Sulaiman, Daud Ahmad Israf

“…The interaction between airway epithelium and inflammatory mediators plays a key role in the pathogenesis of asthma. In vitro studies evaluated the inhibitory effects of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMPF-1), a synthetic chalcone analogue, upon inflammation in the A549 lung epithelial cell line. …”
Get full text

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro by Miao Liu, Wen-jie Xie, Xu Zhang, Wei Wu, Guang Li, Lu Wang

“…Abstract Background Macrophages play an important role in the pathogenesis of ulcerative colitis (UC). We will explore the effects of sodium butyrate (SB) on macrophage function. …”
Get full text

Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression by Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

“…Abstract Histone deacetylase-5 (HDAC5) is implicated in the pathogenesis of depression and the mechanistic pathways underlying the effects of antidepressant medications. …”
Get full text