The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome by Piotr Pasek, Witold Czyż, Julia Kulbacka, Julia Kacperczyk, Marta Chuncia-Ileczko, Michalina Wójcikiewicz, Filip Arczewski, Karol Dziedzic, Maciej Wojszczyk, Damian Zys, Julia Ryniecka

“…Purpose The object of this review is to assess whether aPS/PT complex serves as an effective diagnostic marker in the pathogenesis of complications associated with APS and other connective tissue disorders. …”
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High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test by Ting-Yun Lin, Wei-Kai Wu, Szu-Chun Hung

“…Abstract Indoxyl sulfate (IS) has been implicated in the pathogenesis of cardiovascular diseases. IS is converted from indole, a metabolite of dietary tryptophan through the action of gut microbial tryptophanase, by two hepatic enzymes: CYP2E1 and SULT1A1. …”
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IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-γ occurs via the G-protein pathway by S. Vassiliadis, G. K. Papadopoulos

“…Major histocompatibility complex (MHC) class II antigen expression has been implicated in the pathogenesis of autoimmune type 1 diabetes. In this study we examined the role of various cytoldnes that may induce MHC class II surface antigen expression, using the rat insulinoma line RIN-5AH as a pertinent model system. …”
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Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2 by Qibing Gu, Xiayu Zhu, Jiale Ma, Tao Jiang, Zihao Pan, Huochun Yao

“…Taken together, these findings indicate that the type II TA system ParDE plays a significant role in the pathogenesis of S. suis, providing new insights into its pathogenic mechanisms.…”
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Rare forms of nonalcoholic fatty liver disease: hereditary lysosomal acid lipase deficiency by M. V. Mayevskaya, V. T. Ivashkin, M. S. Zharkova, T. P. Nekrasova, G. I. Ayusheva, R. V. Maslennikov

“…This overview is devoted to more clinically relevant form of DLAL, significant for physicians and gastroenterologists - CESD which is often mistaken for NAFLD, however these diseases have different etiology, pathogenesis, pathomorphology and clinical course. Criteria of the clinical and pathomorphological differential diagnosis of DLAL and NAFLD are presented in the review, modern methods DLAL diagnosis confirmation and treatment perspectives are presented. …”
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Emerging Evidence concerning the Role of Sirtuins in Sepsis by Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng

“…To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis. Notably, downstream mechanisms of sirtuins are not fully understood. …”
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Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…Collectively, our findings suggest that sEH plays an important role in the pathogenesis of experimental obstructive nephropathy and may be a therapeutic target for the treatment of obstructive nephropathy-related diseases.…”
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STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis by Jianfen Zhu, Yijing Chen, Yulan Chen, Yinqiu Lv, Tianxin Chen

“…FLLL32 combined with methylprednisolone therapy significantly inhibited the STAT3 activation, improved acute kidney damage, reduced the interstitial infiltration of inflammatory cells and decreased the AKI incidence in MRL/lpr mice.Conclusion STAT3 activation may play an important role in the pathogenesis of DPLN and the development of AKI. Hence, STAT3 inhibition based on the combination of FLLL32 with methylprednisolone may represent a new strategy for treatment of DPLN with AKI.…”
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Proanthocyanidin from Grape Seed Extracts Protects Indomethacin-Induced Small Intestinal Mucosal Injury by Dae Young Cheung, Jin Il Kim, Soo-Heon Park, Jae Kwang Kim

“…Excessive oxidative stress and free radical production are major components in the pathogenesis of NSAID-induced small intestinal injury. …”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson’s disease (PD). …”
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New treatment options for generalized myasthenia gravis by Antanas Vaitkus, J. Čiauškaitė, M. Malakauskaitė, M. Baublytė

“…Increasing attention is being paid to antibodies against acetylcholine receptors (AChRs) and other structures of the neuromuscular junction that are important in pathogenesis of myasthenia gravis. Drugs are being developed that target specific links in the immune system to reduce the risk of systemic adverse effects. …”
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Hemophagocytic Lymphohistiocytosis in a Patient with Classical Hodgkin Lymphoma by G. Hyun, K. J. Robbins, N. Wilgus, L. Grosso, S. D. Goyal

“…Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome that can be associated with inherited genetic mutations, malignancy, autoimmune disorders, and viral infections. Though the pathogenesis is not fully known, HLH is understood to be a reactive process in the setting of uncontrolled activation of macrophages, CD8+ cytotoxic lymphocytes, and other immune cells. …”
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Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement by Qian Wang, Xuefei Tian, Yuyang Wang, Yan Wang, Jialin Li, Tingting Zhao, Ping Li

“…Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). …”
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Supplementation with Branched-Chain Amino Acids Induces Unexpected Deleterious Effects on Astrocyte Survival and Intracellular Metabolism with or without Hyperammonemia: A Prelimin... by Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa

“…Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic effects on astrocytes. …”
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Autophagy Mediates MMP-2 Expression in Glaucomatous Trabecular Meshwork Cells by Yan-Ling Xiao, Xiao-Rui Wang, Kejing Ye, Wan-Zhu Chen, Bing-Ru Zheng, Yi-Hong Huang, Yu-Yu Wu

“…Autophagy may be involved in the pathogenesis of POAG via regulating the expression of MMP-2 and, subsequently, the deposition of the extracellular matrix.…”
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Comparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma by Maryam Mahdizadeh, Nazanin Mahdavi, Ali Bijani, Fatima Bijani

“…Conclusions it is concluded that calretinin does not play a role in the pathogenesis and histogenesis of COC epithelium, but since ghost cells are caused by a degenerative process, the possibility of involving calretinin as an apoptotic factor in the formation of these cells is supported.…”
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Mechanisms of trematodiases pathogenicity: the presence of the secretory proteins from the liver fluke Opisthorchis felineus in the gallbladder tissues of the patients with chronic... by M. Y. Pakharukova, A. V. Kovner, A. N. Trigolubov, E. N. Fedin, E. S. Mikhailova, S. G. Shtofin, A. I. Autenshlyus, V. A. Mordvinov

“…The results are important for understanding the molecular mechanisms of opisthorchiasis pathogenesis, as well as for improvement of the immunodiagnostics of the opisthorchiasis and opisthorchiasis-related diseases.…”
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Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response by Yumei Ning, Kun Lin, Jun Fang, Xiaojia Chen, Xinyi Hu, Lan Liu, Qiu Zhao, Haizhou Wang, Fan Wang

“…Ulcerative colitis (UC) is a complex intestinal inflammation with an increasing risk of colitis-associated colorectal cancer (CAC). However, the pathogenesis is still unclear between active UC and inactive UC. …”
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BMSCs Interactions with Adventitial Fibroblasts Display Smooth Muscle Cell Lineage Potential in Differentiation and Migration That Contributes to Neointimal Formation by Y. Wendan, J. Changzhu, S. Xuhong, C. Hongjing, S. Hong, Y. Dongxia, X. Fang

“…Our results indicate that the pathogenesis of vascular remodeling might perform via TGF-β1/Smad3 signal transduction pathways.…”
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Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3 by Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo

“…The human renin gene has been widely known to be involved in essential hypertension (EH) pathogenesis. Genetic variant C-5434T of REN enhancer contributed to renin gene transcription and serum renin regulation. …”
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