Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin by Giuseppe Stinco, Cinzia Buligan, Enzo Errichetti, Francesca Valent, Pasquale Patrone

“…This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions.…”
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Migraine and restless legs syndrome – is there an association? by D. Bučaitė, J. Normantas, G. Žemgulytė

“…Although the relationship between migraine and restless legs syndrome and their pathogenesis is not fully understood, current research suggests that these diseases may be related. …”
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Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

“…The details of AD pathogenesis have not been fully elucidated, and a comprehensive gene expression analysis of the process leading up to the onset of AD would be helpful for understanding the mechanism. …”
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Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis by Jiancheng Lv, Ping-an Chang, Xin Li, Xiao Yang, Jie Han, Hao Yu, Zijian Zhou, Haiwei Yang, Pengchao Li, Jiexiu Zhang, Qiang Lu

“…The findings of this study provide a deep understanding of the circRNA-related competitive endogenous RNA regulatory mechanism in BCa pathogenesis.…”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Significant changes in these proteins can indicate the molecular mechanisms involved in the pathogenesis of AD, and they have the potential to serve as AD biomarkers. …”
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Association of disease activity with programmed cell death 1 and its ligand programmed cell death ligand 1 expressions in lupus patients by Eman Eissa, Rania Kandil, Nehal El-Ghobashy, Walaa Abdelfattah, Zainab Hammouda, Sara Medhat Gadelsayed, Faten Bayoumi

“…Background: Programmed cell death 1(PD-1)/programmed cell death ligand 1 (PD-L1) pathway is an immune checkpoint implicated in immune tolerance and involved in the pathogenesis of several autoimmune diseases. Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple immune dysregulation. …”
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Human Urinary Kallidinogenase Reduces Lipopolysaccharide-Induced Neuroinflammation and Oxidative Stress in BV-2 Cells by Zhongyan Zhao, Zhiyu Xu, Tao Liu, Shixiong Huang, Huai Huang, Xiaoyun Huang

“…Neuroinflammation and oxidative stress both play important roles in the pathogenesis of migraine. Human urinary kallidinogenase (UK) is a tissue kallikrein derived from human urine. …”
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Erenumab effectiveness and safety: comparison of real-life data and clinical trial results by Austėja Dapkutė, K. Ryliškienė

“…Erenumab was the first preventive medication targeted to the pathogenesis of migraine to reach Lithuanian market. …”
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Acute Liver Failure Caused by Amanita phalloides Poisoning by Luca Santi, Caterina Maggioli, Marianna Mastroroberto, Manuel Tufoni, Lucia Napoli, Paolo Caraceni

“…The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion of Amanita phalloides, which represents the most common and deadly cause of mushroom poisoning. …”
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Psychological Therapies in Patients with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Osama Altayar, Varun Sharma, Larry J. Prokop, Amit Sood, Mohammad Hassan Murad

“…Psychosocial factors are believed to contribute to the pathogenesis of IBS. Objective. To evaluate the evidence for psychological therapies in IBS treatment. …”
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Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma by G. Di Lorenzo, P. Mansueto, M. Melluso, G. Morici, F. Norrito, D. Cigna, G. Candore, C. Caruso

“…These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis.…”
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A New Experimental Infection Model in Ferrets Based on Aerosolised Mycobacterium bovis by Lyanne McCallan, David Corbett, Peter L. Andersen, Claus Aagaard, David McMurray, Claire Barry, Suzan Thompson, Samuel Strain, Jim McNair

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Physiopathology of Bone Modifications in β-Thalassemia by Carlo Perisano, Emanuele Marzetti, Maria Silvia Spinelli, Cinzia Anna Maria Callà, Calogero Graci, Giulio Maccauro

“…β-thalassemia major (βTM) or Cooley anemia is characterized by significantly reduced or absent synthesis of β-globin chains, which induces important pathologic consequences including hemolytic anemia, altered erythropoiesis, and bone marrow overstimulation. The pathogenesis of bone changes in patients with βTM is not yet completely understood. …”
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Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models by Gang Huang, Xu-Chen Xu, Jie-Sen Zhou, Zhou-Yang Li, Hai-Pin Chen, Yong Wang, Wen Li, Hua-Hao Shen, Zhi-Hua Chen

“…Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.…”
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Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review by Yue Lang, Fengna Chu, Donghui Shen, Weiguanliu Zhang, Chao Zheng, Jie Zhu, Li Cui

“…In this review of latest literatures, we comprehensively tease out diverse roles of different kinds of inflammasomes in neuroimmune and neurodegenerative diseases, especially in the perspective of double roles involved in pathogenesis, and identify future research priorities.…”
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Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis by Wenqiang Yu, Jinfang Song, Shuangquan Chen, Jiayi Nie, Chujun Zhou, Jiamin Huang, Hua Liang

“…A critical event in the pathogenesis of kidney fibrosis is the transition of macrophages into myofibroblasts (MMT). …”
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Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes by Peng Duan, Min Yang, Meilin Wei, Jia Liu, Ping Tu

“…The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.…”
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Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy by Li Wang, Baisheng Lin, Feixiang Wang, Zili Dai, Guofeng Xie, Jian Zhang

“…These findings elucidate novel relationships between PANoptosis-related genes mediated by EDCs and the pathogenesis of HNSC.…”
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CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation by Sera Nakisli, Kayleigh Fanelli, Julia LaComb, Lily J. Arnold, Corinne M. Nielsen

“…Here, we used a mouse model of brain arteriovenous malformation (bAVM)—mediated by endothelial loss of Recombination signal binding protein for immunoglobulin kappa J region (Rbpj)—to investigate changes to brain resident macrophage states during neurovascular disease pathogenesis. We found increased area of Ionized calcium-binding adapter molecule 1 (Iba1) expression in Rbpj-deficient bAVM tissue, as well as Iba1 + cell hypertrophy, increased cell number, and hyperproliferation within areas of increased Iba1 + density. …”
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Bladder Leiomyoma with Synchronous Solitary Fibrous Tumor of the Pleura by Charalampos Mavridis, George Georgiadis, Eleni D. Lagoudaki, Iordanis Skamagkas, Ioannis Heretis, Anastasios V. Koutsopoulos, Charalampos Mamoulakis

“…Solitary fibrous tumors (SFTs) are also rare neoplasms of mesenchymal origin with malignant potential usually affecting the pleura. The pathogenesis of SFTs remains unclear. We report the case of a 28-year-old male presenting with SFT of the pleura and synchronous BL. …”
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