GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway by Wenjing Xue, Ying Li, Yanna Ma, Feng Zhang

“…Overall, our study provides insights into the molecular mechanisms underlying MM pathogenesis and highlights the potential of targeting GDF15-TGFβ signaling -glycolysis axis as a therapeutic approach for future therapeutic interventions in MM.…”
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Endothelial Progenitors as Tools to Study Vascular Disease by Reinhold J. Medina, Christina L. O'Neill, T. Michelle O'Doherty, Sarah E. J. Wilson, Alan W. Stitt

“…The use of OECs for modelling vascular disease will contribute greatly to improving our understanding of endothelial pathogenesis, which will potentially lead to the discovery of novel therapeutic strategies for vascular diseases.…”
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Hyperparathyroidism in Patients with End-Stage Chronic Liver Disease (Clinical Observations) by A. A. Lavreniuk, A. N. Gorbacheva, E. E. Bibik, A. K. Eremkina, I. N. Tikhonov, N. G. Mokrysheva

“…Bone diseases such as osteoporosis and osteomalacia are quite common in chronic liver disease, especially in cirrhosis and cholestatic diseases; however, the pathogenesis of these disorders and their relationship with mineral metabolism remain poorly understood. …”
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Association between oxidative balance score and gallstone disease: a population-based study from NHANES by Mengmeng Zhang, Aiming Yang

“…BackgroundOxidative stress has been reported to participant in the pathogenesis of gallstones. Oxidative balance score (OBS) represents pro-oxidant and antioxidant exposures to diet and lifestyle, closely associated with multiple metabolic disorders. …”
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Aortoenteric Fistula as a Complication of Open Reconstruction and Endovascular Repair of Abdominal Aorta by Marek Tagowski, Hendryk Vieweg, Christian Wissgott, Reimer Andresen

“…Mechanical injury, infection, and adherence of a bowel segment to the aorta or aortic graft are major etiologic factors of AEF after open aortic repair. The pathogenesis of AEF formation after endovascular abdominal aortic repair is related to mechanical failure of the stent-graft, to stent graft infection, and to persistent pressurization of the aneurysmal sac. …”
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Vegetative status in patients with transient ischemic attack and stroke by N. V. Halinouskaya, S. V. Samsonau

“…The key difference between TIA and TS is a difference in the relationship between the humoral regulation of the activities of the ANS and the parasympathetic part activity at the 1st day, which determines specific features of pathogenesis of the transient ischemia. …”
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Anti-ribosomal P2: could it be a useful new criterion for patients with systemic lupus erythematosus? by Menna N. Hemdan, Tayseer Khedr, Samar H. Goma, Fatma Mohammed Helbawi Mohammed, Maha S. I. Abdelrahman

“…It is closely linked to the pathogenesis of neuropsychiatric lupus. Further studies are required to assess anti-ribosomal antibody subunits’ diagnostic and clinical value.…”
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Discovery of Novel Leaf Rust Responsive microRNAs in Wheat and Prediction of Their Target Genes by Dhananjay Kumar, Dharmendra Singh, Pulkit Kanodia, Kumble Vinod Prabhu, Manish Kumar, Kunal Mukhopadhyay

“…The present study provides insight into potential miRNAs with probable roles in leaf rust pathogenesis and their target genes in wheat which establish a foundation for future studies.…”
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Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy by Xingren Liu, Xin Wang, Xue Wu, Shuhua Zhan, Yan Yang, Caiyu Jiang

“…Abstract Chronic pulmonary diseases pose a prominent health threat globally owing to their intricate pathogenesis and lack of effective reversal therapies. …”
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Lymphocyte levels in Crohn’s disease patients in clinical remission are significantly lower than those in healthy people by Asi He, Tulan Hu, Linzhen Li

“…Lymphocytes migration is involved in the pathogenesis of IBD. The purpose of this study was to evaluate whether there were differences in blood lymphocytes levels between IBD patients in clinical remission and healthy people. …”
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Outer Membrane Vesicles Derived from Adherent-Invasive Escherichia coli Induce Inflammatory Response and Alter the Gene Expression of Junction-Associated Proteins in Human Intestin... by Bahareh Nadalian, Banafsheh Nadalian, Mohammad Reza Zali, Abbas Yadegar

“…However, further investigations are needed to elucidate the putative role of OMVs in the pathogenesis of AIEC and IBD.…”
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The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease by Zhenzhen Lu, Yifei Zhong, Wangyi Liu, Ling Xiang, Yueyi Deng

“…Although some achievements have been made in the exploration of the pathogenesis of DKD, the currently available clinical treatment methods are still not completely effective in preventing the progress of DKD to ESRD. …”
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Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis by Jiayin Wang, Dandan Jia, Zhiwang Zhang, Dan Wang

“…The disruption of mitochondrial homeostasis is implicated in the pathogenesis of sarcopenia. Exercise training effectively delays the onset of sarcopenia by significantly maintaining mitochondrial homeostasis, including promoting mitophagy, improving mitochondrial biogenesis, balancing mitochondrial dynamics, and maintaining mitochondrial redox. …”
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Lipidomics of Huntington’s Disease: A Comprehensive Review of Current Status and Future Directions by Ali Yilmaz, Sumeyya Akyol, Nadia Ashrafi, Nazia Saiyed, Onur Turkoglu, Stewart F. Graham

“…Despite a limited understanding of its pathogenesis, research has implicated abnormal trinucleotide cytosine-adenine-guanine CAG repeat expansion in the huntingtin gene (HTT) as a critical factor. …”
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Oxidative and Antioxidative Stress Status in Children with Inflammatory Bowel Disease as a Result of a Chronic Inflammatory Process by Urszula Grzybowska-Chlebowczyk, Paulina Wysocka-Wojakiewicz, Martyna Jasielska, Bożena Cukrowska, Sabina Więcek, Maria Kniażewska, Jerzy Chudek

“…Oxidative stress (OS) has been recently implicated in the disease pathogenesis in inflammatory bowel disease (IBD). The aim of the study was to evaluate oxidative and antioxidative stress status and the risk of the atherosclerotic process in children with IBD and functional gastrointestinal disorders (FGID). …”
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Link-Polymorphism of 5-HTT Promoter Region Is Associated with Autoantibodies in Patients with Systemic Lupus Erythematosus by Shu Li, Shuang Liu, Fan Chen, Yuqi Cheng, Ru Bai, Aiyun Lai, Zhaoping Lu, Jian Xu

“…To explore whether 5-HTTLPR plays a role in the pathogenesis of SLE, we tested 138 SLE patients and 138 age and sex matched health controls (HCs) for 5-HTTLPR by polymerase chain reaction (PCR) and agarose gel electrophoresis. …”
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Treatment Challenges in a Tourette Syndrome Patient with Self-Injurious Behaviour: Case Report and Literature Review by G. Asadauskaitė, G. Jasionytė, M. Karnickas

“…During hospitalization, insomnia was resolved, whereas motor tics and self-harm decreased.Discussion. The pathogenesis of Tourette syndrome emphasizes the dysfunction of neuronal networks in the basal ganglia. …”
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Resistant stomach ulcer at Cushing disease: clinical case by N. V. Novozhilov, Yu. O. Shulpekoa, S. V. Mironov, Ye. K. Baranskaya, A. A. Sheptulin, V. T. Ivashkin

“…During the further investigation: low-dose dexamethasone suppression test, magnetic-resonance tomography (MRI) and computer tomography (CT) of the brain and abdominal cavity data, favoring the Cushing disease (ACTH-producing pituitary adenoma), was obtained. Pathogenesis of chronic stomach ulcer is complex: effect of H.pylori infection, drugs (NSAID, steroids) and hypercorticoidism. …”
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A Thickened Coracohumeral Ligament and Superomedial Capsule Limit Internal Rotation of the Shoulder Joint: Report of Three Cases by Masashi Koide, Junichiro Hamada, Yoshihiro Hagiwara, Kenji Kanazawa, Kazuaki Suzuki

“…Although the precise pathogenesis of frozen shoulder is unclear, thickened capsule and coracohumeral ligament (CHL) have been documented to be one of the most specific manifestations. …”
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RIPK1 in necroptosis and recent progress in related pharmaceutics by Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li

“…RIPK1-mediated necroptosis further promotes cell death and inflammation in the pathogenesis of liver injury, skin diseases, and neurodegenerative diseases. …”
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