Association between extracellular DNA levels, markers of inflammation and left ventricular mass index in children with chronic kidney disease by Ylva Tranæus Lindblad, Ľubomíra Tóthová, Peter Celec, Karolina Kublickiene, Peter Bárány, Milan Chromek

“…We believe that our results contribute new knowledge to the pathogenesis of CKD and its complications and may help identify new treatment targets.…”
Get full text

Tumor Necrosis Factor-Alpha Gene Promoter Region Polymorphism and the Risk of Coronary Heart Disease by Gul Zareen Asifa, Afrose Liaquat, Iram Murtaza, Syed Ali Raza Kazmi, Qamar Javed

“…The TNF-α  −863C>A gene polymorphism was associated with the pathogenesis of CHD while the −1031T>C polymorphism did not show any link with the disease in a Pakistani population.…”
Get full text

Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester by Hongwei Li, Qian Yin, Ning Li, Zhenbo Ouyang, Mei Zhong

“…Oxidation status increased in GDM, especially protein oxidation, which may contribute to the pathogenesis of GDM.…”
Get full text

Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice by Yong Xie, Yi Zhang, Zebin Guo, Hongliang Zeng, Baodong Zheng

“…The present results supported the view that the pathogenesis of NAFLD was complex with inflammation, together with increasing serum glucose and IR. …”
Get full text

Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey by Nataša Milošević, Maja Milanović, Milica Medić Stojanoska, Varomyalin Tipmanee, Ilias Smyrnioudis, George V. Dedoussis, Nataša Milić

“…Based on the modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic liver disease (MASLD) to highlight the metabolic aspect of liver pathogenesis. Chios mastiha (<i>Pistacia lentiscus</i> var. …”
Get full text

Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association by Lorenzo Cavagna, Nicola Boffini, Giovanni Cagnotto, Flora Inverardi, Vittorio Grosso, Roberto Caporali

“…The proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-6, involved in the pathogenesis of RA, are also independently predictive of subsequent cardiovascular disease (CVD). …”
Get full text

Pain in Parkinson's Disease Associated with COMT Gene Polymorphisms by Wanjun Li, Yongqian Chen, Bowen Yin, Limei Zhang

“…PD patients present high incidence of pain with unknown pathogenesis. Objective. We investigated the relation of COMT polymorphisms rs4633 and rs6267 with PD pain. …”
Get full text

Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology? by Monika Adamczyk-Sowa, Aldona Medrek, Paulina Madej, Wirginia Michlicka, Pawel Dobrakowski

“…Gut microbiota may be of a great importance in the pathogenesis of MS, since recent findings suggest that substitutions of certain microbial population in the gut can lead to proinflammatory state, which can lead to MS in humans. …”
Get full text

The Association between Hypertension and Dementia in the Elderly by Michiya Igase, Katsuhiko Kohara, Tetsuro Miki

“…In connection to this, some studies have suggested that HT in old age correlates with the pathogenesis of dementia. Since HT is potentially reversible, a number of randomized trials have examined whether antihypertensive treatment may help in preventing dementia occurrence. …”
Get full text

Neuroinflammation and Oxidative Stress in Diabetic Neuropathy: Futuristic Strategies Based on These Targets by Reddemma Sandireddy, Veera Ganesh Yerra, Aparna Areti, Prashanth Komirishetty, Ashutosh Kumar

“…Several theories of etiologies surfaced down the lane, amongst which the oxidative stress mediated damage in neurons and surrounding glial cell has gained attention as one of the vital mechanisms in the pathogenesis of neuropathy. Mitochondria induced ROS and other oxidants are responsible for altering the balance between oxidants and innate antioxidant defence of the body. …”
Get full text

Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients by Joanna Bartosińska, Ewelina Zakrzewska, Dorota Raczkiewicz, Joanna Purkot, Anna Michalak-Stoma, Małgorzata Kowal, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos

“…Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.…”
Get full text

Regulator of Calcineurin 1 in Periodontal Disease by Ulrike Peters, Eleni Solominidou, Yüksel Korkmaz, Stefan Rüttermann, Astrid Klocke, Thomas Frank Flemmig, Thomas Beikler

“…Nuclear factor of activated T-cells (NFAT) and NF-kB pathway associated processes are involved in the pathogenesis of various inflammatory disorders, for example, periodontal disease. …”
Get full text

Recent Advances in Vaginal Atresia: A Literature Review by Xijuan Lin, Jia Kang, Lan Zhu

“…In this context, this article systematically reviews the epidemiological characteristics of vaginal atresia and explores its etiology from multiple perspectives, including developmental processes, genetic factors, and environmental factors, emphasizing the importance of genetic susceptibility and environmental interactions in the pathogenesis of the condition. Building upon a summary of the clinical presentations, classification, and diagnostic methods of vaginal atresia, this article provides an overview of current treatment strategies for both partial vaginal atresia and complete vaginal atresia, discusses the psychological status of affected patients, and examines fertility outcomes and sexual function. …”
Get full text

Specific Activity of Lactate Dehydrogenase in Muscle and Liver Tissues of Rats Exposed to Intermittent Hypobaric Hypoxia by Syarifah Dewi, Adiba Nur Ashri Ramadhani, Khoiriyyah Amalia Az-zahra, Wardaya Wardaya

“…This finding could be implemented in individuals who experience intermittent hypoxia exposures or in various diseases with hypoxic conditions as their pathogenesis.…”
Get full text

Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy by Tianyao Gong, Dongmei Wang, Dongmei Wang, Jinyan Wang, Qun Huang, Haiyan Zhang, Chunmeng Liu, Xinglin Liu, Hejiang Ye

“…Oxidative stress is an important pathogenesis of diabetic retinopathy. Plant metabolites can be divided into two types: primary metabolites and secondary metabolites, secondary metabolites are the main active components and important sources for developing new drugs. …”
Get full text

Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming by Pengfei Ji, Sasicha Manupipatpong, Nina Xie, Yujing Li

“…More importantly, the applications of iPSC in the development of disease models such as neurodegenerative disorders greatly enhance our understanding of the pathogenesis of such diseases and also facilitate the development of clinical therapeutic strategies using iPSC generated from patient somatic cells to avoid an immune rejection. …”
Get full text

A potential VEGF-driven hypothesis of calvarial centripetal proliferation in cerebral proliferative angiopathy by Shigeta Miyake, Timo Krings, Tze Phei Kee, Thierry A. G. M. Huisman

“…Herein, we investigated the presence of calvarial thickening in patients with CPA, and discuss its potential pathogenesis. This retrospective multicenter cohort study enrolled 16 CPA patients from our institutions. …”
Get full text

Combined Treatment with Zinc Aspartate and Intravenous Immunoglobulins (IVIGs) Ameliorates Experimental Autoimmune Encephalomyelitis (EAE) by Diana Straubel, Anja Thielitz, Annegret Reinhold, Kurt Grüngreiff, Dirk Reinhold

“…., multiple sclerosis (MS), an inflammatory autoimmune disorder with a clear T cell-mediated immune pathogenesis. The trace element zinc is shown to play a regulatory role in the maintenance of immune functions. …”
Get full text

Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue by Ennio Giulio Favalli, Francesco Grossi, Alberto Batticciotto, Matteo Filippini, Simone Parisi, Ombretta Viapiana, Paolo Gisondi, Paolo Dapavo, Lorenzo Dagna, Filippo De Braud

“…Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. …”
Get full text

Presence of Serum Antinuclear Antibodies Does Not Impact Outcomes in HBV-Related Acute-on-Chronic Liver Failure by Lin Lin, Bin Lin, Qing Lan, Longgen Liu, Jianchun Lu, Xiujun Zhang, Shuqin Zheng, Yuan Xue

“…Positive ANA is frequent in HBV-related ACLF, and it does not seem to be associated with poor outcomes, but the pathogenesis of ACLF may be different between ANA (+) and ANA (−) groups.…”
Get full text