Distinct disruptions in CA1 and CA3 place cell function in Alzheimer’s disease mice by Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J. Kim, Jeiwon Cho, Yeowool Huh

“…These findings elucidate that distinct physiological perturbations in CA1 and CA3 place cells, coupled with disrupted hippocampal theta rhythmicity in CA1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in AD pathogenesis.…”
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The Role of Monocyte/Macrophage and CXCR3 in Differentiation between Recurrent Hepatitis C and Acute Cellular Rejection Postliver Transplantation by Asmaa Ibrahim Gomaa, Nermine Ahmed Ehsan, Ahmed A. Elrefaei, Mervat Mohamed Sultan, Maha Mohamed Elsabaawy

“…Hepatic macrophages, which can either arise from circulating blood-derived monocytes (BDM) or from resident tissue Kupffer cells, are central in the pathogenesis of chronic liver injury. The aim of this work was to evaluate whether the origin of macrophages and the immune mediator CXCR3 could help in differentiating between acute recurrent HCV and ACR after liver transplantation. …”
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A Rare Case of Proximal Junctional Failure with Delayed Infection after Adult Spinal Deformity Surgery: A Report of Two Cases by Takuro Iwami, Mitsuru Yagi, Eijiro Okada, Satoshi Suzuki, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Kota Watanabe, Nobuyuki Fujita, Masaya Nakamura, Morio Matsumoto

“…Additional studies on this phenomenon are warranted to elucidate the pathogenesis of this complication.…”
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Cellular Mechanisms of Multiple Myeloma Bone Disease by Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano

“…Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.…”
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Identifying Key Biomarkers and Immune Infiltration in Female Patients with Ischemic Stroke Based on Weighted Gene Co-Expression Network Analysis by Haipeng Xu, Kelin He, Rong Hu, YanZhi Ge, Xinyun Li, Fengjia Ni, Bei Que, Yi Chen, Ruijie Ma

“…After that, we explored the specific molecular and biological functions of these hub genes to gain a better understanding of the underlying pathogenesis of female IS patients. Moreover, the “Cell type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT)” was used to examine the distribution pattern of immune subtypes in female patients with IS and normal controls, revealing a new potential target for clinical treatment of the disease.…”
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Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology by Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Akihiro Ueda, Mizuki Ito, Mizuki Ito

“…We propose an “ATP Supply–Demand Mismatch Model” to help explain the pathogenesis of PD. This model emphasizes how ATP deficits drive pathological protein aggregation, impaired autophagy, and the degeneration of key brain networks, contributing to both motor and non-motor symptoms.…”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…Recent findings showed that murine podocytes could undergo epithelial-mesenchymal transformation (EMT), suggesting new hypotheses about the pathogenesis of glomerular fibrosis. Here, we show that also human podocytes can undergo EMT, but more importantly nephrin ablation itself can trigger this phenotypic transformation. …”
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Relationship of Biochemical and Sonographic Markers with Disease Severity in Rosacea Patients Without Cardiovascular Disease by Banu Ismail Mendi, Bokebatur Ahmet Rasit Mendi, Banu Farabi, Mehmet Fatih Atak

“…There is ongoing debate regarding rosacea as a cutaneous disease with systemic inflammatory effects and its associations with cardiovascular diseases. Although the pathogenesis of both atherosclerosis and rosacea demonstrate notable similarities, particularly in the central role of inflammation, significant gaps in understanding these connections remain. …”
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Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway by Dongling Guo, Yu Du, Xin Liu, Dan Li, Ling Wei, Xiangjia Zhu

“…Abstract Highly myopic cataract (HMC) is a leading cause of blindness among the working-age individuals, with its pathogenesis poorly understood. This study aimed to elucidate the role of ferroptosis in HMC development as well as the underlying mechanisms. …”
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Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome by Jingru Sui, Dan Guo, Xiao Wen, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu

“…Overall, the study characterizes the full spectrum of splicing dysregulation patterns, indicating the similarity and specificity of splicing‐derived pathogenesis across 31 human solid tumors.…”
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Evaluation of lipid profile in patients with cherry angioma: A case–control study in Iraqi patients by Mohammed K. Al-Hattab, Ansaar H. Gahlool, Jinan H. Al-Kalidi

“…Conclusion: Based on its outcomes, the study proposed that dyslipidemia could play a vital role in the pathogenesis of CA lesions. Hence, dyslipidemia treatments may represent an effective means for CA therapy.…”
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PCSK9: A Potential Therapeutic Target for Sepsis by Yuan Yuan, Wei Wu, Shanshan Sun, Yi Zhang, Zhi Chen

“…However, the exact roles of PCSK9 in the pathogenesis of sepsis are still not well defined. In this review, we summarized the literatures focusing on the roles of PCSK9 in sepsis. …”
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Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population by Yue-miao Zhang, Xu-jie Zhou, Fa-juan Cheng, Yuan-yuan Qi, Ping Hou, Ming-hui Zhao, Hong Zhang

“…This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE.…”
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…The aim of this study was to provide a new understanding of the pathogenesis of disease and potential treatment targets for patients with PAH based on multiple-microarray analysis.Two microarray datasets (GSE53408 and GSE113439) downloaded from the Gene Expression Omnibus (GEO) database were analysed. …”
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Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria by Jinyun Chen, Qian Wang, Xuebing Feng, Zhuoya Zhang, Linyu Geng, Ting Xu, Dandan Wang, Lingyun Sun

“…Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). …”
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Maternal Circulating Concentrations of Tumor Necrosis Factor-Alpha, Leptin, and Adiponectin in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis by Jie Xu, Yan Hong Zhao, Yun Ping Chen, Xiao Lei Yuan, Jiao Wang, Hui Zhu, Chun Mei Lu

“…Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. …”
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RETRACTED ARTICLE: Screening and identification of susceptibility genes for cervical cancer via bioinformatics analysis and the construction of an mitophagy-related genes diagnosti... by Zhang Zhang, Fangfang Chen, Xiaoxiao Deng

“…The objective is to increase the understanding of the disease’s pathogenesis and improve early diagnosis and treatment. …”
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Congenital malformations in children of diabetic mothers in the province of Cienfuegos. 2016-2019 by Fanny Arbolay Sanabria, Lázaro Roberto Herrera Fragoso, Maylé Santos Solí, Gladys Bárbara Barberis Pérez, Walkiria Díaz Senra, María Soledad Vilches León

“…<p><strong>Foundation:</strong> the relationship between developmental alterations and poor glucose control in the pathogenesis of congenital malformations has been demonstrated.…”
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Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives by Makoto Naganuma, Mitsuhiro Takeno, Aykut Ferhat Çelik, Robert Moots, Philippe Pinton, Tadakazu Hisamatsu

“…., intestinal perforation) are among the primary causes of morbidity and mortality. GIBD pathogenesis involves the enhanced production of certain cytokines, e.g., tumor necrosis factor α and interleukin-6 (IL-6), which could serve as a target for potential therapies. …”
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Clinico-epidemiology and aetiopathogenesis of gallstone disease in the South Asian region: a scoping review protocol by Harshi Weerakoon, Ishari Vithanage, Oshadhi Alahakoon, Kosala Weerakoon

“…Introduction Pathogenesis of gallstones (GS) is multifactorial and is influenced by numerous environmental and genetic risk factors. …”
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