The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease by Qiuyu Yan, Wenhui Zhai, Chenghao Yang, Zihao Li, Longfei Mao, Mingyi Zhao, Xiushan Wu

“…The major metabolites of the GM influence pathogenesis of CVDs through various pathways. However, the relationship between PA and GM is less well understood. …”
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Oxidative Stress and Its Association with COVID-19: A Narrative Review by Hardi Rafat Baqi, Halgord Ali M. Farag, Abdel Hamid H. El Bilbeisi, Rafee Habib Askandar, Amany M. El Afifi

“…Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. …”
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Exploring the role of Microbiome in Susceptibility, Treatment Response and Outcome among Tuberculosis Patients from Pakistan: study protocol for a prospective cohort study (Micro-S... by Zia Ul-Haq, Muhammad Shahzad, Simon C Andrews

“…The protocol described in the current study aims to identify microbiome (oral and gut) signatures associated with TB pathogenesis, treatment response and outcome in humans.Methods and analysis Four hundred and fifty, newly diagnosed patients with TB from three district levels (Peshawar, Mardan and Swat) TB diagnosis and treatment centres, will be recruited in this non-interventional, prospective cohort study and will be followed and monitored until treatment completion. …”
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A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency... by Eman Tariq Ali, Azza Sajed Jabbar, Ali Nazar Mohammed

“…Interleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it. …”
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Characterization of Site-Specific Phosphorylation of NF-κB p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization by Haoshen Shi, Elizabeth A. Berger

“…Inflammation is an important contributor to the pathogenesis of diabetic retinopathy (DR). NF-κB is a master transcriptional regulator for numerous inflammatory genes. …”
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Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans by Zeinab Razooqi, Nabil Khzam, Nabil Khzam, Mahina L’Hostis, Georgios N. Belibasakis, Anders Johansson, Jan Oscarsson

“…This emphasizes that F. alocis and its ftxA are involved in the pathogenesis of periodontitis and may have ecological roles, with diagnostic and prognostic implications for the disease.…”
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Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration by Xiao Yu, Xiaopeng Zhang, Hazrat Bilal, Chang Shi, Lei Sun

“…Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing the interplay between circadian rhythm-related gene expression and immune infiltration identify highly specific diagnostic biomarkers for AMI. …”
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Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma by Lingling Li, Xiaocui Bu, Shuhui Wang, Yan Liu, Chongdao Chen, Wei Zhang, Peng Zhao

“…It has been well established that tumor-infiltrating lymphocytes (TILs) play a critical role in the pathogenesis and progression of clear cell renal cell carcinoma (ccRCC). …”
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Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior by M. Leo, M. Schulte, L.-I. Schmitt, M. Schäfers, C. Kleinschnitz, T. Hagenacker

“…TRPV1 is known to play an important role in the pathogenesis of inflammatory and neuropathic pain states. …”
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Unmet needs in atopic dermatitis management: an expert consensus by Annalisa Patrizi, Antonio Costanzo, Cataldo Patruno, Valentina Maria Busà, Andrea Chiricozzi, Giampiero Girolomoni

“…Although considerable advances have been made in understanding the pathogenesis and its treatment, there is still limited transfer of this knowledge into daily management. …”
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Evaluation of Serum D-dimer Levels and the Disease Severity in Patients of Chronic Urticaria by Leelavathy Budamakuntla, Sachin Somashekar, Heera Ramesh, Tapasya S Kini, S Nandish Kumar

“…Besides autoimmunity, the coagulation pathway is also involved in the pathogenesis of chronic urticaria (CU). Previous studies showed that plasma D-dimer levels paralleled the severity of the disease. …”
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Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes? by Cai-Guo Yu, Ning Zhang, Sha-Sha Yuan, Yan Ma, Long-Yan Yang, Ying-Mei Feng, Dong Zhao

“…However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating the uncertain role of EPCs in the pathogenesis of diabetic microvascular disease. In this review, we first illustrate how hyperglycemia induces metabolic and epigenetic changes in EPCs, which exerts deleterious impact on their number and function. …”
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Endoplasmic Reticulum Stress in Systemic Lupus Erythematosus and Lupus Nephritis: Potential Therapeutic Target by Hui-Yuan Li, Li-Feng Huang, Xiao-Rong Huang, Dan Wu, Xiao-Cui Chen, Ji-Xin Tang, Ning An, Hua-Feng Liu, Chen Yang

“…Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. …”
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The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing by Ping Sun, Zhiyong Guo, Daiping Guo, Jian Wang, Tingting Wu, Tingjun Li, Jiannan Liu, Xinhua Liu

“…This study offered insights into the pathogenesis of retrograde pulpitis.…”
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Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy by Chao Chen, Lirong Tan, Wu Zhu, Li Lei, Yehong Kuang, Panpan Liu, Jie Li, Xiang Chen, Cong Peng

“…However, the role of MDSCs in the pathogenesis of psoriasis remains unclear. Here, we confirmed that the accumulation of human MDSCs is remarkably increased in skin lesions of psoriasis patients by flow cytometry. …”
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Transmembrane and Ubiquitin-Like Domain-Containing 1 Promotes Glioma Growth and Indicates Unfavorable Prognosis by Yinggang Liu, Changcheng Cai, Ke Wu, Libo Hu

“…This study contributes valuable insights into the multifaceted role of TMUB1 in glioma pathogenesis and its potential as a diagnostic and therapeutic target.…”
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Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis by Simone Filardo, Marisa Di Pietro, Alessio Farcomeni, Giovanna Schiavoni, Rosa Sessa

“…Therefore, we performed a meta-analysis to clarify whether C. pneumoniae may contribute to the pathogenesis of atherosclerosis by enhancing inflammation. 12 case-control, 6 cross-sectional, and 7 prospective studies with a total of 10,176 patients have been included in this meta-analysis. …”
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In Vivo and Cadaver Studies of the Canalicular/Lacrimal Sac Mucosal Folds by Yongsheng You, Jing Cao, Xiaogang Zhang, Wencan Wu, Tianlin Xiao, Yunhai Tu

“…They may be involved in the drainage of tears or the pathogenesis of acute dacryocystitis or lacrimal sac mucocele.…”
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Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. …”
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High-Salt Enhances the Inflammatory Response by Retina Pigment Epithelium Cells following Lipopolysaccharide Stimulation by Dike Zhang, Chaokui Wang, Shuang Cao, Zi Ye, Bolin Deng, Aize Kijlstra, Peizeng Yang

“…High-salt has been shown to play a role in the pathogenesis of autoimmune disease. In this study, we investigated the effect of high-salt on the production of inflammatory mediators by ARPE-19 cells and the possible mechanisms involved. …”
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