Value of Biochemical Indexes of Bone Metabolism in Predicting Osteoporotic Lumbar Fractures by Fen Feng, CiLa Zhou, Ping Huang, QiaoLin Zhu, Gang Wang, Bin Zhou

“…Moreover, the levels of P1NP, 25(OH)D, OSTEOC, and PTH are important factors affecting the pathogenesis of osteoporosis. The area under the curve (AUC) of fracture in patients with osteoporosis predicted by the combination of P1NP, 25(OH)D, OSTEOC, and PTH levels was 0.886, which was greater than the AUC predicted by each index (0.796, 0.753, 0.670, and 0.824). …”
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An autopsy case with tubular obstruction by impacted swollen blebs due to ischemic acute kidney injury by Yukako Akiyama, Mitsuhiro Sato, Yoshio Taguma

“…Conclusion Our distinct finding of bleb formation with tubular obstruction strongly indicates that blebbing could be related to the mechanism of oliguric AKI in human, which supports the tubular obstruction theory as a contributing factor to the pathogenesis of ischemic AKI.…”
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Efficacy And Safety Of Low Dose Tofacitinib As Induction Therapy In Moderate To Severe Ulcerative Colitis: A Pilot Study by Sadia Ahmed, Muhammad Umar, Muhammad Kamran, Misbah Noureen, Iqra Ashraf, Javeria Khan

“… Objective: The Inflammatory cascade has been the root cause of ulcerative colitis's pathogenesis, and its treatment would centre upon reducing its intensity. …”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…By analyzing their relevant roles in the pathogenesis of the two ALL forms, new molecular mechanisms able to modulate cancer cell invasion may be visualized. …”
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Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis by Li Zhang, Xiaoyu Fang, Suhua Wang, Shasha Ma, Jinyan Zhang, Xiang Dong, Jing Dai, Chuanmiao Liu, Yu Gao

“…In summary, this study identified differentially expressed mRNAs (DE-mRNAs) and DE-lncRNAs and predicted the biological processes and signaling pathways involved in cirrhotic decompensation, which might provide new ideas for further revealing the molecular mechanism of DCC pathogenesis.…”
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Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, T. L. Lapina, A. S. Trukhmanov, I. M. Kartavenko, V. A. Kiprianis, O. Z. Okhlobystina

“…To present the modern concept on etiology and pathogenesis of functional dyspepsia (FD) to general practitioners, as well as with the accepted approach to diagnostics and treatment of this disease. …”
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Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain by Cui Yan Lu, De Xiang Liu, Hong Jiang, Fang Pan, Cyrus S. H. Ho, Roger C. M. Ho

“…We aimed to observe the role of GABAAR subunits changes induced by juvenile trauma in the pathogenesis of subsequent PTSD in adulthood. In addition, we investigated the protective effects of exercise for 6 weeks and benzodiazepine (clonazepam) for 2 weeks. …”
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Single-cell transcriptomes reveal cell-type-specific and sample-specific gene function in human cancer by Huating Yuan, Xin Liang, Xinxin Zhang, Yu Cao

“…Accurate annotation of gene function in individual samples and even in each cell type is essential for understanding the pathogenesis of cancers. Single-cell RNA-sequencing (scRNA-seq) provides unprecedented resolution to decipher gene function. …”
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Unusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review by Gao A, Tian X, Lang D, Chen Y

“…Despite established diagnostic criteria for SM, its pathogenesis remains poorly understood. Chronic antigenic stimulation from circulating cytokines and viral infections, such as HBV, may contribute to disease development. …”
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MicroRNAs in Autoimmune Sjögren’s Syndrome by Seunghee Cha, Mahmoud Mona, Kyung Eun Lee, Dong Hee Kim, Kyudong Han

“…This review compiles and highlights differentially-expressed miRNAs in various samples collected from SjS patients and their potential implications in the pathogenesis of SjS. To facilitate the development of miRNA-targeted personalized therapy in the future, we urge more follow-up studies that confirm these findings and elucidate the immunopathological roles of differentially-expressed miRNAs. …”
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Analysis of the Cytokine Expression in the Aqueous Humor of Individuals with BRVO-Associated Macular Edema by Chengyi Zhu, Lanlan Pan, Qiong Yi, Qiping Wei

“…Therefore, an in-depth study of the levels and the relationship may provide some evidence for the pathogenesis, treatment, and prevention of BRVO-ME.…”
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Role of S100 Proteins in Colorectal Carcinogenesis by Paula Moravkova, Darina Kohoutova, Stanislav Rejchrt, Jiri Cyrany, Jan Bures

“…S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activate NF-κβ signaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. …”
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Pure Testicular Seminoma Relapsing Late with Somatic Type Malignancy by Klaus-Peter Dieckmann, Petra Anheuser, Ralf Gehrckens, Waldemar Wilczak, Guido Sauter, Doris Höflmayer

“…The patient is well 1 year after surgery. Conclusion. The pathogenesis of this STM remains enigmatic. The origin from GCT was evidenced by documentation of isochromosome 12p. …”
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A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy by Pingna Zhang, Weijun Huang, Qiyan Zheng, Jingyi Tang, Zhaocheng Dong, Yuhua Jiang, Yuning Liu, Weijing Liu

“…However, the factors triggering autoantibody production as well as the association among air pollution, malignancy, and the pathogenesis of MN remain unclear. In this review, we discuss the similarity between the pathological mechanisms triggered by disparate antigens and their associated diseases. …”
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A database on genes increasing resistance of wheat and relative species against pathogenic fungi by O. G. Smirnova, A. V. Kochetov

“…In this paper we present an information resource for accumulation of data on sequenced genes of wheat and its relatives providing resistance against diseases caused by fungal pathogens. The database (Pathogenesis-Related Genes, PRG) contains information on gene chromosomal localizations and functional activities, nucleotide sequences and single nucleotide polymorphisms associated with their effects. …”
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Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models by Xueli Fan, Chenhong Lin, Jinming Han, Xinmei Jiang, Jie Zhu, Tao Jin

“…Emerging data have shown that TFH cells and TFH-associated molecules may be involved in the pathogenesis of neuroautoimmune diseases including multiple sclerosis (MS), neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorders (NMOSD), and myasthenia gravis (MG). …”
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HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response by Mudan Lu, Shanshan Yu, Wei Xu, Bo Gao, Sidong Xiong

“…HMGB1, which may act as a proinflammatory mediator, has been proposed to contribute to the pathogenesis of multiple chronic inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE); however, the precise mechanism of HMGB1 in the pathogenic process of SLE remains obscure. …”
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Investigating causal relationship among inflammatory cytokines and oropharyngeal cancer: Mendelian randomization by Sibo Xu, Yiguo Li, Wei Chen, Ke Wang

“…Conclusion This investigation posits that IL-5 and IL-7 may be pertinent factors in the etiology of Oropharyngeal cancer, while PDGF bb and CTACK are likely implicated in the pathogenesis of both oral and oropharyngeal cancers.…”
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Understanding the pros and cons of spine surgery for ankylosing spondylitis: experience from a single institution study by Mohammadreza Chehrassan, Mohammadreza Shakeri, Farshad Nikouei, Saeed Sabbaghan, Behnam Sour, Ebrahim Ameri Mahabadi, Hasan Ghandhari

“…Despite advancements in understanding its pathogenesis, comprehensive elucidation remains elusive. …”
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15q23 Gain in a Neonate with a Giant Omphalocele and Multiple Co-Occurring Anomalies by Hui-Fang Zhou, Christopher J. O’Conor, Chiraag Gangahar, Louis P. Dehner

“…Newer techniques such as high-resolution microarray analysis allow for the study of alterations in chromosomal segments that are less than 5 Mb in length; this has led to identification of critical region and genes in the pathogenesis of omphalocele. Case Presentation. The current study is the initial report of a newborn male with a 15q23 gain and a giant omphalocele. …”
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