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1621
Aging-associated sensory decline and Alzheimer’s disease
Published 2024-12-01“…Recent studies have begun to shed light on the possibility that age-related sensory decline could accelerate AD pathogenesis, or be a prodromal indicator of AD. Sensory impairments, specifically in taste and smell, often emerge before cognitive symptoms in AD, indicating their potential as early biomarkers. …”
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1622
Cytokines and Other Mediators in Alopecia Areata
Published 2010-01-01“…So far, IFN-𝛾, interleukins, TNF-𝛼, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. …”
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1623
Cytokine changes in patients with heatstroke during pilgrimage to Makkah
Published 1997-01-01“…The study demonstrated the elevation of the above mediators and suggested a role in the pathogenesis of heatstroke. Markedly elevated levels or those that remained elevated despite cooling were associated with mortality.…”
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1624
The role of immunity in insulin resistance in patients with polycystic ovary syndrome
Published 2025-01-01“…While the precise pathogenesis of PCOS remains unclear, it is now recognized that genetic, endocrine, and metabolic dysregulations all contribute significantly to its onset. …”
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1625
PTCH1 mutations' role in keratocystic odontogenic tumors and nevoid basal cell carcinoma syndrome
Published 2024-06-01“…The function of PTCH1 mutations in the pathogenesis of KOTs is the subject of this study, which compares cases associated with NBCCS and spontaneous KOTs. …”
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1626
Pest Status of Subfamily Lymantriinae (Lepidoptera: Erebidae: Noctuoidea): Review
Published 2024-04-01“…They act as a threat to the crops through various mechanisms of pathogenesis that compromise the immune system of the plants, such as developing any ways to attack the plants, seeking entry via open pores or exposed surface or wound, and sourcing nutrients forcefully for their growth and development. …”
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1627
Kidney Stone Disease: An Update on Current Concepts
Published 2018-01-01“…Therefore, this review has intended to provide a compiled up-to-date information on kidney stone etiology, pathogenesis, and prevention approaches.…”
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1628
Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection
Published 2025-12-01“…A detailed exploration of the genetic basis for GBS pathogenicity follows, emphasizing the roles of capsules in pathogenesis and immune evasion. The paper also examines the molecular structures and functions of key GBS surface proteins, such as pili, serine-rich repeat proteins, and fibrinogen-binding proteins, which facilitate colonization and disease. …”
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1629
CTRP9 Mitigates the Progression of Arteriovenous Shunt-Induced Pulmonary Artery Hypertension in Rats
Published 2021-01-01“…These findings suggest a previously unrecognized effect of CTRP9 in pulmonary vascular homeostasis during PAH pathogenesis.…”
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1630
Aquaporin-2 in the early stages of the adenine-induced chronic kidney disease model.
Published 2025-01-01“…However, the molecular mechanisms involved in the pathogenesis of this condition and its progression still are not entirely understood. …”
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1631
Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection
Published 2025-01-01“…To better understand the factors involved in viral infection and pathogenesis and to develop novel therapies, it is crucial to investigate virus–host interactions. …”
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1632
Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain
Published 2013-01-01“…This review will focus on how cytokines and chemokines affect neuroinflammation and disease pathogenesis in bacterial meningitis and brain abscesses, Lyme neuroborreliosis, human immunodeficiency virus encephalitis, and neuropathic pain.…”
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1633
The Immune Response and Its Therapeutic Modulation in Bronchiectasis
Published 2012-01-01“…Thus, the outcome of an active immune response as detrimental or protective in the pathogenesis of BC may be dependent on the state of the patient's immunity, the severity of infection, and the magnitude of immune response. …”
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1634
Maxillary osteonecrosis linked to Pembrolizumab therapy: a case report
Published 2024-01-01“…Conclusion: While definitive causality between Pembrolizumab and osteonecrosis of the jaw cannot be established with the current evidence, this case adds to the growing body of literature suggesting that immune checkpoint inhibitors may be implicated in the pathogenesis of osteonecrosis of the jaw. As the use of immunotherapy expands in oncology, further research is essential to elucidate this association and provide guidelines.…”
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1635
Rat models of frozen shoulder: Classification and evaluation
Published 2025-01-01“…Therefore, it is necessary to develop and utilize animal models to understand the pathogenesis of FS and to explore treatment strategies, providing insights into the prevention and treatment of human FS. …”
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1636
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives
Published 2019-01-01“…Hematologic malignancy risk in AAV is more likely to be increased by cyclophosphamide, although not yet definitely proven. Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation. …”
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1637
Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function
Published 2025-06-01“…Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monitor the course of the disease. …”
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1638
Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis
Published 2020-01-01“…Osteoarthritis (OA) has long been considered as a degenerative disease, but growing evidence suggests that inflammation plays a vital role in its pathogenesis. Unlike rheumatoid arthritis and other autoimmune diseases, inflammation in OA is chronic and, in relatively low grade, mainly mediated by the innate immune system, especially macrophages. …”
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1639
Genomic Research to Identify Novel Pathways in the Development of Abdominal Aortic Aneurysm
Published 2012-01-01“…There is a need to improve our understanding of AAA pathogenesis in order to develop novel treatment paradigms. …”
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1640
The significance of antibody to hepatitis B surface antigen in infection and clearance of hepatitis B virus
Published 2025-12-01“…Recent studies on HBV-specific B cells and antibody to hepatitis B surface antigen (anti-HBs) have shed light on their role in the pathogenesis of chronic hepatitis B (CHB). Anti-HBs is recognized as a protective immune marker, both for HBV infection clearance and following vaccination, and it is also considered an important indicator of functional cure for CHB. …”
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