Efficacy and Safety of Rituximab in the Treatment of Idiopathic Membranous Nephropathy: A Meta-Analysis by Huijuan Lu, Jun Shen, Jieqiong Sun, Jia Sun

“…Primary membranous nephropathy (MN), sometimes referred to as idiopathic membranous nephropathy (IMN), is a kind of MN whose pathogenesis is yet unclear. According to research reports, the incidence of IMN is about 9.8–26.8%, and it is on the rise. …”
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Sympathoexcitation Associated with Renin-Angiotensin System in Metabolic Syndrome by Takuya Kishi, Yoshitaka Hirooka

“…Although RAS activation is important for the therapeutic target, underlying sympathetic nervous system (SNS) activation is critically involved and should not be neglected in the pathogenesis of hypertension with MetS. In fact, previous studies have suggested that SNS activation has the interaction with RAS activation and/or insulin resistance. …”
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The overview of modern approaches in treatment of triple negative breast cancer by A. A. Kharitonova, I. A. Smirnova, M. V. Kiseleva

“…The purpose of this review is to analyze current ideas about the pathogenesis, clinical characteristics of different subtypes of triple negative breast cancer, the nature of its metastasis, mechanisms of chemoresistance. …”
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Animal Models of Diabetes-Associated Renal Injury by Zahra Samadi Noshahr, Hossein Salmani, Abolfazl Khajavi Rad, Amirhossein Sahebkar

“…Many rodent models of type 1 and type 2 diabetes have been established to elucidate the pathogenesis of diabetes and examine novel therapies against DN. …”
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Extracellular vesicles in thalassemia: Mechanisms, implications, and therapeutic potential by Shahzad Ali Jiskani

“…The current review aims to examine the role of EVs in the pathogenesis of thalassemia, their implications, and their potential clinical applications. …”
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Clinical Relevance of HLA Gene Variants in HBV Infection by Li Wang, Zhi-Qiang Zou, Kai Wang

“…A better understanding of HLA polymorphism relevance in HBV infection outcome would enable us to elucidate the roles of HLA SNPs in the pathogenesis and clearance of HBV in different areas and ethnic groups, to improve strategies for the prevention and treatment of chronic HBV infection.…”
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COVID-19 and post-disease features in patients with obesity by Ekaterina S. Frolova, Pavel P. Veselovsky, Galina A. Chumakova, Nadezhda G. Veselovskaya, Anna V. Ott

“…Many countries were forced to promptly reorganize their healthcare system in order to save patients with COVID-19. The pathogenesis and specifics of the disease are not completely understood, but one pattern is particularly clear: COVID-19 tends to be more severe in people with obesity. …”
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Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia by Keiko Ikemoto, Tatsuro Oda, Akiyoshi Nishimura, Katsuji Nishi

“…The mesolimbic dopamine (DA) system has been associated with the pathogenesis of schizophrenia. Here, we examined DA-containing neuronal structures of the ventral tegmental area (VTA) of an autopsy case of disorganized type of schizophrenia (75-year-old female), using tyrosine hydroxylase (TH) immunohistochemistry. …”
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A Rare Case of Septic Shock Secondary to Emphysematous Hepatitis by Khaled M. Nada, Ibrahim El Husseini, Mohammad E. Abu Hishmeh, Neerav S. Shah, Nadezhda Ibragimova, Riyad Basir

“…Relevant literature was reviewed and, to the best of our knowledge, there is limited data regarding the pathogenesis, causative organisms, and management of this condition. …”
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Vesicles Generated during Storage of Red Blood Cells Enhance the Generation of Radical Oxygen Speciesin Activated Neutrophils by Herbert Jank, Ulrich Salzer

“…The activating effect of Vsto vesicles on neutrophils might be due to the specific accumulation of lysophospholipidsin Vsto vesicles and should be considered as a possible contributor to the pathogenesis of transfusion-related acute lung injury.…”
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Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population by Angharad R. Morgan, Wen-Jiun Lam, Dug-Yeo Han, Alan G. Fraser, Lynnette R. Ferguson

“…A recent study provided evidence for the involvement of ULK1 in the pathogenesis of CD (Henckaerts et al., 2011). We attempted to validate this association, using a candidate gene SNP study of ULK1 in CD. …”
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Natural Catalytic Antibodies in Norm, Autoimmune, Viral, and Bacterial Diseases by Georgy A. Nevinsky, Valentina N. Buneva

“…Some Abzs are cytotoxic and can play an important negative role in the pathogenesis of ADs, while positive roles have been proposed for other Abzs. …”
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Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer by Ge Cong, Xingyu Zhu, Xin Ru Chen, Hao Chen, Wei Chong

“…The hedgehog signaling pathway, a critical mediator in the normal development of numerous organs and the pathogenesis of cancer, is typically quiescent but is aberrantly activated in several malignancies. …”
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Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. by Haleema Sadia Malik, James B Bliska

“…Virulent microbes produce proteins that interact with host cell targets to promote pathogenesis. For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. …”
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Immunological responses in patients with tuberculosis and in vivo effects of acetyl-L-carnitine oral administration by Emilio Jirillo, Maria Altamura, Carlo Marcuccio, Cosimo Tortorella, Claudio De Simone, Salvatore Antonaci

“…This cytokine plays a detrimental rather than beneficial role in TBC pathogenesis. In the light of these data, ALC seems to be a powerful immunomodulator in the course of Mycobacterium tuberculosis infection and other mycobacteriosis.…”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Meanwhile, oligodendrocytes, primarily involved in myelination, also modulate axonal excitability and contribute to the neuron–glia network underlying seizure pathogenesis. Understanding the dynamic interactions of glial cells with neurons provides promising avenues for novel epilepsy therapies. …”
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Role of dietary and nutritional interventions in ceramide-associated diseases by Shengnan Wang, Zihui Jin, Biyu Wu, Andrew J. Morris, Pan Deng

“…This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.…”
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Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission by Mário A. C. Silva-Neto, Alan B. Carneiro, Livia Silva-Cardoso, Georgia C. Atella

“…In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.…”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Understanding the mechanisms of host–pathogen interaction, host immunity, viral immune evasion, and disease pathogenesis is highly warranted to foster the development of antivirals. …”
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Forward programming of hPSCs to neutrophils using chemically defined media by Hayley E. Hall, Xiaoping Bao, Cheng Dong, Xiaojun Lance Lian

“…In recent years, PMNs have gained increasing recognition for their significant involvement in the pathogenesis of a wide array of human diseases, including sepsis, pulmonary conditions, autoimmune disorders, and various cancers. …”
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