Human Oral Keratinocytes Challenged by Streptococcus sanguinis and Porphyromonas gingivalis Differentially Affect the Chemotactic Activity of THP-1 Monocytes by Huajing Li, Chaminda Jayampath Seneviratne, Lijian Jin

“…The current findings on P. gingivalis-HOKs interactions with resultant paralysis of THP-1 cell chemotaxis provide further evidence that the keystone periodontopathogen P. gingivalis can evade innate defense and contribute to periodontal pathogenesis.…”
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Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study by Zhongwen Jia, Lihan Tang, Jidong Lv, Linhong Deng, Ling Zou

“…These findings suggest that altered information flow in the brains of depressed patients is related to the pathogenesis of depression, providing insights for patient identification and pathological studies.…”
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Pathology of the Gastrointestinal Tract in Patients with Primary Hyperparathyroidism by I. A. Baranova, A. V. Baranov

“…To present data of Russian and foreign studies on the prevalence, pathogenesis and clinical picture of gastrointestinal tract (GIT) pathology in patients with primary hyperparathyroidism (PHPT).Key point. …”
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Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I by Kai Sun, Richard D. Semba, Linda P. Fried, Debra A. Schaumberg, Luigi Ferrucci, Ravi Varadhan

“…Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). …”
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Tension Pneumatocele due to Enterobacter gergoviae Pneumonia: A Case Report by Emeka B. Kesieme, Chinenye N. Kesieme, George O. Akpede, Kelechi E. Okonta, Andrew E. Dongo, Adewuyi M. Gbolagade, Sylvester U. Eluehike

“…Many organisms have been implicated in the pathogenesis of this disease; however, this is the first report of tension pneumatocele resulting from Enterobacter gergoviae pneumonia. …”
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Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 by Omar Ramos-Lopez, Lidia Daimiel, Ana Ramírez de Molina, Diego Martínez-Urbistondo, Juan A. Vargas, J. Alfredo Martínez

“…Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.…”
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The Chemical Composition of Endotoxin Isolated from Intestinal Strain of Desulfovibrio desulfuricans by Jolanta Lodowska, Daniel Wolny, Marzena Jaworska-Kik, Sławomir Kurkiewicz, Zofia Dzierżewicz, Ludmiła Węglarz

“…There are suggestions that they take part in the pathogenesis of periodontitis and some gastrointestinal inflammatory disorders, such as ulcerative colitis or Crohn’s disease. …”
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A cross-tissue transcriptome-wide association study identified susceptibility genes for age-related macular degeneration by Hongfan Yang, Haofei Huang, Kunlin Pu

“…Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in the pathogenesis of AMD and to elucidate their functional mechanisms. …”
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Serum Level of the Angiotensin-Converting Enzyme in Patients with Idiopathic Acute Optic Neuritis: A Case-Control Study by Heshmatollah Ghanbari, Alireza Dehghani, Awat Feizi, Arman Amirkhani, Mohsen Pourazizi

“…To evaluate the serum level of angiotensin-converting enzyme (ACE) as an important component of the renin-angiotensin system (RAS) in optic neuritis (ON) compared to the healthy control group in the context investigating the possible role of ACE in ON pathogenesis. Methods. This case-control study was conducted on patients with ON and healthy controls. …”
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Exploration on Molecular Mechanism of Reversal Effect of Compound Danshen Tablets on Hepatic Fibrosis Based on Network Pharmacology by Minling Cao, Jingyue Fan, Xiaoli Yang, Meifeng Shi, Shanshan Lin, Xiaoling Chi

“…TNF, IL-10, TGF-1, and EGF and FOXO and MAPK signaling pathways play a key role in the pathogenesis of hepatic fibrosis. Based on the results of this study, the mechanism of action of compound Danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of FoxO and MAPK signaling pathways and inhibition of TNF, IL-10, TGF-1, and EGF.…”
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Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis by Kazuhiko Umazume, Jun Suzuki, Yoshihiko Usui, Yoshihiro Wakabayashi, Hiroshi Goto

“…PVD may be related to the pathogenesis and aggravation of EE.…”
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Self-Centered Function of Adaptive Immunity in Regulation of Immune Responses and in Tolerance by Silvana Balzar

“…The search for common mechanisms underlying the pathogenesis of chronic inflammatory conditions has crystalized the concept of continuous dual resetting of the immune repertoire (CDR) as a basic principle of the immune system function. …”
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The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma by Junying Lu, Lingxin Xiong, Xiaohao Zhang, Zhongmin Liu, Shiji Wang, Chao Zhang, Jingtong Zheng, Guoqiang Wang, Ruipeng Zheng, Jodie L. Simpson, Fang Wang

“…To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis.…”
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Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons by Simone Hagmeyer, Katharina Mangus, Tobias M. Boeckers, Andreas M. Grabrucker

“…Various recent studies revealed that biometal dyshomeostasis plays a crucial role in the pathogenesis of neurological disorders such as autism spectrum disorders (ASD). …”
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G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells by Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge

“…Modulation of the cell cycle of host cells is likely to contribute to the pathogenesis of meningococcal disease.…”
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Overexpression of SFPQ Improves Cognition and Memory in AD Mice by Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

“…Alzheimer’s disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis, which has been extensively investigated, yet effective treatments remain lacking. …”
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Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…In this paper, the effects of LA on RA pathogenesis will be summarized from the perspective of the production, transport, and metabolism of synoviocytes and immune cells. …”
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Potential Role of Caveolin-1 in Regulating the Function of Endothelial Progenitor Cells from Experimental MODS Model by Tianhang Luo, Jixin Shu, Zhengmao Lu, Ting Han, Guoen Fang, Xuchao Xue

“…It is unclear whether and how caveolin-1 (Cav-1) in EPCs contributes to the pathogenesis of MODS. The present study is aimed at investigating the potential role of Cav-1 in EPCs during MODS. …”
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Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. …”
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Microbial Translocation in Chronic Liver Diseases by Marilia Rita Pinzone, Benedetto Maurizio Celesia, Michele Di Rosa, Bruno Cacopardo, Giuseppe Nunnari

“…Furthermore, MT has been implicated in the pathogenesis of the complications of cirrhosis, which are a significant cause of morbidity and mortality in cirrhotic subjects. …”
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