Spines, Plasticity, and Cognition in Alzheimer's Model Mice by Tara Spires-Jones, Shira Knafo

“…Together, these data support a model of AD pathogenesis in which soluble Aβ initiates synaptic dysfunction and loss, as well as pathological changes in tau, which contribute to both synaptic and neuronal loss. …”
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Nutritional Factors Related to Canine Gallbladder Diseases—A Scoping Review by Fabio Alves Teixeira, Kathleen Moira Aicher, Ricardo Duarte

“…This paper provides a review of the literature about possible nutritional factors involved in the pathogenesis and treatment of canine gallbladder mucocele and cholelithiasis. …”
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The deregulated physiology in oral squamous cell carcinoma- a brief review by Keerthika Saravanan, Madhu Narayan, Krishnan Rajkumar

“…Not only the disease but also its treatment ravages a patient afflicted with it. Decoding its pathogenesis in entirety and the process through which it is able to not only survive but also grow indefinitely despite the inherent immune mechanisms of the human body is an area of continuous research. …”
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Evaluation and Interpretation of Transcriptome Data Underlying Heterogeneous Chronic Obstructive Pulmonary Disease by Seokjin Ham, Yeon-Mok Oh, Tae-Young Roh

“…Our extensive evaluation of COPD transcriptome data could provide guidelines for analyzing heterogeneous gene expression profiles and classifying potential candidate genes that are responsible for the pathogenesis of COPD.…”
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Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease by Linyu Wu, Xiaohui Xian, Guangyu Xu, Zixuan Tan, Fang Dong, Min Zhang, Feng Zhang

“…This article reviews the role of TLR4 in the pathogenesis of AD and a range of potential therapies targeting TLR4 for AD. …”
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Mandibular Canal Widening and Bell’s Palsy: Sequelae of Perineural Invasion in Oral Cancer by Gopinath Thilak Parepady Sundar, Vishwanath Sherigar, Sameep S. Shetty, Shree Satya, Sourabh M. Gohil

“…The objective of this case report is to enumerate the significance of perineural invasion in determining the course of the disease and necessitate the need for future studies that can shed light on molecular mediators and pathogenesis of perineural spread.…”
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Ferritin in Adult-Onset Still’s Disease: Just a Useful Innocent Bystander? by Bella Mehta, Petros Efthimiou

“…Regulation by proinflammatory cytokines such as interleukin (IL)-1b, IL-6, IL-18, MCSF, and INF-α provides a link to the disease pathogenesis and may explain rapid resolution of hyperferritinemia after targeted treatment and inhibition of key cytokines.…”
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The Role of the NIS (SLC5A5) Gene in Papillary Thyroid Cancer: A Systematic Review by Rafael Martins de Morais, Alaor Barra Sobrinho, Calliandra Maria de Souza Silva, Jamila Reis de Oliveira, Izabel Cristina Rodrigues da Silva, Otávio de Toledo Nóbrega

“…Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.…”
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Kidney and Urinary Tract Involvement in Kawasaki Disease by Toru Watanabe

“…Although the precise pathogenesis of KD is not completely understood, renal vasculitis, immune-complex mediated kidney injuries, or T-cell immune-regulatory abnormalities have been proposed as possible mechanisms for the development of kidney and urinary tract injuries.…”
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Inflammation in Diabetic Nephropathy by Andy K. H. Lim, Gregory H. Tesch

“…We also briefly discuss some of the major inflammatory cytokines involved in the pathogenesis of diabetic nephropathy, including the role of adipokines. …”
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The intestinal microbiome as a separate organ by Yu. O. Shulpekova

“…Due to difference in sampling methods it is difficult to draw clear-cut conclusions on microflora role in pathogenesis for scientific investigations. Analysis of sequential cloning of 16S ribosomal RNA possesses the highest information value of all up-to-date methods. …”
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COVID-19 Pandemic and Irritable Bowel Syndrome — is there a Relationship? by V. A. Akhmedov

“…These factors dictate the need for an integrated approach in the management of such a group of patients with the use of modern multi-target drugs that affect the pathogenetic factors in the formation of functional gastrointestinal diseases, one of which is the Kolofort drug due to the triple multi-target mechanism of action on the pathogenesis of functional gastrointestinal diseases.…”
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Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia by Sirilaksana Kunjara, Patricia McLean, Laurens Rademacher, Thomas W. Rademacher, Fabiana Fascilla, Stefano Bettocchi, Marco Scioscia

“…Endothelial cells hold the key role in the pathogenesis of this disease. The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism. …”
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A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease by Keynaz Keykavousi, Fahimeh Nourbakhsh, Nooshin Abdollahpour, Farzaneh Fazeli, Alireza Sedaghat, Vahid Soheili, Amirhossein Sahebkar

“…The purpose of this review is to investigate the role of hematological (white blood cell (WBC), lymphocyte, and neutrophil count, neutrophil-to-lymphocyte ratio (NLR), platelet, and red blood cell (RBC) count), inflammatory (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and lactate dehydrogenase (LDH)), and biochemical (Albumin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, D-dimer, total Cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)) biomarkers in the pathogenesis of COVID-19 disease and how their levels vary according to disease severity.…”
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Gut microbiota and blood biomarkers in IBD-Related arthritis: insights from mendelian randomization by Wei Yang, Miao Cui, Peng Yang, Chenlin Liu, Xiuzhen Han, Wenyi Yao, Zhenhua Li

“…This research offers a novel perspective for a deeper understanding of the pathogenesis of IBD-related arthritis and highlights future directions for the diagnosis and treatment strategies of this condition.…”
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Current trends in studying glaucoma: a review of published data by L.A. Zaporozhetc, V.N. Alekseev, E.A. Egorov, Е.В. Martynova, Yu.A. Alekseev

“…</i> </p> <p> <i><b>Conclusions</b>: primary studies on glaucoma are similar in Russia and foreign countries, i.e., theoretical aspects (etiology and pathogenesis) and improving surgical techniques. Our findings demonstrate a growing interest in a personalized approach to study glaucoma. …”
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Association of TNF-α gene promoter polymorphism with primary open-angle glaucoma by A.V. Shevchenko, V.F. Prokof’ev, V.I. Konenkov, A.V. Eremina, A.N. Trunov, V.V. Chernykh

“…</i> </p> <p> <i><b>Conclusion</b>: minor genotype TNF-308*АА is an essential factor of POAG pathogenesis. Two other polymorphic gene variants were associated with POAG as a part of complex genotypes. …”
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The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

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Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy by Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

“…However, the precise contribution of FGFR3 to the pathogenesis of HCH remains elusive. Methods: We generated an Fgfr3 (V376D) mutation mouse model using CRISPR/Cas9 technology and performed proteomic analyses to investigate the molecular mechanisms and potential therapeutic targets of HCH. …”
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Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia by Rong Lin, Rong Lin, XiaoYing Weng, XiaoYing Weng, Liang Lin, Liang Lin, XuYang Hu, XuYang Hu, ZhiYan Liu, ZhiYan Liu, Jing Zheng, Jing Zheng, FenFang Shen, FenFang Shen, Rui Li, Rui Li

“…BackgroundThe involvement of mitochondrial and programmed cell death (mtPCD)–related genes in the pathogenesis of pre-eclampsia (PE) remains inadequately characterized.MethodsThis study explores the role of mtPCD genes in PE through bioinformatics and experimental approaches. …”
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