Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis by Xiaoxu Zhou, Ping Shentu, Yingke Xu

“…Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.…”
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Biofilm Forming Intestinal Escherichia coli as a Risk Factor for Increasing BMI in Type 2 Diabetic Patients by Sahar Salih Hussein, Asal Aziz Tawfeeq

“…On the other hand, gut bacteria have a key role in the regulation of different metabolic pathways that are important in glucose homeostasis and diabetes type 2 pathogenesis. Objectives: This study aimed to analyze the effect certain gut and biofilm formation on the glucose homeostasis and BMI in diabetic females. …”
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Symphysis Pubis Osteomyelitis: An Uncommon Complication after Robotic Assisted Radical Prostatectomy—Case Description with Literature Review by Jad A. Degheili, Mazen M. Mansour, Rami W. Nasr

“…Other than the well-known surgical complications such as erectile dysfunction, urinary incontinence, and voiding dysfunction, osteomyelitis of the symphysis pubis is not a well-understood complication, with various hypotheses explaining its pathogenesis. Although osteomyelitis of the pubis symphysis has been reported after endoscopic urological procedures such as transurethral resection of the prostate, it has rarely been reported after robotic surgeries. …”
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A Case of a Nonpetrous Cholesterol Granuloma Presenting as a Temporal Mass by Nathaniel Reeve, Jacob Kahane, Matthew Ng

“…This case supports the theory of pathogenesis of such lesions typically occurring where pneumatized air spaces interface with bone marrow, in this case, where the reaches of pneumatized cells in the squamous portion of the temporal bone meet diploic bone.…”
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Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects by Feng Zhang, Zhuqing Li, Yanxin Wang, Chao Li, Chengzhi Lu

“…Recent studies have highlighted the crucial roles of mitochondrial dysfunction in the pathogenesis of DCM, including aspects such as glucose-lipid metabolic disorder, oxidative stress damage, calcium regulation disorder, respiratory chain uncoupling, kinetic imbalance, and mitochondrial DNA damage. …”
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Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family by Kyeongchae Cheong, Jaehyuk Choi, Jaeyoung Choi, Jongsun Park, Suwang Jang, Yong-Hwan Lee

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Gastro-intestinal involvement in systemic sclerosis by Saurabh Kedia, Anuj Chhaparia, Pramod Garg

“…Future research is needed in the pathogenesis, development of biomarkers for early identification of GI involvement at the asymptomatic stage, and targeted disease-modifying therapies, which can alter/halt the disease progression.…”
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Oxford-AstraZeneca Coronavirus Disease-2019 Vaccine-Induced Immune Thrombocytopenia on Day Two by Azhar Kareem Razzaq, Ameer Al-Jasim

“…Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by platelet damage, life-threatening thrombocytopenia, and haemorrhage when the platelet count reaches below 20 × 109/mcL. Its pathogenesis involves viral mimicry or T-cell-induced immune destruction in antibody-negative cases. …”
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Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports by Reda Laamech, Hamza Naciri-Bennani, Diane Giovannini, Johan Noble, Bénédicte Janbon, Paolo Malvezzi, Thomas Jouve, Lionel Rostaing

“…We report two cases of extremely rapid recurrent AAV after renal transplantation; both were still ANCA-positive at the time of transplantation, which led us to question the pathogenesis of ANCA antibodies in recurrence in a kidney allograft. …”
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Systemic Inflammation and Acute-on-Chronic Liver Failure: Too Much, Not Enough by Wim Laleman, Joan Claria, Schalk Van der Merwe, Richard Moreau, Jonel Trebicka

“…Dysbalanced immune function is central to its pathogenesis and outcome with an initial excessive systemic inflammatory response that drives organ failure and mortality. …”
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Colitis in spondyloarthritis by Muhammed Hafis, Vikas Agarwal

“…Several putative gut bacteria are implicated in the pathogenesis of SpA. IBD must be suspected in all patients of SpA presenting with abdominal pain, diarrhea, unexplained weight loss, anemia, or other malabsorption features. …”
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Glioblastoma Multiforme Stem Cells by Irena Dimov, Deasanka Tasic-Dimov, Irena Conic, Vladisav Stefanovic

“…The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapies primarily targeting GBM stem cells (GBMSCs). …”
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Polymicrobial Bacteremia Involving Comamonas testosteroni by Jose Orsini, Eric Tam, Naomi Hauser, Salil Rajayer

“…In spite of its uncommon human pathogenesis, there are few reports on the aggressive manner of it as an opportunistic pathogen, mostly related to testosteroni spp. …”
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Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney by Sergio Veloso Brant Pinheiro, Ana Cristina Simões e Silva

“…In this paper, we will discuss our current understanding of the ACE2/Ang-(1-7)/Mas axis of the RAS in renal physiology and in the pathogenesis of primary hypertension and chronic kidney disease.…”
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Acquired Abdominal Intercostal Hernia: A Case Report and Literature Review by Salim Abunnaja, Kevin Chysna, Inam Shaikh, Giuseppe Tripodi

“…This review discusses pathogenesis, clinical presentation, complications, and appropriate treatment strategies of AAIH.…”
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Moroccan natural products for multitarget-based treatment of Alzheimer's disease: A computational study. by Fatima Zahra Guerguer, Amal Bouribab, El Mehdi Karim, Meriem Khedraoui, Fatiha Amegrissi, Yasir S Raouf, Abdelouahid Samadi, Samir Chtita

“…Acetylcholinesterase, Butyrylcholinesterase, Monoamine Oxidase B, Beta-Secretase, and Glycogen Synthase Kinase Beta play central roles in its pathogenesis. Current medications primarily inhibit AChE but fail to halt or reverse disease progression due to the multifactorial nature of Alzheimer's. …”
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Cancer in myositis by Albert Selva-O'Callaghan, Maria Terrones-Peinador, Joana Rita Marques-Soares, Albert Gil-Vila

“…Several considerations regarding the pathogenesis of this association and strategies to detect occult malignancy in these patients are discussed here, with special emphasis on the role of autoantibodies as markers of this condition. …”
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The Interplay between the Bone and the Immune System by Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti

“…Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. …”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. As the pathogenesis of OA is unknown, there are almost no effective treatments available to prevent the onset or progression of the disease. …”
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The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease by Kemal Ugur Tufekci, Sermin Genc, Kursad Genc

“…Although the exact cause of the dopaminergic neurodegeneration remains elusive, recent postmortem and experimental studies have revealed an essential role for neuroinflammation that is initiated and driven by activated microglial and infiltrated peripheral immune cells and their neurotoxic products (such as proinflammatory cytokines, reactive oxygen species, and nitric oxide) in the pathogenesis of PD. A bacterial endotoxin-based experimental model of PD has been established, representing a purely inflammation-driven animal model for the induction of nigrostriatal dopaminergic neurodegeneration. …”
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