Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumatic and Nonrheumatic Aortic Stenosis by Lars Wallby, Thora Steffensen, Lena Jonasson, Mats Broqvist

“…The similarities regarding the localisation of calcification indicate that the valve anomaly/morphology can influence the pathogenesis of aortic stenosis. Finally, our findings highlight the question of a postinflammatory valvular disease of other causes than rheumatic fever.…”
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Deciphering the Role of Adrenergic Receptors in Alzheimer’s Disease: Paving the Way for Innovative Therapies by Androulla N. Miliotou, Andria Kotsoni, Lefteris C. Zacharia

“…The role of adrenergic receptors in the pathogenesis of Alzheimer’s disease and other tauopathies is poorly understood or investigated. …”
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Correction of Thrombocytopenia with Thrombopoietin Receptor Agonists in Patients with Liver Cirrhosis Before Elective Surgery or Invasive Procedures by T. A. Deeva, M. V. Maevskaya, V. T. Ivashkin

“…Aim: to review the pathogenesis of thrombocytopenia and possible ways of its correction in patients with liver cirrhosis before elective surgical interventions or invasive procedures to optimize clinical practice.Key points. …”
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Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…A third herpesvirus, human herpesvirus-8 (HHV-8), is crucial for the pathogenesis of Kaposi’s sarcoma, a common AIDS-related tumor of eyelid and conjunctiva. …”
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Helicobacter pylori Infection, Chronic Inflammation, and Genomic Transformations in Gastric MALT Lymphoma by Magdalena Witkowska, Piotr Smolewski

“…This paper is a review of the current knowledge on etiology, pathogenesis, treatment, and follow-up of gastric MALT lymphoma.…”
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Concomitant Nephrotic Syndrome and Cryoglobulinemia in a Case of Malignant Mesothelioma by Kei Nagai, Hiroaki Tachi, Kohei Inoue, Atsushi Ueda

“…Unfortunately, our rare case lacks a basis in renal pathology or evidence of links between the pathogenesis of malignant mesothelioma, cryoglobulinemia, and nephrotic syndrome. …”
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Novel heterozygous ASH1L nonsense variant involved in mild intellectual disability by Baoqiong Liao, Baoqiong Liao, Wuming Xie, Shuwen He

“…Our findings contribute to understanding the neurodevelopmental pathogenesis of mild ID in patients with the ASH1L nonsense variant mutation.…”
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The Role of Th17 Cells and IL-17 in Th2 Immune Responses of Allergic Conjunctivitis by Xiang-Tian Meng, Yun-Yue Shi, Hong Zhang, Hong-Yan Zhou

“…It has been found that new subpopulations of T-helper cells, Th17 cells that produce interleukin-17 (IL-17), play an important role in the Th2-mediated pathogenesis of conjunctivitis. Studies have shown that Th17 cells are involved in a variety of immune inflammation, including psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. …”
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Minimal Change Disease as a Secondary and Reversible Event of a Renal Transplant Case with Systemic Lupus Erythematosus by Elena Gkrouzman, Kyriakos A. Kirou, Surya V. Seshan, James M. Chevalier

“…Secondary causes of minimal change disease (MCD) account for a minority of cases compared to its primary or idiopathic form and provide ground for consideration of common mechanisms of pathogenesis. In this paper we report a case of a 27-year-old Latina woman, a renal transplant recipient with systemic lupus erythematosus (SLE), who developed nephrotic range proteinuria 6 months after transplantation. …”
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Changes of plasma cytokines content in Graves’ orbitopathy patients, could be potential markers by Ying Fu, Yuanyuan Zhang, Yaxin An, Bin Cao, Dong Zhao

“…Conclusions: ECM1, ENO1, and GPX3 were associated with the presence of the GO group and may be good biomarkers that play an important role in the pathogenesis of GO.…”
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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis. These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity. …”
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CD154: An Immunoinflammatory Mediator in Systemic Lupus Erythematosus and Rheumatoid Arthritis by Nada Alaaeddine, Ghada S. Hassan, Daniel Yacoub, Walid Mourad

“…This paper presents an overview of the interaction of CD154 with its various receptors and outlines its role in the pathogenesis of systemic lupus erythematosus and rheumatoid arthritis. …”
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IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis by Muhammad Babar Khawar, Muddasir Hassan Abbasi, Nadeem Sheikh

“…It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). …”
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Key Cell Types and Biomarkers in Heart Failure Identified through Analysis of Single-Cell and Bulk RNA Sequencing Data by Ying Kong, Ning Yang, Zhiqing Luo, Ruiting Huang, Quhuan Li

“…Although the role of inflammation in HF pathogenesis is well-known, the specific cell types and regulatory molecules involved remain poorly understood. …”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis. Drugs targeting these proteins are currently under consideration as antifibrotic treatments. …”
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The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Joshua A. David, William J. Rifkin, Piul S. Rabbani, Daniel J. Ceradini

“…Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. …”
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Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult by Yu-Jin Lee, D. Scott Smith, Vivek A. Rao, Robert D. Siegel, Jon Kosek, Carol A. Glaser, Alexander C. Flint

“…This case of fatal ANE in an adult is consistent with the hypothesis generated from pediatric cases that the host immune response, and not direct viral invasion of the CNS, is responsible for pathogenesis of ANE.…”
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Shifting the paradigm of type 1 diabetes: a narrative review of disease-modifying therapies by Alexander J. O’Donovan, Seth Gorelik, Seth Gorelik, Laura M. Nally

“…T1D is an autoimmune condition involving destruction of pancreatic beta cells leading to insulin deficiency, hyperglycemia, and long-term insulin dependence. The pathogenesis of T1D is classified into stages, with the first signal being the detection of autoantibodies without any glycemic changes. …”
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Role of T Regulatory Cells and Myeloid-Derived Suppressor Cells in COVID-19 by Alhasan Alsalman, Mohammad A. Al-Mterin, Eyad Elkord

“…Immunosuppressive cells including T regulatory cells (Tregs) and myeloid-derived suppressor cells (MDSCs) are key players in immunological tolerance and immunoregulation; however, they contribute to the pathogenesis of different diseases including infections. …”
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Graph Convolutional Network with Neural Collaborative Filtering for Predicting miRNA-Disease Association by Jihwan Ha

“…Therefore, much effort has been devoted to discovering the pivotal roles of miRNAs in disease incidence to understand the underlying pathogenesis of human diseases. However, identifying miRNA–disease associations using biological experiments is inefficient in terms of cost and time. …”
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