A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…Human ABC transporters are closely linked to the pathogenesis of diseases such as cancer, metabolic diseases, and Alzheimer’s disease. …”
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Serum Concentration of Interleukin-6 Is Increased Both in Active and Remission Stages of Pemphigus Vulgaris by Joanna Narbutt, Jolanta Lukamowicz, Jarosław Bogaczewicz, Anna Sysa-Jedrzejowska, Jolanta Dorota Torzecka, Aleksandra Lesiak

“…As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-α, IL-1, and IL-6 in PV patients in clinical remission. …”
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Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer by J. Kabzinski, A. Walczak, I. Majsterek

“…The oxidative damages are well-recognized factors in the pathogenesis of colorectal cancer (CRC). Increased levels of reactive oxygen species (ROS) can lead to oxidative DNA damage, which, if unrepaired, can be an underlying cause of cancerogenic transformation. …”
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Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease by Yajing Huang, Jingwei Chi, Fanxiang Wei, Yue Zhou, Yihai Cao, Yangang Wang

“…At present, there are more and more studies on the pathogenesis of DKD; mitochondrial dysfunction plays an important role in DKD. …”
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Autoimmunity related to anti-Nax and anti-ZSCAN1 autoantibodies in adipsic hypernatremia by Akari Nakamura-Utsunomiya

“…In this review, by summarizing a series of studies on Nax and ZSCAN1, which are expressed in the hypothalamus, pituitary gland, and SFO, I would like to describe the current findings of the autoimmune pathogenesis of adipsic hypernatremia.…”
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Strongyloidiasis: The Cause of Multiple Gastrointestinal Ulcers in an Immunocompetent Individual by Shail Sheth, Fady Asslo, Rabih Hallit, Raymund Sison, Muhammad Afridi, Robert Spira, Joseph DePasquale, Jihad Slim, Jack Boghossian

“…We suggest that the elevated eosinophil count played a central role in the pathogenesis.…”
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Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Stimulation Test in Studies of Depression, Alcoholism, and Suicidal Behavior by Leo Sher

“…Considerable evidence suggests that HPA dysregulation is involved in the pathogenesis of depressive disorders, alcoholism, and suicidal behavior. …”
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Study habits among Nigerian secondary school students with brain fag syndrome by Olufemi Morakinyo, Bolanle Adeyemi Ola

“…However, the contributions of study habits to the pathogenesis of this study-related illness deserve more attention than has been given. …”
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The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I by Maaike Dirckx, Marco W. J. Schreurs, Marissa de Mos, Dirk L. Stronks, Frank J. P. M. Huygen

“…Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.…”
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Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations by Nicholas New, Janaki Mohandas, George T. John, Sharad Ratanjee, Helen Healy, Leo Francis, Dwarakanathan Ranganathan

“…Clinical presentation, diagnosis, pathogenesis and treatment of calcific uremic arteriolopathy in these patients are no different from other patients manifesting with this condition.…”
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Burkitt’s Lymphoma of the Gastrohepatic Omentum: A Malignant Presentation of Pseudoachalasia by Eric Omar Then, Andrew Ofosu, Prashanth Rawla, Tagore Sunkara, Sriharsha Dadana, Andrea Culliford, Vinaya Gaduputi

“…Pseudoachalasia, in contrast, is a rare entity that causes identical symptoms, but has a divergent underlying pathogenesis. The symptomology in these cases oftentimes occurs secondary to extrinsic compression of the esophagus, mostly attributable to malignancy. …”
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A Pathological Analysis of Canaliculitis Concretions: More Than Just Actinomyces by Balaji Perumal, John Andrew Carlson, Dale Robert Meyer

“…Nonfilamentous bacteria may contribute to the pathogenesis of canaliculitis. In addition, the success of bacterial culture can be variable; therefore, pathological analysis can assist in determining the etiology.…”
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Pseudotyped Viruses: A Useful Platform for Pre-Clinical Studies Conducted in a BSL-2 Laboratory Setting by Sofiia N. Rizatdinova, Alina E. Ershova, Irina V. Astrakhantseva

“…During the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pseudotyped virus-based assays played a pivotal role in advancing our understanding of virus–cell interactions and the role of its proteins in disease pathogenesis. Such tools facilitated the search for potential therapeutic agents and accelerated epidemiological studies on post-infection and post-vaccination humoral immunity. …”
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Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy by Rui-Qi Wang, Zhi-Min Deng, Gan-Tao Chen, Fang-Fang Dai, Liang-Bin Xia

“…Additional clinical prospective and experimental studies are required to explore its precise pathogenesis. Through this review, we aim to provide strategies for improvement and treatment approaches for RSA related to obesity. …”
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The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives by Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang

“…Recent findings underscore the involvement of TRIM proteins in IVDD pathogenesis, where they regulate stress responses, maintain cellular homeostasis, and influence the functional integrity of nucleus pulposus (NP) and annulus fibrosus (AF) cells. …”
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Magnesium and Vascular Changes in Hypertension by Ana Rosa Cunha, Bianca Umbelino, Margarida L. Correia, Mario Fritsch Neves

“…Many factors have been implicated in the pathogenesis of hypertension, including changes in intracellular concentrations of calcium, sodium, potassium, and magnesium. …”
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Whole exome sequencing identifies genomic alterations in proximal and distal colorectal cancer by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Sheau Sean Khor, Sazuita Saidin, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Zuraini Abd. Razak, Isa Mohamed Rose, Ismail Sagap, Luqman Mazlan, Nadiah Abu, Rahman Jamal

“…However, further study in a larger series of samples coupled with functional studies will be required to confirm the identified variants and determine their roles in the pathogenesis of proximal and distal CRCs. …”
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Recent Pathophysiological Aspects of Peyronie’s Disease: Role of Free Radicals, Rationale, and Therapeutic Implications for Antioxidant Treatment—Literature Review by Gianni Paulis, Gennaro Romano, Luca Paulis, Davide Barletta

“…In recent years, numerous studies demonstrated the role played by oxidative stress in PD pathogenesis, and other studies have described successful use of antioxidants in PD treatment. …”
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Influence of Mast Cells in Drug-Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Swee Keong Yeap, Noorjahan Banu Alitheen

“…The purpose of this paper is to access the roles played by MCs in gingival overgrowth to hypothesize a relationship between these highly specialized cells in the pathogenesis of DIGO.…”
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REALIZATION OF THE PHENOTYPIC EFFECT OF CHROMOSOMAL ABERRATIONS IN HUMANS by K. N. Grinberg, V. I. Kukharenko

“…It is conceivable that chromosomal aberrations strengthen the evolutionarily conditioned variability towards the delay of maturation of cellular and tissue structures, which is the key link in the pathogenesis associated with chromosomal imbalance.…”
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