Anti-PD-1 exacerbates bleomycin-induced lung injury in mice via Caspase-3/GSDME-mediated pyroptosis by Fei Wang, Haiyi Deng, Maolin Zhou, Yilin Yang, Jiankui Zhou, Yansheng Wang, Xiaohong Xie, Xinqing Lin, Ming Liu, Gengyun Sun, Chengzhi Zhou

“…However, the lack of mouse animal models of ICI-related lung injury (ICI-LI) has limited the in-depth exploration of its pathogenesis. In clinical practice, underlying lung diseases increase the risk of lung injury. …”
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Intricating connections: the role of ferroptosis in systemic lupus erythematosus by Guowang Zhao, Xinghai Li, Ying Zhang, Ying Zhang, Xingzi Wang, Li Deng, Juan Xu, Shumei Jin, Zan Zuo, Zan Zuo, Linting Xun, Linting Xun, Mei Luo, Mei Luo, Fan Yang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Ping Fu

“…Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected. Therefore, this review elucidates the potential intricate relationship between SLE and ferroptosis to provide a reliable theoretical basis for further research on ferroptosis in the pathogenesis of SLE.…”
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Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database by Jing Tang, Jing Tang, Long Yang, Guan-Ying Yang, Yan-Hong Li, You-Sen Zhu, Hui Li, Xiao-Ming Gao, Xiao-Ming Gao, Xiao-Ming Gao

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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…These findings highlight the role of GluN2C-containing NMDARs in glutamatergic signaling and their potential contribution to AD pathogenesis.…”
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Mechanistic insights into HPV-positivity in non-smokers and HPV-negativity in smokers with head and neck cancer by Markus Hoffmann, Markus Hoffmann, Susanne Hille, Susanne Hille, Susanne Hille, Asita Fazel, Martin Laudien, Martin Laudien, Susanne Wiegand, Susanne Wiegand, Martin Müller, Oliver J. Müller, Oliver J. Müller, Oliver J. Müller, Elgar Susanne Quabius, Elgar Susanne Quabius

“…IntroductionSeveral aspects of the involvement of HPV in the pathogenesis of HPV-associated diseases remain poorly understood including mechanistic aspects of infection and the question of why the majority of HPV-positive HNSCC-patients are non-smokers, whereas HPV-negatives are smokers. …”
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Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS by Ruihua Wang, Changlian Gan, Rui Mao, Yang Chen, Ru Yan, Geng Li, Tianqin Xiong, Jianwen Guo

“…Using an LPS-induced ALI complicating ICH model, we also characterized SAP-induced brain, lung and gut histopathology injuries; peripheral immune disorders and intense pulmonary inflammatory responses.ConclusionsThese two models may be highly useful for investigating the pathogenesis and screening and optimizing potential treatments for SAP. …”
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LncRNA PTS-1 Protects Against Osteoarthritis Through the miR-8085/E2F2 Axis by Ma C, Chen Q, Wei YF, Chen SW, Liu H, Xin F, Ren YX

“…Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) in OA pathogenesis. This study focuses on lncRNA PTS-1, a novel lncRNA, to explore its function and regulatory mechanisms in OA progression.Methods: The expression profile of lncRNAs was assessed using RNA sequencing and qRT-PCR. …”
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Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation by Masahiko Ito, Jie Liu, Masayoshi Fukasawa, Koji Tsutsumi, Yumi Kanegae, Mitsutoshi Setou, Michinori Kohara, Tetsuro Suzuki

“…Impact and implications:: The involvement of phospholipid metabolism pathways in the pathogenesis of hepatitis C virus (HCV)-related liver diseases remains unclear. …”
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DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics by Dipanjan Bhattacharjee, Smita Shenoy, Kurady Laxminarayana Bairy

“…Using this review, we have attempted to shed light on two of the most important mechanisms implicated in cancer, that is, DNA (deoxyribonucleic acid) methylation and histone modifications, and their place in cancer pathogenesis. Further, we have attempted to take stock of the new epigenetic drugs that have emerged onto the market as well as those in the pipeline that offer hope in mankind’s fight against cancer.…”
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Clinical and Pathological Roles of Ro/SSA Autoantibody System by Ryusuke Yoshimi, Atsuhisa Ueda, Keiko Ozato, Yoshiaki Ishigatsubo

“…In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.…”
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Muscle-Specific Tyrosine Kinase-Associated Myasthenia Gravis: A Neuromuscular Surprise by Hassam Ali, Rahul Pamarthy, Nayab Ahsan, null WashmaAwan, Shiza Sarfraz

“…Muscle-specific tyrosine kinase myasthenia gravis (MuSK-Ab MG) is a rare subtype of myasthenia gravis with distinct pathogenesis and unique clinical features. Diagnosis can be challenging due to its atypical presentation as compared to seropositive myasthenia gravis. …”
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Bacterial metabolism in the host and its association with virulence by Amrita Bhagwat, Tiyasa Haldar, Poonam Kanojiya, Sunil D. Saroj

“…The metabolic adaptation plays pivotal role in bacterial pathogenesis. The understanding of host-pathogen metabolic crosstalk needs to be prioritized to decipher host-pathogen interactions. …”
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New horizons in the treatment of psoriasis: Modulation of gut microbiome by Mojtaba Memariani, Hamed Memariani

“…First, we outline the current knowledge on the unique gut microbiota patterns implicated in the pathogenesis of psoriasis. Second, and of equal importance, we briefly discuss the reciprocal impact of psoriasis treatment and gut microbiome. …”
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Control of Cross Talk between Angiogenesis and Inflammation by Mesenchymal Stem Cells for the Treatment of Ocular Surface Diseases by Fei Li, Shao-zhen Zhao

“…In this review, we discussed how angiogenesis and inflammation are orchestrated in the pathogenesis of ocular surface disease. We overviewed and updated the knowledge of MSCs and then summarized the therapeutic potential of MSCs via control of angiogenesis, inflammation, and immune response in the treatment of ocular surface disease.…”
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Integrative prognostic modeling of ovarian cancer: incorporating genetic, clinical, and immunological markers by Aidi Lin, Feifei Xue, Chenxiang Pan, Lijiao Li

“…Abstract Ovarian cancer has a high mortality rate, primarily due to late diagnosis and complex pathogenesis. This study develops an integrative prognostic model combining genetic, clinical, and immunological data to predict outcomes in ovarian cancer patients. …”
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Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients by N. Almaani, A. H. Al-Tarawneh, H. Msallam

“…However, ketoacidosis has been implicated in the pathogenesis and indeed prurigo pigmentosa has been associated with ketoacidotic states such as diabetes mellitus, fasting, dieting, and anorexia nervosa. …”
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Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke by Yongdan Cun, Yaju Jin, Danli Wu, Li Zhou, Chengcai Zhang, Simei Zhang, Xicheng Yang, null Zuhong Wang, Pengyue Zhang

“…The endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke. …”
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Autoimmune encephalitis: case reports of anti-NMDAR and anti-CASPR2 encephalitides and literature review by J. Kazlauskaitė, N. Giedraitienė, R. Masaitienė, A. Klimašauskienė

“…Cumulative research on the AE pathogenesis has resulted in a paradigm shift in clinical decision-making for these patients. …”
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Familial Atypical Hemolytic Uremic Syndrome: A Review of Its Genetic and Clinical Aspects by Fengxiao Bu, Nicolo Borsa, Ardissino Gianluigi, Richard J. H. Smith

“…The study of familial aHUS has implicated genetic variation in multiple genes in the complement system in disease pathogenesis, helping to define the mechanism whereby complement dysregulation at the cell surface level leads to both sporadic and familial disease. …”
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A Rare Sequela of Acute Disseminated Encephalomyelitis by Vijay Kodadhala, Saravana Devulapalli, Mohankumar Kurukumbi, Annapurni Jayam-Trouth

“…Primary and secondary immune responses contribute to inflammation and subsequent demyelination, but the exact pathogenesis is still unknown. Diagnosis of acute disseminated encephalomyelitis is strongly suggested by temporal relationship between an infection or an immunization and the onset of neurological symptoms. …”
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