The Bidirectional Signal Communication of Microbiota-Gut-Brain Axis in Hypertension by Xiaoqi Wang, Zhenzhen Chen, Bin Geng, Jun Cai

“…We reviewed the roles of neuroinflammation and gut microbiota and their interactions in the pathogenesis of hypertension and described the ascending signaling mechanisms behind the microbiota-gut-brain axis in detail. …”
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Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson’s Disease by Kuan Fan, Pengzhi Hu, Chengyuan Song, Xiong Deng, Jie Wen, Yiming Liu, Hao Deng

“…Genetic factors are thought to play an important role in the pathogenesis of Parkinson’s disease (PD), particularly early-onset PD. …”
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Polycystic Ovary Syndrome May Be an Autoimmune Disorder by Hifsa Mobeen, Nadeem Afzal, Muhammad Kashif

“…Genetic and hormonal factors play crucial role in the pathogenesis of PCOS. Low level of progesterone in PCOS causes overstimulation of immune system that produces more estrogen which leads to various autoantibodies. …”
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Bowel diseases and constipation in practice of the obstetrician and gynecologist by I. V. Kuznetsova, Yu. B. Uspenskaya

“…To present up-to-date data on etiology, pathogenesis and treatment of constipation in women of various age groups and at combined gynecologic diseases.Summary. …”
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Koro Syndrome: Epidemiology, Psychiatric and Physical Risk Factors, Clinical Presentation, Diagnosis, and Treatment Options by Yukino N. Strong, David Y. Cao, Jessica Zhou, Maya A. Guenther, Danyon J. Anderson, Alan D. Kaye, Brian E. Blick, Prathima R. Anandi, Hirni Y. Patel, Ivan Urits

“…Additional investigation on the prevalence, pathogenesis, factors that correlate with treatment efficacy are needed to fully understand Koro syndrome.…”
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L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle by Roger F. Butterworth

“…Studies in experimental animals and in patients demonstrate that ammonia is directly implicated in the pathogenesis of sarcopenia in cirrhosis via mechanisms involving increased expression of myostatin and of autophagy markers such as LC3 lipidation and p62 leading to muscle dysmetabolism and sarcopenia. …”
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Synergistic effects of mutation and glycosylation on disease progression by Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh

“…We highlight the synergistic contributions of missense amino acids in the mutant proteins and alterations in their glycosylation states to their molecular pathogenesis.…”
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Functional Foods and Nutraceuticals in the Primary Prevention of Cardiovascular Diseases by Eman M. Alissa, Gordon A. Ferns

“…Dietary factors are important in the pathogenesis of CVD and may to a large degree determine CVD risk, but have been less extensively investigated. …”
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Purple Urine Bag Syndrome: An Alarming Hue? A Brief Review of the Literature by Fahad Khan, Muhammad A. Chaudhry, Noorulain Qureshi, Benjamin Cowley

“…We hereby present a concise review of this rare phenomenon with historic perspectives, epidemiology, emphasizing on current concepts of etiology, pathogenesis, relevant clinical associations, treatment modalities, prognosis, and future directions in PUBS. …”
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Metabolomic profiles as a new understanding of disease processes by O. Yu. Zolnikova, M. S. Reshetova, M. N. Ivanova, V. T. Ivashkin

“…Metabolomic profile changes in different types of diseases will help to improve understanding of the pathogenesis. New therapeutic approaches may be developed. …”
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Regulatory role of PPAR in colorectal cancer by Cong Wang, Tingcong Lv, Binghui Jin, Yang Li, Zhe Fan

“…Despite the increase in awareness of CRC and the continuous improvement of medical treatment nowadays, the challenge of CRC still needs to be conquered. By now, the pathogenesis of CRC is complex and not fully understood. …”
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Crosstalk between the Intestinal Virome and Other Components of the Microbiota, and Its Effect on Intestinal Mucosal Response and Diseases by Njinju Asaba Clinton, Sodiq Ayobami Hameed, Eugene Kusi Agyei, Joy Chinwendu Jacob, Victor Oyewale Oyebanji, Cyril Ekabe Jabea

“…Finally, we elucidate the potential contribution of this crosstalk in the pathogenesis of inflammatory bowel diseases and colon cancer.…”
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Cross-Talk between Apolipoprotein E and Cytokines by Hongliang Zhang, Li-Min Wu, Jiang Wu

“…Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. …”
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Urinothorax Caused by Xanthogranulomatous Pyelonephritis by Waiel Abusnina, Hazim Bukamur, Zeynep Koc, Fauzi Najar, Nancy Munn, Fuad Zeid

“…Xanthogranulomatous pyelonephritis is a rare form of chronic pyelonephritis that generally afflicts middle-aged women with a history of recurrent urinary tract infections. Its pathogenesis generally involves calculus obstructive uropathy and its histopathology is characterized by replacement of the renal parenchyma with lipid filled macrophages. …”
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Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation by Elzbieta Waszczykowska, Ewa Robak, Anna Wozniacka, Joanna Narbutt, Jolanta Dorota Torzecka, Anna Sysa-Jedrzejowska

“…These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.…”
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Irritable bowel syndrome concept from the gut microbiom point of view by Anna F. Sheptulina, Vladimir T. Ivashkin

“…These in turn exert direct impact on quantitative and qualitative spectrum of gastrointestinal microbiota which changes, as it was demonstrated in the recent original studies, is an integral part of IBS pathogenesis and is the cornerstone of symptom origin of this func­ tional disorder. …”
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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…Intracellular nucleic acid sensing TLRs play an important role in the pathogenesis of Systemic Lupus Erythematosus (SLE). In this review, we describe recent achievements in the development of oligonucleotide—(ODN)-based inhibitors of TLR9 and/or TLR7 signaling. …”
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Eales’ Disease: When the Rare Sounds Frequent by Beatriz Oliveira Lopes, Margarida Sena Brízido, Ana Isabel Reis, Margarida Maria Miranda, Susana Morais Pina

“…Eales’ disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to Mycobacterium tuberculosis protein infers that immunologic disturbance may be involved. …”
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Effects of macrophages in OSCC progression by Xiaodan Dong, Xiaodan Dong, Chunling Dong, Bo Li

“…Although more and more experimental evidence and clinical data indicate that macrophages are involved in the onset and progression of oral squamous cell carcinoma (OSCC), the exact pathogenesis of OSCC associated with macrophages has not been fully elucidated. …”
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Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…Identification of the immunological mechanisms of host genetic susceptibility and the genetic basis of spontaneous colitis should provide new insights into the pathogenesis of human inflammatory bowel disease.…”
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