Preclinical research models for endometrial cancer: development and selection of animal models by Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang, Li Yang

“…Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new treatments. …”
Get full text

Research progress of circRNAs in bone-related diseases by Xianming Hua, Lingfeng Yu, Hao Zhu, Yan Zhu, Gentao Fan, Guangxin Zhou, Guangxin Zhou, Guangxin Zhou

“…Studies have shown that circRNAs play an irreplaceable role in the pathogenesis, disease progression, diagnosis, and targeted therapy of motor system tumors (osteosarcoma), metabolic diseases (osteoporosis), and degenerative diseases (osteonecrosis of the femoral head, osteoarthritis, intervertebral disc degeneration). …”
Get full text

Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction by Xiaoting Luo, Rongrong Li, Liang-Jun Yan

“…In this paper, we review the roles of pyruvate, NADH, and complex I in insulin secretion and hypothesize that complex I plays a crucial role in the pathogenesis of β cell dysfunction in the diabetic pancreas. …”
Get full text

Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases by Saroj Lohani, Niranjan Tachamo, Salik Nazir, Anthony Donato

“…Next steps would be further research on the pathogenesis of agranulocytosis associated with topiramate and creation of registry for data synthesis.…”
Get full text

Mechanism of Acupuncture and Moxibustion on Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Narrative Review of Animal Studies by Xiaoling Wu, Kai Cheng, Chang Xu, Shaoming Liu, Qianhui Sun, Zhiwen Yang, Xingye Dai, Na Li

“…At present, the disease’s aetiology and pathogenesis are unclear, and there is also no effective treatment for it. …”
Get full text

Stomach cancer risk factors: the modern concept by V. M. Khomyakov, A. D. Yermoshina, S. S. Pirogov, A. B. Ryabov

“…Intestinal type SC and diffuse type SC have various pathogenesis and risk factors. Risk factor estimation provides effective prophylaxis of the disease, and also to reveal high risk groups for preventive and screening programs.…”
Get full text

Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment by Qiuyan Guo, Yingnan Tang, Shengmei Wang, Xinhua Xia

“…Reactive oxygen species (ROS) play a crucial role in the pathogenesis of cancer. Non-invasive therapies that promote intracellular ROS generation, including photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT), have emerged as novel approaches for cancer treatment. …”
Get full text

Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002 by Janet M. Wojcicki, David Rehkopf, Elissa Epel, Philip Rosenthal

“…Longitudinal studies are necessary to evaluate the role of telomere length as a potential predictor to assess pathogenesis of NALFD in Mexicans.…”
Get full text

Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis by Roberta Sanguineti, Alessandra Puddu, François Mach, Fabrizio Montecucco, Giorgio Luciano Viviani

“…In the last twenty years, advanced glycation end products (AGEs) have been shown to be critical mediators both in the pathogenesis and development of osteoporosis and other chronic degenerative diseases related to aging. …”
Get full text

Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases by Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin

“…In this review, we will summarize current understandings and lines of evidence on the molecular mechanisms through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions.…”
Get full text

Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression by Rosaria Alba Merendino, Giuseppe Di Pasquale, Filippo De Luca, Laura Di Pasquale, Edoardo Ferlazzo, Gabriella Martino, Maura Carmela Palumbo, Fortunato Morabito, Sebastiano Gangemi

“…In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.…”
Get full text

Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity by Martin Regensburger, Iryna Prots, Beate Winner

“…Alterations in stem cell proliferation, differentiation, and survival as well as neurite outgrowth and spine formation have been related to different aspects in PD pathogenesis. Therefore, neurogenesis in the adult brain provides an ideal model to study disease mechanisms and compounds. …”
Get full text

CXCL13 Promotes Proliferation of Mesangial Cells by Combination with CXCR5 in SLE by Zhanyun Da, Liuxia Li, Jin Zhu, Zhifeng Gu, Bo You, Ying Shan, Si Shi

“…The results of our study elaborated that high expression of CXCL13 could be involved in the pathogenesis of LN.…”
Get full text

Early-Onset Chronic Inflammatory Disease Associated with Maternal Microchimerism by Tomoaki Ishikawa, Yoshihiko Sakurai, Tomohiro Takeda, Hiroshi Suzuki

“…Although HLA typing revealed no noninherited maternal antigens in lymphocytes, female cells were demonstrated in the patient’s skin and lymph nodes, suggesting that maternal microchimerism might be involved in the pathogenesis of fever without source in infants.…”
Get full text

Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease by Cui Zhang, Weigang Shu, Guangxi Zhou, Jian Lin, Feifei Chu, Huili Wu, Zhanju Liu

“…Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. …”
Get full text

Infectious hematopoietic necrosis (review) by K. A. Balakhnina, V. P. Melnikov

“…The paper provides a brief description of the IHN causative agent, describes its epidemiology, pathogenesis, clinical signs, post-mortem lesions, diagnostic tests, infection control and prevention measures. …”
Get full text

Perbandingan Asupan Makan Dan Aktifitas Fisik Pada Remaja Berdasarkan Status Gizi by Susmiati, Nur Indrawaty Lipoeto, Zifrianthi Minanda Putri

“…Effective treatment and prevention of obesity is achievable if its pathogenesis is known comprehensively. The objective of this research is to study and compare dietary intake and physical activities among adolescents between obese and normal ones. …”
Get full text

Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis by Jun-Hua Li, Jie-Ping Yu, Hong-Gang Yu, Xi-Ming Xu, Liang-Liang Yu, Jin Liu, He-Sheng Luo

“…Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. …”
Get full text

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

“…Recent studies have indicated the possible involvement of GRK, primarily GRK2 and GRK5, dysfunction in the pathogenesis of AD. It seems that mild, soluble, β-amyloid accumulation can lead to a reduced membrane (functional) and an elevated cytosolic GRK2/5. …”
Get full text

Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications by Mehrdad Afarid, Ehsan Namvar, Fatemeh Sanie-Jahromi

“…Brain-derived neurotrophic factor and the vascular endothelial growth factor have pivotal roles in the pathogenesis of diabetic retinopathy. They have neuroprotective effects on the retina. …”
Get full text